scholarly journals Scan-less machine-learning-enabled incoherent microscopy for minimally-invasive deep brain imaging

2021 ◽  
Author(s):  
Ruipeng Guo ◽  
Soren Nelson ◽  
Mathew REGIER ◽  
M. Davis ◽  
Erik Jorgensen ◽  
...  
2018 ◽  
Vol 7 (1) ◽  
Author(s):  
Sebastian A. Vasquez-Lopez ◽  
Raphaël Turcotte ◽  
Vadim Koren ◽  
Martin Plöschner ◽  
Zahid Padamsey ◽  
...  

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Alexandre Boutet ◽  
Radhika Madhavan ◽  
Gavin J. B. Elias ◽  
Suresh E. Joel ◽  
Robert Gramer ◽  
...  

AbstractCommonly used for Parkinson’s disease (PD), deep brain stimulation (DBS) produces marked clinical benefits when optimized. However, assessing the large number of possible stimulation settings (i.e., programming) requires numerous clinic visits. Here, we examine whether functional magnetic resonance imaging (fMRI) can be used to predict optimal stimulation settings for individual patients. We analyze 3 T fMRI data prospectively acquired as part of an observational trial in 67 PD patients using optimal and non-optimal stimulation settings. Clinically optimal stimulation produces a characteristic fMRI brain response pattern marked by preferential engagement of the motor circuit. Then, we build a machine learning model predicting optimal vs. non-optimal settings using the fMRI patterns of 39 PD patients with a priori clinically optimized DBS (88% accuracy). The model predicts optimal stimulation settings in unseen datasets: a priori clinically optimized and stimulation-naïve PD patients. We propose that fMRI brain responses to DBS stimulation in PD patients could represent an objective biomarker of clinical response. Upon further validation with additional studies, these findings may open the door to functional imaging-assisted DBS programming.


2020 ◽  
Vol 7 (7) ◽  
pp. 2103
Author(s):  
Yoshihisa Matsunaga ◽  
Ryoichi Nakamura

Background: Abdominal cavity irrigation is a more minimally invasive surgery than that using a gas. Minimally invasive surgery improves the quality of life of patients; however, it demands higher skills from the doctors. Therefore, the study aimed to reduce the burden by assisting and automating the hemostatic procedure a highly frequent procedure by taking advantage of the clearness of the endoscopic images and continuous bleeding point observations in the liquid. We aimed to construct a method for detecting organs, bleeding sites, and hemostasis regions.Methods: We developed a method to perform real-time detection based on machine learning using laparoscopic videos. Our training dataset was prepared from three experiments in pigs. Linear support vector machine was applied using new color feature descriptors. In the verification of the accuracy of the classifier, we performed five-part cross-validation. Classification processing time was measured to verify the real-time property. Furthermore, we visualized the time series class change of the surgical field during the hemostatic procedure.Results: The accuracy of our classifier was 98.3% and the processing cost to perform real-time was enough. Furthermore, it was conceivable to quantitatively indicate the completion of the hemostatic procedure based on the changes in the bleeding region by ablation and the hemostasis regions by tissue coagulation.Conclusions: The organs, bleeding sites, and hemostasis regions classification was useful for assisting and automating the hemostatic procedure in the liquid. Our method can be adapted to more hemostatic procedures. 


2018 ◽  
Vol 2 (suppl_1) ◽  
pp. 849-849
Author(s):  
J Kernbach ◽  
L Rogenmoser ◽  
G Schlaug ◽  
C Gaser

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