Introduction:
Polyvinyl alcohol (PVA), a polymer, is in demand due to its usage in different
applications such as pharmaceutical, biomedical and textile, paper, food industries.
Methods:
A new sensitive reversed phased high-pressure liquid chromatography (RP-HPLC) method
with refractive index detector (RID) was developed for determination of PVA in an ophthalmic solution
containing dexpanthenol and PVA as active substances and it was validated according to The International
Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH)
guideline.
Results:
Chromatographic separation was achieved on a Chiral-AGP (150 mm × 4.0 mm, 5 μm) column
kept at 30°C with an isocratic flow at a flow rate of 1.0 ml/min. The detector temperature was 30°C, the
retention time of PVA was around 1.0 min and the total run time was 5 minutes.
Conclusion:
The proposed method showed linearity, accuracy, precision, specificity, robustness, solution
stability, and system suitability results within the acceptance criteria.
High performance graphene oxide-based humidity sensor integrated on a photonic crystal cavity
