Sexual transmission of Zika virus and other flaviviruses: A living systematic review

Arthropod-borne viruses (arboviruses) are primarily maintained in nature in transmission cycles between hematophagous arthropods and vertebrate hosts, but an increasing number of arboviruses have been isolated from or indirectly detected in the urogenital tract and sexual secretions of their vertebrate hosts, indicating that further investigation on the possibility of sexual transmission of these viruses is warranted. The most widely recognized sexually-transmitted arbovirus is Zika virus but other arboviruses, including Crimean-Congo hemorrhagic fever virus and dengue virus, might also be transmitted, albeit occasionally, by this route. This review summarizes our current understanding on the ability of arboviruses to be sexually transmitted. We discuss the sexual transmission of arboviruses between humans and between vertebrate animals, but not arthropod vectors. Every taxonomic group known to contain arboviruses (Asfarviridae, Bunyavirales, Flaviviridae, Orthomyxoviridae, Reoviridae, Rhabdoviridae and Togaviridae) is covered.

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Update: Interim Guidance for Prevention of Sexual Transmission of Zika Virus — United States, 2016

MMWR Morbidity and Mortality Weekly Report ◽

10.15585/mmwr.mm6512e3er ◽

2016 ◽

Vol 65 (12) ◽

Cited By ~ 1

Author(s):

Alexandra M. Oster ◽

Kate Russell ◽

Jo Ellen Stryker ◽

Allison Friedman ◽

Rachel E. Kachur ◽

...

Keyword(s):

United States ◽

Zika Virus ◽

Sexual Transmission ◽

Prevention Of Sexual Transmission

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Zika virus history, spread, and potential for sexual transmission

10.1603/ice.2016.111618 ◽

2016 ◽

Author(s):

Brian D. Foy

Keyword(s):

Zika Virus ◽

Sexual Transmission

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Transmission of Zika virus through breast milk and other breastfeeding-related bodily-fluids: a systematic review

Bulletin of the World Health Organization ◽

10.2471/blt.16.176677 ◽

2016 ◽

Cited By ~ 2

Author(s):

Susannah Colt ◽

Maria N Garcia-Casal ◽

Juan Pablo Peña-Rosas ◽

Julia L. Finkelstein ◽

Pura Rayco-Solon ◽

...

Keyword(s):

Systematic Review ◽

Breast Milk ◽

Zika Virus ◽

Bodily Fluids

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Molecular mechanisms of Zika virus teratogenesis from animal studies: a systematic review protocol

Systematic Reviews ◽

10.1186/s13643-021-01713-6 ◽

2021 ◽

Vol 10 (1) ◽

Author(s):

Gabriela Elis Wachholz ◽

Julia do Amaral Gomes ◽

Juliano André Boquett ◽

Fernanda Sales Luiz Vianna ◽

Lavínia Schuler-Faccini ◽

...

Keyword(s):

Systematic Review ◽

Animal Models ◽

Zika Virus ◽

Methodological Quality ◽

Molecular Mechanisms ◽

Grey Literature ◽

Standard Form ◽

Teratogenic Effect ◽

Control Group

Abstract Background Due to the diversity of studies in animal models reporting that molecular mechanisms are involved in the teratogenic effect of the Zika virus (ZIKV), the objective of the present study is to evaluate the methodological quality of these studies, as well as to demonstrate which genes and which molecular pathways are affected by ZIKV in different animal models. Methods This search will be performed in four databases: PubMed/MEDLINE, EMBASE, Web of Science, and Scopus, as well as in the grey literature. The studies selection process will be reported through the PRISMA Statement diagram model. All studies describing the molecular mechanisms possibly involved in the development of malformations caused by embryonic/fetal ZIKV exposure in animal models with an appropriate control group and methodology will be included (including, for instance, randomized and non-randomized studies). All animals used as experimental models for ZIKV teratogenesis may be included as long as exposure to the virus occurred during the embryonic/fetal period. From the selected studies, data will be extracted using a previously prepared standard form. Bias risk evaluation will be conducted following the SYRCLE’s Risk of Bias tool. All data obtained will be tabulated and organized by outcomes (morphological and molecular). Discussion With the proposed systematic review, we expect to present results about the methodological quality of the published studies with animal models that investigated the molecular mechanisms involved in the teratogenic effect of ZIKV, as well as to show the studies with greater reliability. Systematic review registration PROSPERO CRD42019157316

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Sexual Transmission of Zika Virus and Persistence in Semen, New Zealand, 2016

Emerging Infectious Diseases ◽

10.3201/eid2210.160951 ◽

2016 ◽

Vol 22 (10) ◽

pp. 1855-1857 ◽

Cited By ~ 56

Author(s):

Jay Harrower ◽

Tomasz Kiedrzynski ◽

Simon Baker ◽

Arlo Upton ◽

Fahimeh Rahnama ◽

...

Keyword(s):

New Zealand ◽

Zika Virus ◽

Sexual Transmission

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NS2B‐NS3 protease inhibitors as promising compounds in the development of antivirals against Zika virus: A systematic review

Journal of Medical Virology ◽

10.1002/jmv.27386 ◽

2021 ◽

Author(s):

Damiana Antônia de Fátima Nunes ◽

Felipe Rocha da Silva Santos ◽

Sara Thamires Dias da Fonseca ◽

William Gustavo de Lima ◽

Waleska Stephanie da Cruz Nizer ◽

...

Keyword(s):

Systematic Review ◽

Protease Inhibitors ◽

Zika Virus ◽

Ns3 Protease Inhibitors ◽

Ns3 Protease

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Knowledge of the Sexual Transmission of Zika Virus and Preventive Practices Against Zika Virus Among U.S. Travelers

Journal of Community Health ◽

10.1007/s10900-018-0594-x ◽

2018 ◽

Vol 44 (2) ◽

pp. 377-386 ◽

Cited By ~ 5

Author(s):

Erik J. Nelson ◽

Maya C. Luetke ◽

Conner McKinney ◽

Oghenekaro Omodior

Keyword(s):

Zika Virus ◽

Sexual Transmission ◽

Preventive Practices

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Knowledge, Attitudes, and Practices about Zika among a University Community Located in an Endemic Zone in Mexico

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph15112548 ◽

2018 ◽

Vol 15 (11) ◽

pp. 2548 ◽

Cited By ~ 2

Author(s):

Vianey Argüelles-Nava ◽

María Alvarez-Bañuelos ◽

Daniel Córdoba-Suárez ◽

Clara Sampieri ◽

María Ortiz-León ◽

...

Keyword(s):

Zika Virus ◽

Online Survey ◽

Sexual Transmission ◽

Univariate Analysis ◽

Attitudes And Practices ◽

Medium Level ◽

Study Population ◽

Level Of Knowledge ◽

The University ◽

Knowledge Attitudes And Practices

To assess the knowledge, attitudes, and practices about the Zika virus in both students and workers at the University of Veracruz, an online survey was conducted. The participants were divided into two groups: one according to sex, the other according to whether they were workers or students. Their answers were classified into knowledge, attitudes, and practices and they were rated as low, medium, and high. The results showed that knowledge about Zika prevailing among the university population is considered as medium in 79.4% of the study population. Most respondents know that the mosquito spreads the Zika virus (98.8%) and the clinical characteristics, while sexual transmission by the virus is little known (36.85%). Both the univariate analysis (OR (CI5) 0.227 (0.070–0.735), p = 0.013] and multivariate analysis (OR (CI95) 0.234 (0.071–778), p = 0.018] showed that belonging to the health sciences area is related to having a greater knowledge about Zika. Despite the existing knowledge, a low level of prevention practices prevails in the whole community (55%). A medium level of knowledge about Zika prevailed, while proper implementation of preventive measures for Zika is low, despite the fact that the state of Veracruz—the place where the University is located—is an endemic area.

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