Exploring Time-Dependent Structural Changes during the Cold Crystallization Process of Isotactic Polystyrene by Infrared Spectroscopy and Multivariate Curve Resolution

2006 ◽  
Vol 60 (2) ◽  
pp. 155-161 ◽  
Author(s):  
Boyan Li ◽  
Jianming Zhang ◽  
Yun Hu ◽  
Yizeng Liang ◽  
Yukihiro Ozaki
Keyword(s):  
Infrared Spectroscopy ◽  
Structural Changes ◽  
Crystallization Process ◽  
Cold Crystallization ◽  
Time Dependent ◽  
Multivariate Curve Resolution ◽  
Isotactic Polystyrene ◽  
Curve Resolution

scholarly journals Cocrystal Formation through Solid-State Reaction between Ibuprofen and Nicotinamide Revealed Using THz and IR Spectroscopy with Multivariate Analysis

Crystals ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 760
Author(s):  
Sae Ishihara ◽  
Yusuke Hattori ◽  
Makoto Otsuka ◽  
Tetsuo Sasaki
Keyword(s):  
Ir Spectroscopy ◽  
Solid Phase ◽  
Time Dependent ◽  
Multivariate Curve Resolution ◽  
Thz Spectroscopy ◽  
Water Molecules ◽  
Active Pharmaceutical Ingredients ◽  
Curve Resolution ◽  
Pharmaceutical Ingredients ◽  
Solid Phase Reactions

Cocrystallisation can enhance the solubility and bioavailability of active pharmaceutical ingredients (APIs); this method may be applied to improve the availability of materials that were previously considered unsuitable. Terahertz (THz) spectroscopy provides clear, substance-specific fingerprint spectra; the transparency of the THz wave allows us to probe inside a sample to identify medicinal materials. In this study, THz and infrared (IR) spectroscopy were used to characterise cocrystallisation in solid-phase reactions between ibuprofen and nicotinamide. Multivariate curve resolution with alternating least squares (MCR-ALS) was applied to both time-dependent THz and IR spectra to identify the intermolecular interactions between these cocrystallising species. The analytical results revealed cocrystal formation through a two-step reaction, in which the steps were dominated by thermal energy and water vapour, respectively. We infer that the presence of water molecules significantly lowered the activation energy of cocrystal formation.

Mid-infrared spectroscopy and multivariate curve resolution for analyzing human adipose tissue triacylglycerols

2010 ◽  
Vol 112 (12) ◽  
pp. 1308-1314 ◽  
Author(s):  
Jesper Lundbom ◽  
Marjukka Kolehmainen ◽  
Leena Pulkkinen ◽  
Pasi Soininen ◽  
Mika Tiainen ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Infrared Spectroscopy ◽  
Human Adipose Tissue ◽  
Multivariate Curve Resolution ◽  
Mid Infrared ◽  
Mid Infrared Spectroscopy ◽  
Curve Resolution
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