scholarly journals High sensitivity optical coherence detector optimization

2001 ◽  
Author(s):  
R.C. Coutinho ◽  
D.R. Selviah ◽  
H.A. French ◽  
H.D. Griffiths
Keyword(s):  
High Sensitivity ◽  
Optical Coherence

Ex Vivo assessment of competent strut coverage after coronary stenting by optical coherence tomography

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
R Bhoite ◽  
H Jinnouchi ◽  
F Otsuka ◽  
Y Sato ◽  
A Sakamoto ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Predictive Value ◽  
Ex Vivo ◽  
High Sensitivity ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Neointimal Thickness ◽  
Stent Strut ◽  
Oct Imaging ◽  
Definition Of

Abstract Background In many studies, struts coverage is defined as >0 mm of tissue overlying the stent struts by optical coherence tomography (OCT). However, this definition has never been validated using histology as the “gold standard”. The present study sought to assess the appropriate cut-off value of neointimal thickness of stent strut coverage by OCT using histology. Methods OCT imaging was performed on 39 human coronary arteries with stents from 25 patients at autopsy. A total of 165 cross-sectional images from 46 stents were co-registered with histology. The optimal cut-off value of strut coverage by OCT was determined. Strut coverage by histology was defined as endothelial cells with at least underlying two layers of smooth muscle cells. Considering the resolution of OCT is 10–20 μm, 3 different cut-off values (i.e. at ≥20, ≥40, and ≥60 μm) were assessed. Results A total of 2235 struts were evaluated by histology. Eventually, 1216 struts which were well-matched struts were analyzed in this study. By histology, uncovered struts were observed in 160 struts and covered struts were observed in 1056 struts. The broadly used definition of OCT-coverage which does not consider neointimal thickness yielded a poor specificity of 37.5% and high sensitivity 100%. Of 3 cut-off values, the cut-off value of >40 μm was more accurate as compared to >20 and >60 mm [sensitivity (99.3%), specificity (91.0%), positive predictive value (98.6%), and negative predictive value (95.6%)] Conclusion The most accurate cut-off value was ≥40 μm neointimal thickness by OCT in order to identify stent strut coverage validated by histology. Funding Acknowledgement Type of funding source: None

High sensitivity measurements of the scattering dispersion of phantoms using spectral domain optical coherence tomography

2006 ◽  
Author(s):  
Shellee D. Dyer ◽  
Tasshi Dennis ◽  
Paul A. Williams ◽  
Lara K. Street ◽  
Shelley M. Etzel ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
High Sensitivity ◽  
Spectral Domain ◽  
Optical Coherence

High-sensitivity determination of birefringence in turbid media with enhanced polarization-sensitive optical coherence tomography

2005 ◽  
Vol 22 (3) ◽  
pp. 552 ◽  
Author(s):  
Nate J. Kemp ◽  
Jesung Park ◽  
Haitham N. Zaatari ◽  
H. Grady Rylander ◽  
Thomas E. Milner
Keyword(s):  
Optical Coherence Tomography ◽  
High Sensitivity ◽  
Turbid Media ◽  
Optical Coherence

scholarly journals Multimodal instrument for high-sensitivity autofluorescence and spectral optical coherence tomography of the human eye fundus

2013 ◽  
Vol 4 (11) ◽  
pp. 2683 ◽  
Author(s):  
Katarzyna Komar ◽  
Patrycjusz Stremplewski ◽  
Marta Motoczyńska ◽  
Maciej Szkulmowski ◽  
Maciej Wojtkowski
Keyword(s):  
Optical Coherence Tomography ◽  
High Sensitivity ◽  
Optical Coherence ◽  
Human Eye ◽  
Spectral Optical Coherence Tomography

scholarly journals High sensitivity phase mapping with parallel Fourier domain optical coherence tomography at 512 000 A-scan/s

2010 ◽  
Vol 18 (21) ◽  
pp. 21841 ◽  
Author(s):  
Branislav Grajciar ◽  
Yves Lehareinger ◽  
Adolf F. Fercher ◽  
Rainer A. Leitgeb
Keyword(s):  
Optical Coherence Tomography ◽  
High Sensitivity ◽  
Fourier Domain ◽  
Optical Coherence ◽  
Phase Mapping

scholarly journals Supercontinuum Parallel Line-Field Optical Coherence Tomography for High Sensitivity, Kilohertz Frame Rate Imaging

2017 ◽  
Author(s):  
Jessica Barrick ◽  
Ana Doblas ◽  
Michael Gardner ◽  
Patrick R. Sears ◽  
Lawrence E. Ostrowski ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
High Sensitivity ◽  
Parallel Line ◽  
Frame Rate ◽  
Optical Coherence ◽  
Line Field

scholarly journals Optical Coherence Tomography Angiography versus Dye Angiography in Age-Related Macular Degeneration: Sensitivity and Specificity Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Eleni Nikolopoulou ◽  
Massimo Lorusso ◽  
Luisa Micelli Ferrari ◽  
Maria Vittoria Cicinelli ◽  
Francesco Bandello ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Sensitivity And Specificity ◽  
Optical Coherence Tomography Angiography ◽  
High Sensitivity ◽  
Age Related Macular Degeneration ◽  
Type I ◽  
Optical Coherence ◽  
Type Ii ◽  
Age Related

Introduction. Optical coherence tomography angiography (OCTA) could be a valid tool to detect choroidal neovascularization (CNV) in neovascular age-related macular degeneration (nAMD), allowing the analysis of the type, the morphology, and the extension of CNV in most of the cases. Purpose. To determine the sensitivity and specificity of OCTA in detecting CNV secondary to nAMD, compared to fluorescein angiography (FA) and indocyanine green angiography (ICGA). Methods. Prospective observational study. Patients with suspected nAMD were recruited between May and December 2016. Patients underwent FA, ICGA, spectral domain OCT, and OCTA (AngioVue, Optovue, Inc.). Sensitivity and specificity of FA, with or without ICGA, were assessed and compared with OCTA. Results. Seventy eyes of 70 consecutive patients were included: 32 eyes (45.7%) with type I CNV, 8 eyes (11.4%) with type II CNV, 4 eyes (5.7%) with type III CNV, 6 eyes (8.6%) with mixed type I and type II CNV, and 20 eyes (28.6%) with no CNV. Sensitivity of OCTA was 88% and specificity was 90%. Concordance between FA/ICGA and OCTA was very good (0,91; range 0,81–1,00). Conclusions. OCTA showed high sensitivity and specificity for detection of CNV. Concordance between OCTA and gold-standard dye-based techniques was excellent. OCTA may represent a first-line noninvasive method for the diagnosis of nAMD.

scholarly journals Detection and characterisation of optic nerve and retinal changes in primary congenital glaucoma using hand-held optical coherence tomography

2019 ◽  
Vol 4 (1) ◽  
pp. e000194
Author(s):  
Anastasia V Pilat ◽  
Sonal Shah ◽  
Viral Sheth ◽  
Ravi Purohit ◽  
Frank A Proudlock ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Young Children ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
High Sensitivity ◽  
Congenital Glaucoma ◽  
Optical Coherence ◽  
External Limiting Membrane ◽  
Primary Congenital Glaucoma

ObjectiveTo investigate (1) the feasibility of scanning the optic nerve (ON) and central retina with hand-held optical coherence tomography (HH-OCT) without sedation or anaesthesia in primary congenital glaucoma (PCG), (2) the characteristics of ON changes in comparison with adult primary open-angle glaucoma (POAG) in comparison with matched controls, (3) the sensitivity and specificity of ON parameters for diagnosis, and (4) changes of foveal morphology.Methods and analysisHH-OCT (Envisu 2300; Leica Microsystems) was used to investigate ON and foveal morphology of 20 children with PCG (mean age 4.64±2.79) and 10 adult patients with POAG (mean age 66.8±6.94), and compared with age-matched, gender-matched and ethnicity-matched healthy controls without sedation or anaesthesia.ResultsHH-OCT yielded useful data in 20 out of 24 young children with PCG. Patients with PCG had significantly deeper cup changes than patients with POAG (vs respective age-matched controls, p=0.014). ON changes in PCG are characterised by significant increase in cup depth (165%), increased cup diameter (159%) and reduction in rim area (36.4%) as compared with controls with high sensitivity (81.5, 74.1% and 88.9%, respectively) and specificity (85.0, 80.0% and 75.0%, respectively). Patients with PCG have a significantly smaller width of the macula pit (p<0.001) with non-detectable external limiting membrane.ConclusionHH-OCT has the potential to be a useful tool in glaucoma management for young children. We have demonstrated the use of HH-OCT in confirming a diagnosis of glaucoma within the studied cohort and found changes in disc morphology which characterise differently in PCG from POAG.

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