Cerebral Blood Flow Monitoring via Superconductive Nanowire Single Photon Detection

2021 ◽  
Author(s):  
Nisan Ozana ◽  
Dibbyan Mazumder ◽  
Alexander I. Zavriyev ◽  
Megan Blackwell ◽  
Stefan A. Carp ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Single Photon ◽  
Single Photon Detection ◽  
Photon Detection ◽  
Flow Monitoring

scholarly journals Single-Photon Detection Module Based on Large-Area Silicon Photomultipliers for Time-Domain Diffuse Optics

Instruments ◽  
2021 ◽  
Vol 5 (2) ◽  
pp. 18
Author(s):  
Fabio Acerbi ◽  
Anurag Behera ◽  
Alberto Dalla Mora ◽  
Laura Di Sieno ◽  
Alberto Gola
Keyword(s):  
Time Resolution ◽  
Time Domain ◽  
Single Photon ◽  
Building Blocks ◽  
The Body ◽  
Single Photon Detection ◽  
Silicon Photomultipliers ◽  
Photon Detection ◽  
Instrument Response Function ◽  
Diffuse Optics

Silicon photomultipliers (SiPM) are pixelated single-photon detectors combining high sensitivity, good time resolution and high dynamic range. They are emerging in many fields, such as time-domain diffuse optics (TD-DO). This is a promising technique in neurology, oncology, and quality assessment of food, wood, and pharmaceuticals. SiPMs can have very large areas and can significantly increase the sensitivity of TD-DO in tissue investigation. However, such improvement is currently limited by the high detector noise and the worsening of SiPM single-photon time resolution due to the large parasitic capacitances. To overcome such limitation, in this paper, we present two single-photon detection modules, based on 6 × 6 mm2 and 10 × 10 mm2 SiPMs, housed in vacuum-sealed TO packages, cooled to −15 °C and −36 °C, respectively. They integrate front-end amplifiers and temperature controllers, being very useful instruments for TD-DO and other biological and physical applications. The signal extraction from the SiPM was improved. The noise is reduced by more than two orders of magnitude compared to the room temperature level. The full suitability of the proposed detectors for TD-DO measurements is outside the scope of this work, but preliminary tests were performed analyzing the shape and the stability of the Instrument Response Function. The proposed modules are thus fundamental building blocks to push the TD-DO towards deeper investigations inside the body.

Research progress of infrared single-photon detection with high gain (Invited)

2021 ◽  
Vol 50 (1) ◽  
pp. 20211016-20211016
Author(s):  
吴静远 Jingyuan Wu ◽  
刘肇国 Zhaoguo Liu ◽  
张彤 Tong Zhang
Keyword(s):  
Single Photon ◽  
High Gain ◽  
Research Progress ◽  
Single Photon Detection ◽  
Photon Detection

A junction for single-photon detection

Science ◽  
2021 ◽  
Vol 372 (6540) ◽  
pp. 356.3-356
Author(s):  
Ian S. Osborne
Keyword(s):  
Single Photon ◽  
Single Photon Detection ◽  
Photon Detection

scholarly journals Regional Cerebral Blood Flow during Rest and Skilled Hand Movements by Xenon-133 Inhalation and Emission Computerized Tomography

1981 ◽  
Vol 1 (4) ◽  
pp. 385-389 ◽  
Author(s):  
Martin Lauritzen ◽  
Leif Henriksen ◽  
Niels A. Lassen
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Single Photon ◽  
Photon Emission ◽  
Hand Movements ◽  
Regional Cerebral Blood ◽  
Symmetric Pattern ◽  
Xenon 133 ◽  
The Right

Regional cerebral blood flow (CBF) was studied in 16 normal adult volunteers during rest and in 10 the study was repeated during skilled hand movements. A fast-rotating (“dynamic”), single-photon emission computerized tomograph (ECT) with four detector heads was used. Xenon-133 was inhaled over a 1-min period at a concentration of 10 mCi/L. The arrival and washout of the radioisotope was recorded during four 1-min periods. Two slices, 2 cm thick, 7 and 12 cm above the orbitomeatal line were obtained in every study. CBF averaged 60 ml/100 g/min (SD ± 11) in the lower slice and 51 ml/100 g/min (SD ± 13) in the upper slice. A symmetric pattern comparing right to left sides was found in both slices. Finger tapping and writing with the right hand increased CBF in specific areas of the upper slice: in the contralateral hand area by 35 ± 15% ( p < 0.025), and in the supplementary motor area on both sides by 34 ± 15% ( p < 0.025).

scholarly journals Extreme Ultraviolet to Visible Dispersed Single Photon Detection for Highly Sensitive Sensing of Fundamental Processes in Diverse Samples

Materials ◽  
2018 ◽  
Vol 11 (6) ◽  
pp. 869 ◽  
Author(s):  
Andreas Hans ◽  
Philipp Schmidt ◽  
Christian Ozga ◽  
Gregor Hartmann ◽  
Xaver Holzapfel ◽  
...  
Keyword(s):  
Extreme Ultraviolet ◽  
Single Photon ◽  
Single Photon Detection ◽  
Photon Detection ◽  
Highly Sensitive

Continuous regional cerebral blood flow monitoring in acute craniocerebral trauma

Neurosurgery ◽  
1991 ◽  
pp. 467 ◽  
Author(s):  
C A Dickman ◽  
L P Carter ◽  
H Z Baldwin ◽  
T Harrington ◽  
D Tallman
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Craniocerebral Trauma ◽  
Regional Cerebral Blood ◽  
Flow Monitoring
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