S0993 Association of Non-Alcoholic Fatty Liver Disease With Gallstone Disease in the U.S. Population

Aim.To update information about comorbidity of non-alcoholic fatty liver disease (NAFLD) and gallstones disease (GD), evaluation of clinical and laboratory data, including insulin, leptin and adiponectin in individuals with NAFLD in combination with GD. Materials and methods.According to the design, we conducted an open comparative study of 169 patients with NAFLD. The following comparison groups were formed: group 1 (n=95) patients with NAFLD without GD, group 2 (n=35) patients with NAFLD and GD and group 3 (n=39) patients with NAFLD, GD and previous cholecystectomy. Results.A high prevalence of coronary heart disease was found in the group of patients with GD and cholecystectomy (2=6.198,p0.05); positive, statistically significant correlation relationships of cholelithiasis, cholecystectomy with ischemic heart disease (rs=0.172,p0.05 andrs=0.241,p0.05, respectively). There was a statistically significant decrease in total bilirubin and total protein in patients of group 3 (H=7.376,p0.03 and H=6.345,p0.04). The level of leptin is statistically significantly higher and positively interrelated with cholecystectomy (H=5.812,p0.05,rs=0.313,p0.05). Conclusion.Patients with NAFLD, GD and previous cholecystectomy have a high prevalence of coronary heart disease; the phenomenon of insulin and leptin resistance, high level of adiponectin were revealed in patients with NAFLD and gallstones; hyperleptinemia was observed among patients with NAFLD, GD after cholecystectomy.

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Associations of acrylamide with non-alcoholic fatty liver disease in American adults: a nationwide cross-sectional study

Environmental Health ◽

10.1186/s12940-021-00783-2 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Zhening Liu ◽

Jinghua Wang ◽

Shenghui Chen ◽

Chengfu Xu ◽

Yu Zhang

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Cross Sectional Study ◽

Cross Sectional ◽

Alcoholic Fatty Liver ◽

Negatively Associated ◽

Smoking Group ◽

Alcoholic Fatty Liver Disease ◽

The U.S

Abstract Background Acrylamide (AA) is a toxicant to humans, but the association between AA exposure and the risk of non-alcoholic fatty liver disease (NAFLD) remains unclear. In this study, our objective is to examine the cross-sectional association between AA exposure and the risk of NAFLD in American adults. Methods A total of 3234 individuals who took part in the National Health and Nutrition Examination Survey (NHANES) 2003–2006 and 2013–2016 were enrolled in the study. NAFLD was diagnosed by the U.S. Fatty Liver Index. Multivariable logistic regression models were applied to estimate the association between AA and NAFLD in the whole group and the non-smoking group. Results We discovered that in the whole group, serum hemoglobin adducts of AA (HbAA) were negatively associated with the prevalence of NAFLD after adjustment for various covariables (P for trend < 0.001). Compared with individuals in the lowest HbAA quartiles, the odds ratios (ORs) with 95% confidence intervals (CIs) in the highest HbAA quartiles were 0.61 (0.46–0.81) and 0.57 (0.36–0.88) in the whole group and the non-smoking group, respectively. In contrast, HbGA/HbAA showed a significantly positive correlation with the prevalence of NAFLD in both groups (P for trend < 0.001). In addition, HbGA was not significantly associated with NAFLD in the whole group or the non-smoking group. Conclusions HbAA is negatively associated with NAFLD whereas HbGA/HbAA is positively associated with NAFLD in adults in the U.S. Further studies are needed to clarify these relationships.

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Mo1436 GALLSTONE DISEASE IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE: THE METABOLIC RISKS

Gastroenterology ◽

10.1016/s0016-5085(20)32878-x ◽

2020 ◽

Vol 158 (6) ◽

pp. S-876

Author(s):

Maria Livzan ◽

Natalya Cherkashchenko ◽

Tatyana Krolevets ◽

Daria Popello

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Gallstone Disease ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

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681 Routine Liver Biopsy to Detect Non-Alcoholic Fatty Liver Disease (NAFLD) During Laparoscopic Cholecystectomy for Symptomatic Gallstone Disease (GD). Is It Justified?

Gastroenterology ◽

10.1016/s0016-5085(08)63995-5 ◽

2008 ◽

Vol 134 (4) ◽

pp. A-853

Author(s):

Antonio Ramos-De la Medina ◽

Federico B. Roesch ◽

Alfonso Perez Morales ◽

Silvia Cid-Juarez ◽

Jose M. Remes-Troche

Keyword(s):

Laparoscopic Cholecystectomy ◽

Liver Disease ◽

Liver Biopsy ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Gallstone Disease ◽

Alcoholic Fatty Liver ◽

Symptomatic Gallstone Disease ◽

Alcoholic Fatty Liver Disease

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Bidirectional Associations Among Gallstone Disease, Non-Alcoholic Fatty Liver Disease, and Kidney Stone Disease

SSRN Electronic Journal ◽

10.2139/ssrn.3971000 ◽

2021 ◽

Author(s):

Xin Wang ◽

Yutong Wang ◽

Lingxi Kong ◽

Chi Zhang ◽

Yanmei Lou ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Kidney Stone ◽

Fatty Liver Disease ◽

Gallstone Disease ◽

Stone Disease ◽

Alcoholic Fatty Liver ◽

Kidney Stone Disease ◽

Bidirectional Associations ◽

Alcoholic Fatty Liver Disease

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Prevalence of non-alcoholic fatty liver disease and hypercholesterolemia in patients of gallstone disease undergoing laparoscopic cholecystectomy

Polish Journal of Surgery ◽

10.5604/01.3001.0013.5660 ◽

2019 ◽

Vol 92 (1) ◽

pp. 1-5

Author(s):

Kaptan Singh ◽

Divya Dahiya ◽

Lileswar Kaman ◽

Ashim Das

Keyword(s):

Laparoscopic Cholecystectomy ◽

Liver Disease ◽

Liver Biopsy ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Gallstone Disease ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

Background Gallstone disease (GSD) and non alcoholic fatty liver disease (NAFLD) has high prevalence in the general population and they share the common risk factors for their occurrence. Limited literature with inconsistent results is available suggesting the potential association between these life style induced diseases. Liver biopsy is the gold standard for diagnosing NAFLD. Aim of this study was (1) to identify the prevalence of asymptomatic NAFLD or NASH in liver biopsy specimen; (2) to identify association of hypercholesterolemia with NAFLD in patients undergoing laparoscopic cholecystectomy (LC). Methods This is a prospective observational study conducted on patients who underwent LC for symptomatic gallstones in the Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh from 1st July 2013 to 31st December 2014. All included patients had ultrasonography (USG); serum triglycerides (TG), cholesterol, low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol. A wedge liver biopsy was obtained from free edge of right liver lobe during LC and all biopsy specimens were analyzed by single pathologist. Results Dyslipidemia was present in 49.50% of 101 included patients. There was no association between NAFLD and serum cholesterol, TG or LDL-C (p 0.428, 0.848, 0.371 respectively). NAFLD was confirmed on liver biopsy in 21.8%; but none had fibrosis and cirrhosis on biopsy. There was no complication observed following liver biopsy. Conclusions Liver biopsy during LC gives an opportunity to diagnose the disease at an early and reversible stage. It is feasible, safe and cost effective.

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Hepatobiliary continuum: non-alcoholic fatty liver disease, cholelithiasis ... what else?

Medical Council ◽

10.21518/2079-701x-2021-15-68-76 ◽

2021 ◽

pp. 68-76

Author(s):

A. O. Bueverov

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Biliary Tract ◽

Fatty Liver Disease ◽

Gallstone Disease ◽

Bacterial Overgrowth ◽

Farnesoid X Receptor ◽

Alcoholic Fatty Liver ◽

Increased Risk ◽

Alcoholic Fatty Liver Disease

The relationship between metabolic non-alcoholic fatty liver disease (NAFLD) and gallstone disease (GSD) is complex and seemingly interrelated. There is no doubt that there is an increased risk of cholelithiasis in patients with NAFLD, which is primarily associated with general pathogenetic mechanisms. These include central and peripheral insulin resistance, changes in the expression of transcription factors (hepatic X-receptor, farnesoid X-receptor (FXR) and membrane bile acid receptors (TGR5)). At the same time, the effect of gallstone disease on the course of NAFLD is assumed, although the pathogenetic factors of this association are still insufficient. There are accumulating data on an increased risk of other pathologies of the biliary tract in patients with NAFLD, in particular, of gallbladder polyps and tumors of the biliary tract. Recently there have been convincing data on the role of cholecystectomy in the progression of NAFLD, which may be due to disruption of endocrine balance and signaling function of bile acids, as well as the development of bacterial overgrowth in the small intestine. General therapeutic approaches to the treatment of interrelated hepatobiliary pathology may include new generation insulinsensitizers, FXR agonists, and ursodeoxycholic acid. The link between NAFLD and the pathology of the biliary tract is complex and multifaceted, and its further study opens up prospects for the development of new methods of treatment.

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