scholarly journals Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi

2021 ◽  
Vol 15 (10) ◽  
pp. e0009077
Author(s):  
Gregório Guilherme Almeida ◽  
Pedro Augusto Carvalho Costa ◽  
Maísa da Silva Araujo ◽  
Gabriela Ribeiro Gomes ◽  
Alex Fiorini Carvalho ◽  
...  
Keyword(s):  
Plasmodium Vivax ◽  
Potential Role ◽  
Brazilian Amazon ◽  
Asymptomatic Infection ◽  
Membrane Feeding ◽  
Plasmodium Vivax Malaria ◽  
Local Vector ◽  
Hematological And Biochemical Parameters ◽  
Asymptomatic Individuals ◽  
Membrane Feeding Assay

Individuals with asymptomatic infection due to Plasmodium vivax are posited to be important reservoirs of malaria transmission in endemic regions. Here we studied a cohort of P. vivax malaria patients in a suburban area in the Brazilian Amazon. Overall 1,120 individuals were screened for P. vivax infection and 108 (9.6%) had parasitemia detected by qPCR but not by microscopy. Asymptomatic individuals had higher levels of antibodies against P. vivax and similar hematological and biochemical parameters compared to uninfected controls. Blood from asymptomatic individuals with very low parasitemia transmitted P. vivax to the main local vector, Nyssorhynchus darlingi. Lower mosquito infectivity rates were observed when blood from asymptomatic individuals was used in the membrane feeding assay. While blood from symptomatic patients infected 43.4% (199/458) of the mosquitoes, blood from asymptomatic infected 2.5% (43/1,719). However, several asymptomatic individuals maintained parasitemia for several weeks indicating their potential role as an infectious reservoir. These results suggest that asymptomatic individuals are an important source of malaria parasites and Science and Technology for Vaccines granted by Conselho Nacional de may contribute to the transmission of P. vivax in low-endemicity areas of malaria.

scholarly journals Expression Levels of pvcrt-o and pvmdr-1 Are Associated with Chloroquine Resistance and Severe Plasmodium vivax Malaria in Patients of the Brazilian Amazon

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e105922 ◽  
Author(s):  
Gisely C. Melo ◽  
Wuelton M. Monteiro ◽  
André M. Siqueira ◽  
Siuhelem R. Silva ◽  
Belisa M. L. Magalhães ◽  
...  
Keyword(s):  
Plasmodium Vivax ◽  
Vivax Malaria ◽  
Brazilian Amazon ◽  
Chloroquine Resistance ◽  
Expression Levels ◽  
Plasmodium Vivax Malaria

scholarly journals Clinical Profile of Concurrent Dengue Fever and Plasmodium vivax Malaria in the Brazilian Amazon: Case Series of 11 Hospitalized Patients

2012 ◽  
Vol 87 (6) ◽  
pp. 1119-1124 ◽  
Author(s):  
Belisa M. L. Magalhães ◽  
André M. Siqueira ◽  
Quique Bassat ◽  
Marcus V. G. Lacerda ◽  
Gisely C. Melo ◽  
...  
Keyword(s):  
Plasmodium Vivax ◽  
Dengue Fever ◽  
Vivax Malaria ◽  
Case Series ◽  
Brazilian Amazon ◽  
Hospitalized Patients ◽  
Clinical Profile ◽  
Plasmodium Vivax Malaria

scholarly journals Optimization of a Membrane Feeding Assay for Plasmodium vivax Infection in Anopheles albimanus

2016 ◽  
Vol 10 (6) ◽  
pp. e0004807 ◽  
Author(s):  
Andrés F. Vallejo ◽  
Kelly Rubiano ◽  
Andres Amado ◽  
Amy R. Krystosik ◽  
Sócrates Herrera ◽  
...  
Keyword(s):  
Plasmodium Vivax ◽  
Vivax Infection ◽  
Anopheles Albimanus ◽  
Feeding Assay ◽  
Membrane Feeding ◽  
Membrane Feeding Assay

scholarly journals G6PD deficiency in male individuals infected by Plasmodium vivax malaria in the Brazilian Amazon: a cost study

2015 ◽  
Vol 14 (1) ◽  
Author(s):  
Henry M Peixoto ◽  
Marcelo AM Brito ◽  
Gustavo AS Romero ◽  
Wuelton M Monteiro ◽  
Marcus VG de Lacerda ◽  
...  
Keyword(s):  
Plasmodium Vivax ◽  
G6pd Deficiency ◽  
Vivax Malaria ◽  
Brazilian Amazon ◽  
Cost Study ◽  
Plasmodium Vivax Malaria

scholarly journals Plasmodium vivax Malaria in Pregnant Women in the Brazilian Amazon and the Risk Factors Associated with Prematurity and Low Birth Weight: A Descriptive Study

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0144399 ◽  
Author(s):  
Camila Bôtto-Menezes ◽  
Mônica Caroline Silva dos Santos ◽  
Janicéia Lopes Simplício ◽  
Jandira Menezes de Medeiros ◽  
Kelly Cristina Barroso Gomes ◽  
...  
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Pregnant Women ◽  
Plasmodium Vivax ◽  
Vivax Malaria ◽  
Brazilian Amazon ◽  
Descriptive Study ◽  
Factors Associated ◽  
Plasmodium Vivax Malaria

scholarly journals Evaluation of two Plasmodium vivax sexual stage antigens as transmission-blocking vaccine candidates

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Yongzhe Zhang ◽  
Fei Liu ◽  
Yan Zhao ◽  
Fan Yang ◽  
Jie Bai ◽  
...  
Keyword(s):  
Amino Acids ◽  
Plasmodium Vivax ◽  
Recombinant Proteins ◽  
Expression System ◽  
Anopheles Dirus ◽  
Transmission Blocking ◽  
Yeast Expression System ◽  
Membrane Feeding ◽  
Reducing Activity ◽  
Membrane Feeding Assay

Abstract Background Plasmodium vivax transmission-blocking vaccines (TBVs) are receiving increasing attention. Based on excellent transmission-blocking activities of the PbPH (PBANKA_0417200) and PbSOP26 (PBANKA_1457700) antigens in Plasmodium berghei, their orthologs in P. vivax, PVX_098655 (PvPH) and PVX_101120 (PvSOP26), were selected for the evaluation of their potential as TBVs. Methods Fragments of PvPH (amino acids 22–304) and PvSOP26 (amino acids 30–272) were expressed in the yeast expression system. The recombinant proteins were used to immunize mice to obtain antisera. The transmission-reducing activities of these antisera were evaluated using the direct membrane feeding assay (DMFA) using Anopheles dirus mosquitoes and P. vivax clinical isolates. Results The recombinant proteins PvPH and PvSOP26 induced robust antibody responses in mice. The DMFA showed that the anti-PvSOP26 sera significantly reduced oocyst densities by 92.0 and 84.1% in two parasite isolates, respectively, whereas the anti-PvPH sera did not show evident transmission-reducing activity. The variation in the DMFA results was unlikely due to the genetic polymorphisms of the two genes since their respective sequences were identical in the clinical P. vivax isolates. Conclusion PvSOP26 could be a promising TBV candidate for P. vivax, which warrants further evaluation. Graphical Abstract

scholarly journals TOLLIP gene variant is associated with Plasmodium vivax malaria in the Brazilian Amazon

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Larissa W. Brasil ◽  
Laila R. A. Barbosa ◽  
Felipe J. de Araujo ◽  
Allyson G. da Costa ◽  
Luan D. O. da Silva ◽  
...  
Keyword(s):  
Plasmodium Vivax ◽  
Vivax Malaria ◽  
Brazilian Amazon ◽  
Gene Variant ◽  
Plasmodium Vivax Malaria
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