scholarly journals Gallstone Disease Is Associated with More Severe Liver Damage in Patients with Non-Alcoholic Fatty Liver Disease

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e41183 ◽  
Author(s):  
Anna Ludovica Fracanzani ◽  
Luca Valenti ◽  
Maurizio Russello ◽  
Luca Miele ◽  
Cristina Bertelli ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Liver Damage ◽  
Fatty Liver Disease ◽  
Gallstone Disease ◽  
Severe Liver ◽  
Alcoholic Fatty Liver ◽  
Severe Liver Damage ◽  
Alcoholic Fatty Liver Disease

scholarly journals Features of the course of gallstone disease in patients with non-alcoholic fatty liver disease

2020 ◽  
Vol 92 (2) ◽  
pp. 48-54 ◽  
Author(s):  
N. A. Cherkashchenko ◽  
M. A. Livzan ◽  
T. S. Krolevets
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Gallstone Disease ◽  
Alcoholic Fatty Liver ◽  
High Prevalence ◽  
Group 3 ◽  
Alcoholic Fatty Liver Disease

Aim.To update information about comorbidity of non-alcoholic fatty liver disease (NAFLD) and gallstones disease (GD), evaluation of clinical and laboratory data, including insulin, leptin and adiponectin in individuals with NAFLD in combination with GD. Materials and methods.According to the design, we conducted an open comparative study of 169 patients with NAFLD. The following comparison groups were formed: group 1 (n=95) patients with NAFLD without GD, group 2 (n=35) patients with NAFLD and GD and group 3 (n=39) patients with NAFLD, GD and previous cholecystectomy. Results.A high prevalence of coronary heart disease was found in the group of patients with GD and cholecystectomy (2=6.198,p0.05); positive, statistically significant correlation relationships of cholelithiasis, cholecystectomy with ischemic heart disease (rs=0.172,p0.05 andrs=0.241,p0.05, respectively). There was a statistically significant decrease in total bilirubin and total protein in patients of group 3 (H=7.376,p0.03 and H=6.345,p0.04). The level of leptin is statistically significantly higher and positively interrelated with cholecystectomy (H=5.812,p0.05,rs=0.313,p0.05). Conclusion.Patients with NAFLD, GD and previous cholecystectomy have a high prevalence of coronary heart disease; the phenomenon of insulin and leptin resistance, high level of adiponectin were revealed in patients with NAFLD and gallstones; hyperleptinemia was observed among patients with NAFLD, GD after cholecystectomy.

scholarly journals S0993 Association of Non-Alcoholic Fatty Liver Disease With Gallstone Disease in the U.S. Population

2020 ◽  
Vol 115 (1) ◽  
pp. S505-S505
Author(s):  
Shantanu Solanki ◽  
Asim Kichloo ◽  
Michael Albosta ◽  
Michael Aljadah ◽  
Beth Bailey ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Gallstone Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease ◽  
The U.S

scholarly journals Intestinal permeability in the pathogenesis of liver damage: From non-alcoholic fatty liver disease to liver transplantation

2019 ◽  
Vol 25 (33) ◽  
pp. 4814-4834 ◽  
Author(s):  
Alberto Nicoletti ◽  
Francesca Romana Ponziani ◽  
Marco Biolato ◽  
Venanzio Valenza ◽  
Giuseppe Marrone ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Disease ◽  
Fatty Liver ◽  
Intestinal Permeability ◽  
Liver Damage ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Mo1436 GALLSTONE DISEASE IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE: THE METABOLIC RISKS

2020 ◽  
Vol 158 (6) ◽  
pp. S-876
Author(s):  
Maria Livzan ◽  
Natalya Cherkashchenko ◽  
Tatyana Krolevets ◽  
Daria Popello
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Gallstone Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Sarcopenia is associated with severe liver fibrosis in patients with non-alcoholic fatty liver disease

2016 ◽  
Vol 45 (4) ◽  
pp. 510-518 ◽  
Author(s):  
S. Petta ◽  
S. Ciminnisi ◽  
V. Di Marco ◽  
D. Cabibi ◽  
C. Cammà ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Severe Liver ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease

Gut ◽  
2010 ◽  
Vol 59 (2) ◽  
pp. 267-273 ◽  
Author(s):  
P Dongiovanni ◽  
L Valenti ◽  
R Rametta ◽  
A K Daly ◽  
V Nobili ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Liver Disease ◽  
Fatty Liver ◽  
Insulin Receptor ◽  
Liver Damage ◽  
Fatty Liver Disease ◽  
Insulin Signalling ◽  
Receptor Activity ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Background/aimsThe aim of this study was to assess the effect of functional ENPP1(ectoenzyme nucleotide pyrophosphate phosphodiesterase 1)/PC-1 (plasma cell antigen-1) and IRS-1 (insulin receptor substrate-1) polymorphisms influencing insulin receptor activity on liver damage in non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome, whose progression is associated with the severity of insulin resistance.Patients and methods702 patients with biopsy-proven NAFLD from Italy and the UK, and 310 healthy controls. The Lys121Gln ENPP1/PC-1 and the Gly972Arg IRS-1 polymorphisms were evaluated by restriction analysis. Fibrosis was evaluated according to Kleiner. Insulin signalling activity was evaluated by measuring phosphoAKT levels by western blotting in a subset of obese non-diabetic patients.ResultsThe ENPP1 121Gln and IRS-1 972Arg polymorphisms were detected in 28.7% and 18.1% of patients and associated with increased body weight/dyslipidaemia and diabetes risk, respectively. The ENPP1 121Gln allele was significantly associated with increased prevalence of fibrosis stage >1 and >2, which was higher in subjects also positive for the 972Arg IRS-1 polymorphism. At multivariate analysis, the presence of the ENPP1 121Gln and IRS-1 972Arg polymorphisms was independently associated with fibrosis >1 (OR 1.55, 95% CI 1.24 to 1.97; and OR 1.57, 95% CI 1.12 to 2.23, respectively). Both polymorphisms were associated with a marked reduction of ∼70% of AKT activation status, reflecting insulin resistance and disease severity, in obese patients with NAFLD.ConclusionsThe ENPP1 121Gln and IRS-1 972Arg polymorphisms affecting insulin receptor activity predispose to liver damage and decrease hepatic insulin signalling in patients with NAFLD. Defective insulin signalling may play a causal role in the progression of liver damage in NAFLD.

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