scholarly journals Resistance Exercise Reverses Aging in Human Skeletal Muscle

PLoS ONE ◽  
2007 ◽  
Vol 2 (5) ◽  
pp. e465 ◽  
Author(s):  
Simon Melov ◽  
Mark A. Tarnopolsky ◽  
Kenneth Beckman ◽  
Krysta Felkey ◽  
Alan Hubbard
Keyword(s):  
Skeletal Muscle ◽  
Resistance Exercise ◽  
Human Skeletal Muscle

scholarly journals Heat stress enhances mTOR signaling after resistance exercise in human skeletal muscle

2011 ◽  
Vol 61 (2) ◽  
pp. 131-140 ◽  
Author(s):  
Ryo Kakigi ◽  
Hisashi Naito ◽  
Yuji Ogura ◽  
Hiroyuki Kobayashi ◽  
Norio Saga ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Heat Stress ◽  
Resistance Exercise ◽  
Human Skeletal Muscle ◽  
Mtor Signaling

Transcriptional Signatures of Human Skeletal Muscle in Response to Aerobic and Resistance Exercise

2017 ◽  
Vol 49 (5S) ◽  
pp. 339
Author(s):  
Jared M. Dickinson ◽  
Andrew C. D’Lugos ◽  
Marcus Naymik ◽  
Matt De Both ◽  
Ashley Siniard ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Resistance Exercise ◽  
Human Skeletal Muscle

scholarly journals Aerobic and resistance exercise training reverses age‐dependent decline in NAD + salvage capacity in human skeletal muscle

2019 ◽  
Vol 7 (12) ◽  
Author(s):  
Roldan M. de Guia ◽  
Marianne Agerholm ◽  
Thomas S. Nielsen ◽  
Leslie A. Consitt ◽  
Ditte Søgaard ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Human Skeletal Muscle ◽  
Resistance Exercise Training ◽  
Age Dependent

The Impact of Acetaminophen Consumption on mTOR Signaling in Human Skeletal Muscle Following Resistance Exercise

2017 ◽  
Vol 49 (5S) ◽  
pp. 801
Author(s):  
Andrew C. D’Lugos ◽  
Shivam H. Patel ◽  
Jordan C. Ormsby ◽  
Tara N. Mahmood ◽  
Don P. Curtis ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Resistance Exercise ◽  
Human Skeletal Muscle ◽  
Mtor Signaling ◽  
The Impact

scholarly journals Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle

Autophagy ◽  
2015 ◽  
Vol 11 (3) ◽  
pp. 538-546 ◽  
Author(s):  
Anna Ulbricht ◽  
Sebastian Gehlert ◽  
Barbara Leciejewski ◽  
Thorsten Schiffer ◽  
Wilhelm Bloch ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Resistance Exercise ◽  
Human Skeletal Muscle ◽  
Selective Autophagy

scholarly journals Resistance Exercise Training Alters Mitochondrial Function in Human Skeletal Muscle

2015 ◽  
Vol 47 (9) ◽  
pp. 1922-1931 ◽  
Author(s):  
CRAIG PORTER ◽  
PAUL T. REIDY ◽  
NISHA BHATTARAI ◽  
LABROS S. SIDOSSIS ◽  
BLAKE B. RASMUSSEN
Keyword(s):  
Skeletal Muscle ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Mitochondrial Function ◽  
Human Skeletal Muscle ◽  
Resistance Exercise Training

scholarly journals Impact of acetaminophen consumption and resistance exercise on extracellular matrix gene expression in human skeletal muscle

2017 ◽  
Vol 313 (1) ◽  
pp. R44-R50 ◽  
Author(s):  
Shivam H. Patel ◽  
Andrew C. D’Lugos ◽  
Erica R. Eldon ◽  
Donald Curtis ◽  
Jared M. Dickinson ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Extracellular Matrix ◽  
Resistance Exercise ◽  
Mrna Expression ◽  
Human Skeletal Muscle ◽  
Type I Collagen ◽  
Type Iii Collagen ◽  
Type I ◽  
Matrix Gene ◽  
The Impact

Acetaminophen (APAP) given during chronic exercise reduces skeletal muscle collagen and cross-linking in rats. We propose that the effect of APAP on muscle extracellular matrix (ECM) may, in part, be mediated by dysregulation of the balance between matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs). The purpose of this study was to evaluate the impact of APAP consumption during acute resistance exercise (RE) on several regulators of the ECM in human skeletal muscle. In a double-blinded, placebo-controlled, randomized crossover design, recreationally active men ( n = 8, 25 ± 2 yr) performed two trials of knee extension. Placebo (PLA) or APAP (1,000 mg/6 h) was given for 24 h before and immediately following RE. Vastus lateralis biopsies were taken at baseline and 1 and 3 h post-RE. Quantitative RT-PCR was used to determine differences in mRNA expression. MMP-2, type I collagen, and type III collagen mRNA expression was not altered by exercise or APAP ( P > 0.05). When compared with PLA, TIMP-1 expression was lower at 1 h post-RE during APAP conditions but greater than PLA at 3 h post-RE ( P < 0.05). MMP-9 expression and protein levels were elevated at 3 h post-RE independent of treatment ( P < 0.05). Lysyl oxidase expression was greater at 3 h post-RE during APAP consumption ( P < 0.05) compared with PLA. MMP-2 and TIMP-1 protein was not altered by RE or APAP ( P > 0.05). Phosphorylation of ERK1/2 and p38-MAPK increased ( P < 0.05) with RE but was not influenced by APAP. Our findings do not support our hypothesis and suggest that short-term APAP consumption before RE has a small impact on the measured ECM molecules in human skeletal muscle following acute RE.

scholarly journals Effect of resistance exercise intensity on the expression of PGC-1α isoforms and the anabolic and catabolic signaling mediators, IGF-1 and myostatin, in human skeletal muscle

2016 ◽  
Vol 41 (8) ◽  
pp. 856-863 ◽  
Author(s):  
Neil A. Schwarz ◽  
Sarah K. McKinley-Barnard ◽  
Mike B. Spillane ◽  
Thomas L. Andre ◽  
Joshua J. Gann ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Resistance Exercise ◽  
Mrna Expression ◽  
Exercise Intensity ◽  
Human Skeletal Muscle ◽  
Peroxisome Proliferator ◽  
Transcriptional Expression ◽  
Lower Intensity ◽  
Peroxisome Proliferator Activated Receptor ◽  
Body Resistance

The purpose of this study was to investigate the acute messenger (mRNA) expression of the peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) isoforms, insulin-like growth factor-1Ea (IGF-1Ea), and myostatin in response to 2 resistance exercise intensities. In a uniform-balanced, crossover design, 10 participants performed 2 separate testing sessions involving a lower body resistance exercise component consisting of a lower intensity (50% of 1-repetition maximum; 1RM) protocol and a higher intensity (80% of 1RM) protocol of equal volumes. Muscle samples were obtained at before exercise, 45 min, 3 h, 24 h, and 48 h postexercise. Resistance exercise did not alter total PGC-1α mRNA expression; however, distinct responses of each PGC-1α isoform were observed. The response of each isoform was consistent between sessions, suggesting no effect of resistance exercise intensity on the complex transcriptional expression of the PGC-1α gene. IGF-1Ea mRNA expression significantly increased following the higher intensity session compared with pre-exercise and the lower intensity session. Myostatin mRNA expression was significantly reduced compared with pre-exercise values at all time points with no difference between exercise intensity. Further research is needed to determine the effects of the various isoforms of PGC-1α in human skeletal muscle on the translational level as well as their relation to the expression of IGF-1 and myostatin.

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