scholarly journals Super-resolution photoacoustic imaging via flow-induced absorption fluctuations

Optica ◽  
2017 ◽  
Vol 4 (11) ◽  
pp. 1397 ◽  
Author(s):  
Thomas Chaigne ◽  
Bastien Arnal ◽  
Sergey Vilov ◽  
Emmanuel Bossy ◽  
Ori Katz
Keyword(s):  
Photoacoustic Imaging ◽  
Super Resolution ◽  
Induced Absorption

scholarly journals Ultrasound and Photoacoustic Imaging of Laser-Activated Phase-Change Perfluorocarbon Nanodroplets

Photonics ◽  
2021 ◽  
Vol 8 (10) ◽  
pp. 405
Author(s):  
Heechul Yoon
Keyword(s):  
Phase Change ◽  
Photoacoustic Imaging ◽  
Super Resolution ◽  
Optical Pulses ◽  
Future Directions ◽  
Therapeutic Drugs ◽  
Contrast Enhanced ◽  
Resolution Imaging ◽  
Optical Activation ◽  
Micrometer Size

Laser-activated perfluorocarbon nanodroplets (PFCnDs) are emerging phase-change contrast agents that showed promising potential in ultrasound and photoacoustic (US/PA) imaging. Unlike monophase gaseous microbubbles, PFCnDs shift their state from liquid to gas via optical activation and can provide high US/PA contrast on demand. Depending on the choice of perfluorocarbon core, the vaporization and condensation dynamics of the PFCnDs are controllable. Therefore, these configurable properties of activation and deactivation of PFCnDs are employed to enable various imaging approaches, including contrast-enhanced imaging and super-resolution imaging. In addition, synchronous application of both acoustic and optical pulses showed a promising outcome vaporizing PFCnDs with lower activation thresholds. Furthermore, due to their sub-micrometer size, PFCnDs can be used for molecular imaging of extravascular tissue. PFCnDs can also be an effective therapeutic tool. As PFCnDs can carry therapeutic drugs or other particles, they can be used for drug delivery, as well as photothermal and photodynamic therapies. Blood barrier opening for neurological applications was recently demonstrated with optically-triggered PFCnDs. This paper specifically focuses on the activation and deactivation properties of laser-activated PFCnDs and associated US/PA imaging approaches, and briefly discusses their theranostic potential and future directions.

Super-resolution approaches in photoacoustic imaging

2019 ◽  
Vol 145 (3) ◽  
pp. 1779-1779 ◽  
Author(s):  
Bastien Arnal ◽  
Sergey Vilov ◽  
Guillaume Godefroy ◽  
Emmanuel Bossy
Keyword(s):  
Photoacoustic Imaging ◽  
Super Resolution

scholarly journals Autoencoder based blind source separation for photoacoustic resolution enhancement

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Matan Benyamin ◽  
Hadar Genish ◽  
Ran Califa ◽  
Lauren Wolbromsky ◽  
Michal Ganani ◽  
...  
Keyword(s):  
Photoacoustic Imaging ◽  
Resolution Enhancement ◽  
Super Resolution ◽  
Optical Excitation ◽  
Biological Tissues ◽  
General Idea ◽  
Acoustic Response ◽  
Depth Imaging ◽  
Resolution Imaging ◽  
Novel Concept

AbstractPhotoacoustics is a promising technique for in-depth imaging of biological tissues. However, the lateral resolution of photoacoustic imaging is limited by size of the optical excitation spot, and therefore by light diffraction and scattering. Several super-resolution approaches, among which methods based on localization of labels and particles, have been suggested, presenting promising but limited solutions. This work demonstrates a novel concept for extended-resolution imaging based on separation and localization of multiple sub-pixel absorbers, each characterized by a distinct acoustic response. Sparse autoencoder algorithm is used to blindly decompose the acoustic signal into its various sources and resolve sub-pixel features. This method can be used independently or as a combination with other super-resolution techniques to gain further resolution enhancement and may also be extended to other imaging schemes. In this paper, the general idea is presented in details and experimentally demonstrated.

scholarly journals Super-resolution photoacoustic imaging through a scattering wall

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Donald B. Conkey ◽  
Antonio M. Caravaca-Aguirre ◽  
Jake D. Dove ◽  
Hengyi Ju ◽  
Todd W. Murray ◽  
...  
Keyword(s):  
Photoacoustic Imaging ◽  
Super Resolution

scholarly journals A tumor microenvironment–induced absorption red-shifted polymer nanoparticle for simultaneously activated photoacoustic imaging and photothermal therapy

2021 ◽  
Vol 7 (12) ◽  
pp. eabe3588
Author(s):  
Shulong Wang ◽  
Liangliang Zhang ◽  
Jingjin Zhao ◽  
Min He ◽  
Yong Huang ◽  
...  
Keyword(s):  
Absorption Spectrum ◽  
Tumor Microenvironment ◽  
Redox Reaction ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Tumor Imaging ◽  
Photoacoustic Imaging ◽  
Diagnosis And Treatment ◽  
Induced Absorption

Tumor microenvironment–responsive therapy has enormous application potential in the diagnosis and treatment of cancer. The glutathione (GSH) level has been shown to be significantly increased in tumor tissues. Thus, GSH can be used as an effective endogenous molecule for diagnosis and tumor microenvironment–activated therapy. In this study, we prepared a tumor microenvironment–induced, absorption spectrum red-shifted, iron-copper co-doped polyaniline nanoparticle (Fe-Cu@PANI). The Cu(II) in this nanoparticle can undergo a redox reaction with GSH in tumors. The redox reaction induces a red shift in the absorption spectrum of the Fe-Cu@PANI nanoparticles from the visible to the near-infrared region accompanying with the etching of this nanoparticle, which simultaneously activates tumor photoacoustic imaging and photothermal therapy, thereby improving the accuracy of in vivo tumor imaging and the efficiency of photothermal therapy. The nanoparticle prepared in this study has broad application prospects in the diagnosis and treatment of cancer.

Super-resolution photoacoustic imaging of single gold nanoparticles

2016 ◽  
Author(s):  
Seunghyun Lee ◽  
Owoong Kwon ◽  
Mansik Jeon ◽  
Jaejung Song ◽  
Minguk Jo ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Photoacoustic Imaging ◽  
Super Resolution

scholarly journals Advances in super-resolution photoacoustic imaging

2018 ◽  
Vol 8 (8) ◽  
pp. 724-732 ◽  
Author(s):  
Junhui Shi ◽  
Yuqi Tang ◽  
Junjie Yao
Keyword(s):  
Photoacoustic Imaging ◽  
Super Resolution
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