Leprosy postexposure prophylaxis with single-dose rifampicin: Nepalese dermatologist’s dilemma

Abstract Varicella outbreaks continue to occur in schools. We assessed potential factors associated with the size and duration of 560 school-based outbreaks in Shanghai, China. Outbreaks occurring in primary and middle schools involved more cases and had longer durations, and conducting postexposure prophylaxis campaigns was an effective strategy for outbreak control.

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Development of Nevirapine Resistance in Infants Is Reduced by Use of Infant‐Only Single‐Dose Nevirapine plus Zidovudine Postexposure Prophylaxis for the Prevention of Mother‐to‐Child Transmission of HIV‐1

The Journal of Infectious Diseases ◽

10.1086/499967 ◽

2006 ◽

Vol 193 (4) ◽

pp. 479-481 ◽

Cited By ~ 32

Author(s):

Susan H. Eshleman ◽

Donald R. Hoover ◽

Sarah E. Hudelson ◽

Shu Chen ◽

Susan A. Fiscus ◽

...

Keyword(s):

Single Dose ◽

Mother To Child Transmission ◽

Postexposure Prophylaxis ◽

Child Transmission ◽

Single Dose Nevirapine ◽

Nevirapine Resistance ◽

Mother To Child ◽

Hiv 1

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Single Dose of Doxycycline for the Prevention of Tick-borne Relapsing Fever

Clinical Infectious Diseases ◽

10.1093/cid/ciaa034 ◽

2020 ◽

Vol 71 (7) ◽

pp. 1768-1771 ◽

Cited By ~ 1

Author(s):

Yoav Binenbaum ◽

Ronen Ben-Ami ◽

Gad Baneth ◽

Boaz Langford ◽

Yoav Negev ◽

...

Keyword(s):

Single Dose ◽

High Risk ◽

Observational Study ◽

Postexposure Prophylaxis ◽

Relapsing Fever

Abstract The current postexposure prophylaxis regimen for tick-borne relapsing fever (TBRF) consists of 5 days’ doxycycline. In this observational study of 77 spelunkers at high risk for TBRF, a single dose of 100 mg doxycycline taken up to 72 hours after exposure to ticks was 100% effective in preventing the disease.

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The Response of Testes Cells to Low Level, Single dose Helium Particle Irradiation

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100053929 ◽

1982 ◽

Vol 40 ◽

pp. 252-253

Author(s):

D.E. Philpott ◽

W. Sapp ◽

C. Williams ◽

J. Stevenson ◽

S. Black ◽

...

Keyword(s):

Stem Cell ◽

Single Dose ◽

B Cell ◽

Cell Survival ◽

Spermatogonial Stem Cell ◽

Low Doses ◽

Particle Irradiation ◽

Stem Cell Survival ◽

Irradiation Injury ◽

Radio Sensitivity

Spermatogonial stem-cell survival after irradiation injury has been studied in rodents by histological counts of surviving cells. Many studies, including previous work from our laboratory, show that the spermatogonial population demonstrates a heterogeneous response to irradiation. The spermatogonia increase in radio-sensitivity as differentiation proceeds through the sequence As - Apr - A1 - A2 - A3 - A4 - In - B. The stem (As) cell is the most resistant and the B cell is the most sensitive. The purpose of this work is to investigate the response of spermatogonial cell to low doses (less than 10 0 rads) of helium particle irradiation.

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Gastric Ulcers Produced by Cisplatin

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100099337 ◽

1981 ◽

Vol 39 ◽

pp. 582-583

Author(s):

S.K. Aggarwal ◽

J. San Antonio

Keyword(s):

Electron Microscopy ◽

Single Dose ◽

Side Effects ◽

Antitumor Agent ◽

Gastric Ulcers ◽

Enzyme Cytochemistry ◽

Intestinal Toxicity ◽

Ovarian Cancers ◽

Inner Surface

Cisplatin (cis-dichlorodiammineplatinum(II)) a potent antitumor agent is now available for the treatment of testicular and ovarian cancers. It is however, not free from its serious side effects including nephrotoxicity, gastro intestinal toxicity, myelosuppression, and ototoxicity. Here we now report that the drug produces peculiar bloating of the stomach in rats and induces acute ulceration.Wistar-derived rats weighing 200-250 g were administered cisplatin(9 mg/kg) ip as a single dose in 0.15 M NaCl. After 3 days the animals were sacrificed by decapitation. The stomachs were removed, the contents analyzed for pepsin and acidity. The inner surface was examined with a dissecting microscope after a moderate stretching for ulcers. Affected areas were fixed and processed for routine electron microscopy and enzyme cytochemistry.The drug treated animals kept on food and water consistently showed bloating and lesions (Fig. 1) with a frequency of 6-70 ulcers in the rumen section of the stomachs.

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