scholarly journals High-speed imaging of human retina in vivo with swept-source optical coherence tomography

2006 ◽  
Vol 14 (26) ◽  
pp. 12902 ◽  
Author(s):  
H. Lim ◽  
M. Mujat ◽  
C. Kerbage ◽  
E. C. W. Lee ◽  
Y. Chen ◽  
...  
Sensors ◽  
2021 ◽  
Vol 21 (19) ◽  
pp. 6463
Author(s):  
Sevin Samadi ◽  
Javad Dargahi ◽  
Sivakumar Narayanswamy

We report the design of a high-efficiency spectral-domain spectrometer with cylindrical optics for line scanning optical coherence tomography (OCT). The spectral nonlinearity in k space (wavenumber) lowers the depth-dependent signal sensitivity of the spectrometers. For linearizing, in this design, grating and prism have been introduced. For line scanning, a cylindrical mirror is utilized in the scanning part. Line scanning improves the speed of imaging compared to fly-spot scanning. Line scanning OCT requires a spectrometer that utilizes cylindrical optics. In this work, an optical design of a linear wavenumber spectrometer with cylindrical optics is introduced. While there are many works using grating and prism to linearize the K space spectrometer design, there is no work on linearizing the k-space spectrometer with cylindrical optics for line scanning that provides high sensitivity and high-speed imaging without the need for resampling. The design of the spectrometer was achieved through MATLAB and ZEMAX simulations. The spectrometer design is optimized for the broadband light source with a center wavelength of 830 ± 100 nm (8.607 μm−1− 6.756 μm−1 in k-space). The variation in the output angle with respect to the wavenumber can be mentioned as a nonlinearity error. From our design results, it is observed that the nonlinearity error reduced from 147.0115 to 0.0149 Δθ*μm within the wavenumber range considered. The use of the proposed reflective optics for focusing reduces the chromatic aberration and increases image quality (measured by the Strehl ratio (SR)). The complete system will provide clinicians a powerful tool for real-time diagnosis, treatment, and guidance in surgery with high image quality for in-vivo applications.


2005 ◽  
Vol 13 (26) ◽  
pp. 10652 ◽  
Author(s):  
Yoshiaki Yasuno ◽  
Violeta Dimitrova Madjarova ◽  
Shuichi Makita ◽  
Masahiro Akiba ◽  
Atsushi Morosawa ◽  
...  

2009 ◽  
Vol 02 (01) ◽  
pp. 117-122 ◽  
Author(s):  
TONG WU ◽  
ZHIHUA DING ◽  
MINGHUI CHEN ◽  
LEI XU ◽  
GUOHUA SHI ◽  
...  

A swept-source optical coherence tomography (SSOCT) system based on a high-speed scanning laser source at center wavelength of 1320 nm and scanning rate of 20 kHz is developed. The axial resolution is enhanced to 8.3 μm by reshaping the spectrum in frequency domain using a window function and a wave number calibration method based on a Mach-Zender Interferometer (MZI) integrated in the SSOCT system. The imaging speed and depth range are 0.04 s per frame and 3.9 mm, respectively. The peak sensitivity of the SSOCT system is calibrated to be 112 dB. With the developed SSOCT system, optical coherence tomography (OCT) images of human finger tissue are obtained which enable us to view the sweat duct (SD), stratum corneum (SC) and epidermis (ED), demonstrating the feasibility of the SSOCT system for in vivo biomedical imaging.


2020 ◽  
Vol 10 (14) ◽  
pp. 4936
Author(s):  
Pingping Jia ◽  
Hong Zhao ◽  
Yuwei Qin

A high-speed, high-resolution swept-source optical coherence tomography (SS-OCT) is presented for focusing lens imaging and a k-domain uniform algorithm is adopted to find the wave number phase equalization. The radius of curvature of the laser focusing lens was obtained using a curve-fitting algorithm. The experimental results demonstrate that the measuring accuracy of the proposed SS-OCT system is higher than the laser confocal microscope. The SS-OCT system has great potential for surface topography measurement and defect inspection of the focusing lens.


2017 ◽  
Vol 51 (4) ◽  
pp. 410-418 ◽  
Author(s):  
Rupert S. Austin ◽  
Maisalamah Haji Taha ◽  
Frederic Festy ◽  
Richard Cook ◽  
Manoharan Andiappan ◽  
...  

Swept-source optical coherence tomography (SS-OCT) shows potential for the in vivo quantitative evaluation of micro-structural enamel surface phenomena occurring during early erosive demineralization. This randomized controlled single-blind cross-over clinical study aimed to evaluate the use of SS-OCT for detecting optical changes in the enamel of 30 healthy volunteers subjected to orange juice rinsing (erosive challenge) in comparison to mineral water rinsing (control), according to wiped and non-wiped enamel surface states. Participants were randomly allocated to 60 min of orange juice rinsing (pH 3.8) followed by 60 min of water rinsing (pH 6.7) and vice versa, with a 2-week wash-out period. In addition, the labial surfaces of the right or left maxillary incisors were wiped prior to SS-OCT imaging. An automated ImageJ algorithm was designed to analyse the back-scattered OCT signal intensity (D) after orange juice rinsing compared to after water rinsing. D was quantified as the OCT signal scattering from the 33 µm sub-surface enamel, normalised by the total OCT signal intensity entering the enamel. The back-scattered OCT signal intensity increased by 3.1% (95% CI 1.1-5.1%) in the wiped incisors and by 3.5% (95% CI 1.5-5.5%) in the unwiped incisors (p < 0.0001). Wiping reduced the back-scattered OCT signal intensity by 1.7% (95% CI -3.2 to -0.3%; p = 0.02) in comparison to the unwiped enamel surfaces for both rinsing solutions (p = 0.2). SS-OCT detected OCT signal changes in the superficial sub-surface enamel of maxillary central incisor teeth of healthy volunteers after orange juice rinsing.


2015 ◽  
Author(s):  
Hee Yoon Lee ◽  
Patrick D. Raphael ◽  
Audrey K. Ellerbee ◽  
Brian E. Applegate ◽  
John S. Oghalai

2005 ◽  
Author(s):  
Erich Goetzinger ◽  
Michael Pircher ◽  
Rainer A. Leitgeb ◽  
Adolf F. Fercher ◽  
Christoph K. Hitzenberger

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