scholarly journals WNT16 Influences Bone Mineral Density, Cortical Bone Thickness, Bone Strength, and Osteoporotic Fracture Risk

PLoS Genetics ◽  
2012 ◽  
Vol 8 (7) ◽  
pp. e1002745 ◽  
Author(s):  
Hou-Feng Zheng ◽  
Jon H. Tobias ◽  
Emma Duncan ◽  
David M. Evans ◽  
Joel Eriksson ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Fracture Risk ◽  
Cortical Bone ◽  
Bone Strength ◽  
Bone Mineral ◽  
Osteoporotic Fracture ◽  
Bone Thickness ◽  
Mineral Density ◽  
Cortical Bone Thickness

scholarly journals Distal radial cortical bone thickness correlates with bone mineral density and can predict osteoporosis: a cohort study

Injury ◽  
2020 ◽  
Vol 51 (11) ◽  
pp. 2617-2621
Author(s):  
ChunXiao Ye ◽  
YingBin Guo ◽  
YouHui Zheng ◽  
ZhenBin Wu ◽  
KaiYu Chen ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Cohort Study ◽  
Cortical Bone ◽  
Bone Mineral ◽  
Bone Thickness ◽  
Mineral Density ◽  
Cortical Bone Thickness

Cortical Bone Thickness of the Distal Part of the Tibia Predicts Bone Mineral Density

2016 ◽  
Vol 98 (9) ◽  
pp. 751-760 ◽  
Author(s):  
Jason Patterson ◽  
Chamnanni Rungprai ◽  
Taylor Den Hartog ◽  
Yubo Gao ◽  
Annunziato Amendola ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Cortical Bone ◽  
Bone Mineral ◽  
Distal Part ◽  
Bone Thickness ◽  
Mineral Density ◽  
Cortical Bone Thickness

Cortical bone thickness predicts the quantitative bone mineral density of the proximal humerus

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Florian Schmidutz ◽  
Shuang G. Yan ◽  
Christoph Schopf ◽  
Christoph Ihle ◽  
Marc-Daniel Ahrend ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Cortical Bone ◽  
Bone Mineral ◽  
Proximal Humerus ◽  
Bone Thickness ◽  
Mineral Density ◽  
Cortical Bone Thickness

Cortical Bone Thickness and Bone Mineral Density

2013 ◽  
Vol 16 (1) ◽  
pp. 127-128
Author(s):  
Souhail G. Shamiyeh ◽  
Elias G. Shamiyeh ◽  
Vaishali Chhaya
Keyword(s):  
Bone Mineral Density ◽  
Cortical Bone ◽  
Bone Mineral ◽  
Bone Thickness ◽  
Mineral Density ◽  
Cortical Bone Thickness

scholarly journals Systems genetics analyses in Diversity Outbred mice inform human bone mineral density GWAS and identify Qsox1 as a novel determinant of bone strength

2020 ◽  
Author(s):  
Basel Al-Barghouthi ◽  
Larry D. Mesner ◽  
Gina M. Calabrese ◽  
Daniel Brooks ◽  
Steve M. Tommasini ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Cortical Bone ◽  
Bone Strength ◽  
Bone Mineral ◽  
Association Studies ◽  
Systems Genetics ◽  
Genome Wide Association Studies ◽  
Mineral Density ◽  
Diversity Outbred ◽  
Wide Range

ABSTRACTGenome-wide association studies (GWASs) for osteoporotic traits have identified over 1000 associations; however, their impact has been limited by the difficulties of causal gene identification and a strict focus on bone mineral density (BMD). Here, we used Diversity Outbred (DO) mice to directly address these limitations by performing the first systems genetics analysis of over 50 complex skeletal phenotypes. We applied a network approach to cortical bone RNA-seq data to discover 46 genes likely to be causal for human BMD GWAS associations, including the novel genes SERTAD4 and GLT8D2. We also performed GWAS in the DO for a wide-range of bone traits and identified Qsox1 as a novel gene influencing cortical bone accrual and bone strength. Our results provide a new perspective on the genetics of osteoporosis and highlight the ability of the mouse to inform human genetics.

scholarly journals Bone quality: what is it and how is it measured?

2006 ◽  
Vol 50 (4) ◽  
pp. 579-585 ◽  
Author(s):  
Juliet Compston
Keyword(s):  
Bone Mineral Density ◽  
Bone Turnover ◽  
Fracture Risk ◽  
Bone Strength ◽  
Bone Quality ◽  
Bone Mineral ◽  
Bone Matrix ◽  
Mineral Density ◽  
New Techniques ◽  
Composition And Structure

Bone quality describes aspects of bone composition and structure that contribute to bone strength independently of bone mineral density. These include bone turnover, microarchitecture, mineralisation, microdamage and the composition of bone matrix and mineral. New techniques to assess these components of bone quality are being developed and should produce important insights into determinants of fracture risk in untreated and treated disease.

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