Transmission of Zika virus through breast milk and other breastfeeding-related bodily-fluids: a systematic review

2016 ◽  
Author(s):  
Susannah Colt ◽  
Maria N Garcia-Casal ◽  
Juan Pablo Peña-Rosas ◽  
Julia L. Finkelstein ◽  
Pura Rayco-Solon ◽  
...  
Keyword(s):  
Systematic Review ◽  
Breast Milk ◽  
Zika Virus ◽  
Bodily Fluids

scholarly journals Transmission of Zika virus through breast milk and other breastfeeding-related bodily-fluids: A systematic review

2017 ◽  
Vol 11 (4) ◽  
pp. e0005528 ◽  
Author(s):  
Susannah Colt ◽  
Maria N. Garcia-Casal ◽  
Juan Pablo Peña-Rosas ◽  
Julia L. Finkelstein ◽  
Pura Rayco-Solon ◽  
...  
Keyword(s):  
Systematic Review ◽  
Breast Milk ◽  
Zika Virus ◽  
Bodily Fluids

scholarly journals Breast milk transmission of flaviviruses in the context of Zika virus: A systematic review

2018 ◽  
Vol 32 (4) ◽  
pp. 358-368 ◽  
Author(s):  
Taylor Z. Mann ◽  
Lisa B. Haddad ◽  
Tonya R. Williams ◽  
Susan L. Hills ◽  
Jennifer S. Read ◽  
...  
Keyword(s):  
Systematic Review ◽  
Breast Milk ◽  
Zika Virus ◽  
Breast Milk Transmission

scholarly journals Molecular mechanisms of Zika virus teratogenesis from animal studies: a systematic review protocol

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Gabriela Elis Wachholz ◽  
Julia do Amaral Gomes ◽  
Juliano André Boquett ◽  
Fernanda Sales Luiz Vianna ◽  
Lavínia Schuler-Faccini ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Zika Virus ◽  
Methodological Quality ◽  
Molecular Mechanisms ◽  
Grey Literature ◽  
Standard Form ◽  
Teratogenic Effect ◽  
Control Group

Abstract Background Due to the diversity of studies in animal models reporting that molecular mechanisms are involved in the teratogenic effect of the Zika virus (ZIKV), the objective of the present study is to evaluate the methodological quality of these studies, as well as to demonstrate which genes and which molecular pathways are affected by ZIKV in different animal models. Methods This search will be performed in four databases: PubMed/MEDLINE, EMBASE, Web of Science, and Scopus, as well as in the grey literature. The studies selection process will be reported through the PRISMA Statement diagram model. All studies describing the molecular mechanisms possibly involved in the development of malformations caused by embryonic/fetal ZIKV exposure in animal models with an appropriate control group and methodology will be included (including, for instance, randomized and non-randomized studies). All animals used as experimental models for ZIKV teratogenesis may be included as long as exposure to the virus occurred during the embryonic/fetal period. From the selected studies, data will be extracted using a previously prepared standard form. Bias risk evaluation will be conducted following the SYRCLE’s Risk of Bias tool. All data obtained will be tabulated and organized by outcomes (morphological and molecular). Discussion With the proposed systematic review, we expect to present results about the methodological quality of the published studies with animal models that investigated the molecular mechanisms involved in the teratogenic effect of ZIKV, as well as to show the studies with greater reliability. Systematic review registration PROSPERO CRD42019157316

scholarly journals Update on the Transmission of Zika Virus Through Breast Milk and Breastfeeding: A Systematic Review of the Evidence

Viruses ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 123
Author(s):  
Elizabeth Centeno-Tablante ◽  
Melisa Medina-Rivera ◽  
Julia L. Finkelstein ◽  
Heather S. Herman ◽  
Pura Rayco-Solon ◽  
...  
Keyword(s):  
Breast Milk ◽  
Zika Virus ◽  
Mother To Child Transmission ◽  
Inclusion Criteria ◽  
Rt Pcr ◽  
Child Transmission ◽  
Zikv Infection ◽  
Milk Samples ◽  
Clinical Complications ◽  
Mother To Child

We systematically searched regional and international databases and screened 1658 non-duplicate records describing women with suspected or confirmed ZIKV infection, intending to breastfeed or give breast milk to an infant to examine the potential of mother-to-child transmission of Zika virus (ZIKV) through breast milk or breastfeeding-related practices. Fourteen studies met our inclusion criteria and inform this analysis. These studies reported on 97 mother–children pairs who provided breast milk for ZIKV assessment. Seventeen breast milk samples from different women were found positive for ZIKV via RT-PCR, and ZIKV replication was found in cell cultures from five out of seven breast milk samples from different women. Only three out of six infants who had ZIKV infection were breastfed, no evidence of clinical complications was found to be associated with ZIKV RNA in breast milk. This review updates our previous report by including 12 new articles, in which we found no evidence of ZIKV mother-to-child transmission through breast milk intake or breastfeeding. As the certainty of the present evidence is low, additional studies are still warranted to determine if ZIKV can be transmitted through breastfeeding.

scholarly journals Effect of Maternal Body Mass Index on Hormones in Breast Milk: A Systematic Review

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e115043 ◽  
Author(s):  
Nicholas J. Andreas ◽  
Matthew J. Hyde ◽  
Chris Gale ◽  
James R. C. Parkinson ◽  
Suzan Jeffries ◽  
...  
Keyword(s):  
Systematic Review ◽  
Body Mass Index ◽  
Breast Milk ◽  
Body Mass ◽  
Maternal Body Mass Index ◽  
Maternal Body

NS2B‐NS3 protease inhibitors as promising compounds in the development of antivirals against Zika virus: A systematic review

2021 ◽  
Author(s):  
Damiana Antônia de Fátima Nunes ◽  
Felipe Rocha da Silva Santos ◽  
Sara Thamires Dias da Fonseca ◽  
William Gustavo de Lima ◽  
Waleska Stephanie da Cruz Nizer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Protease Inhibitors ◽  
Zika Virus ◽  
Ns3 Protease Inhibitors ◽  
Ns3 Protease

scholarly journals Zika Virus Infection as a Cause of Congenital Brain Abnormalities and Guillain–Barré Syndrome: Systematic Review

PLoS Medicine ◽  
2017 ◽  
Vol 14 (1) ◽  
pp. e1002203 ◽  
Author(s):  
Fabienne Krauer ◽  
Maurane Riesen ◽  
Ludovic Reveiz ◽  
Olufemi T. Oladapo ◽  
Ruth Martínez-Vega ◽  
...  
Keyword(s):  
Systematic Review ◽  
Virus Infection ◽  
Zika Virus ◽  
Guillain Barre Syndrome ◽  
Brain Abnormalities ◽  
Zika Virus Infection ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

scholarly journals Association of breast milk fatty acids with allergic disease outcomes-A systematic review

Allergy ◽  
2017 ◽  
Vol 73 (2) ◽  
pp. 295-312 ◽  
Author(s):  
N. T. Waidyatillake ◽  
S. C. Dharmage ◽  
K. J. Allen ◽  
C. J. Lodge ◽  
J. A. Simpson ◽  
...  
Keyword(s):  
Systematic Review ◽  
Fatty Acids ◽  
Breast Milk ◽  
Allergic Disease ◽  
Milk Fatty Acids ◽  
Disease Outcomes

scholarly journals Times to Key Events in the Course of Zika Infection and their Implications for Surveillance: A Systematic Review and Pooled Analysis

2016 ◽  
Author(s):  
Justin Lessler ◽  
Cassandra T. Ott ◽  
Andrea C. Carcelen ◽  
Jacob M. Konikoff ◽  
Joe Williamson ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Supply ◽  
Zika Virus ◽  
Blood Donation ◽  
Case Reports ◽  
Fold Increase ◽  
Pooled Analysis ◽  
Control Measures ◽  
History Of ◽  
And Control

Background Evidence suggests that Zika virus has driven a 10-fold increase in babies born with microcephaly in Brazil, prompting the WHO to declare a Public Health Emergency of International Concern. However, little is known about the natural history of infection. These data are critical for implementation of surveillance and control measures such as protecting the blood supply. Methods We conducted a systematic review and pooled analysis to estimate the distribution of times from Zika infection to symptom onset, seroconversion, and viral clearance, and analyzed their implications for surveillance and blood supply safety. Results Based on 25 case reports, we estimate the median incubation period of Zika virus infection is 5.9 days (95% CI: 4.4-7.6), and that 95% of cases will develop symptoms by 11.1 days post-infection (95% CI: 7.6-18.0). On average seroconversion occurs 9.0 days (95% CI, 7.0-11.6) after infection, and virus is detectable in blood for 9.9 days (95% CI: 6.8-21.4). In 5% of cases detectable virus persists for over 18.9 days (95% CI: 12.6-79.5). The baseline (no screening) risk of a blood donation being infected with Zika increases by approximately 1 in 10,000 for every 1 per 100,000 person-days increase in Zika incidence. Symptom based screening reduces this by 7% (RR 0.93, 93% CI 0.86-0.99), and antibody screening by 29% (RR 0.71, 95% CI: 0.28-0.88). Conclusions Symptom or antibody-based surveillance can do little to reduce the risk of Zika contaminated blood donations. High incidence areas may consider PCR testing to identify lots safe for use in pregnant women.

scholarly journals Sleep in children with microcephaly due to Zika virus infection: a systematic review

2021 ◽  
Vol 55 ◽  
Author(s):  
Emanuele Mariano de Souza Santos ◽  
Monique Carla da Silva Reis ◽  
Antonio Lucas Ferreira Feitosa ◽  
Andréa Monteiro Correia Medeiros
Keyword(s):  
Systematic Review ◽  
Virus Infection ◽  
Zika Virus ◽  
Brain Activity ◽  
Common Finding ◽  
Infant Sleep ◽  
Quality Of Sleep ◽  
Sleep Questionnaire ◽  
Zika Virus Infection

ABSTRACT Objective: To review the literature on sleep changes and brain function in children with microcephaly due to Zika virus. Method: Systematic review conducted in the databases MEDLINE (PubMed), Scopus, Web of Science, CINAHL, EMBASE, LILACS, and SciELO and the grey databases Google Scholar and OpenGrey. Results: Ten Brazilian primary studies with observational research design were included. These were published between 2017 and 2020 with 516 children with microcephaly due to Zika virus infection aged 4 months to 4 years. Out of these, 4 investigated qualitative aspects of sleep using the questionnaires Brief Infant Sleep Questionnaire or Infant Sleep Questionnaire and 6 investigated changes in brain activities during sleep using the Electroencephalogram or Video-Electroencephalogram exams. The children’s quality of sleep was not compromised in most studies. Changes in brain activity during sleep were frequent, with epileptogenic activity being a common finding among the studies. Conclusion: The quality of sleep of children with microcephaly due to Zika virus has shown to be similar to that of children with typical development and the presented behavioral changes may be related to changes in electric brain activity.

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