scholarly journals Time Course of Central and Peripheral Alterations after Isometric Neuromuscular Electrical Stimulation-Induced Muscle Damage

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e107298 ◽  
Author(s):  
Alexandre Fouré ◽  
Kazunori Nosaka ◽  
Jennifer Wegrzyk ◽  
Guillaume Duhamel ◽  
Arnaud Le Troter ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Muscle Damage ◽  
Time Course ◽  
Neuromuscular Electrical Stimulation

Individualized isometric neuromuscular electrical stimulation training promotes myonuclear accretion in mouse skeletal muscle

2021 ◽  
Author(s):  
Aliki Zavoriti ◽  
Aurélie Fessard ◽  
Masoud Rahmati ◽  
Peggy Del Carmine ◽  
Bénédicte Chazaud ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Electrical Stimulation ◽  
Muscle Damage ◽  
Neuromuscular Electrical Stimulation ◽  
Training Session ◽  
Force Production ◽  
Main Function ◽  
Muscle Stem Cells ◽  
Exercise Induced ◽  
Electrical Stimuli

Skeletal muscle is a plastic tissue that adapts to exercise through fusion of muscle stem cells (MuSCs) with myofibers, a physiological process referred to as myonuclear accretion. However, it is still unclear whether myonuclear accretion is driven by increased mechanical loading per se , or occurs, at least in part, in response to exercise-induced muscle injury. Here, we developed a carefully monitored and individualized neuromuscular electrical stimulation (NMES) training protocol of the mouse plantar flexor muscles. Each NMES training session consisted of 80 isometric contractions at a submaximal mechanical intensity corresponding to ≈15% of maximal tetanic force to avoid muscle damage. NMES trained mice were stimulated for 2 × 3 consecutive days separated by one day of rest, for a total of 6 sessions. Experiments were conducted on C57BL/6J and BALB/c males at 10-12 weeks of age. NMES led to a robust myonuclear accretion and higher MuSC content in gastrocnemius muscle of both mouse lines, without overt signs of muscle damage/regeneration or muscle hypertrophy or force improvement. This new mouse model of myonuclear accretion relying on the main function of skeletal muscles, i.e., force production in response to electrical stimuli, will be of utmost interest to further understand the role of MuSCs in skeletal muscle adaptations.

Decreased excitability of motor axons contributes substantially to contraction fatigability during neuromuscular electrical stimulation

2020 ◽  
Author(s):  
Minh John Luu ◽  
Kelvin E. Jones ◽  
David F. Collins
Keyword(s):  
Electrical Stimulation ◽  
Time Course ◽  
Tibialis Anterior Muscle ◽  
Neuromuscular Electrical Stimulation ◽  
Motor Units ◽  
Drop Out ◽  
Motor Axon ◽  
Dependent Manner ◽  
Motor Axons ◽  
Axonal Excitability

The present study was designed to: 1) determine the time course of changes in motor axon excitability during and after neuromuscular electrical stimulation (NMES), and 2) characterise the relationship between contraction fatigability, NMES frequency, and changes at the axon, neuromuscular junction, and muscle. Eight neurologically-intact participants attended three sessions. NMES was delivered over the common peroneal nerve at 20, 40, or 60 Hz for 8 min (0.3 s “on”, 0.7 s “off”). Threshold tracking was used to measure changes in axonal excitability. Supramaximal stimuli were used to assess neuromuscular transmission and force-generating capacity of the tibialis anterior muscle. Torque decreased 49 and 62% during 8 min of 40 and 60 Hz NMES, respectively. Maximal twitch torque decreased only during 60 Hz NMES. Motor axon excitability decreased by 14, 27, and 35% during 20, 40, and 60 Hz NMES, respectively. Excitability recovered to baseline immediately (20 Hz), 2 min (40 Hz), and 4 min (60 Hz) following NMES. Overall, decreases in axonal excitability best predicted how torque declined over 8 min of NMES. During NMES, motor axons become less excitable and motor units “drop out” of the contraction, contributing substantially to contraction fatigability and its dependence on NMES frequency. NOVELTY BULLETS • The excitability of motor axons decreased during neuromuscular electrical stimulation (NMES) in a frequency-dependent manner. • As excitability decreased, axons failed to reach threshold and motor units dropped out of the contraction. • Overall, decreased excitability best predicted how torque declined and thus is a key contributor to fatigability during NMES.

scholarly journals The effect of low level laser irradiation on oxidative stress, muscle damage and function following neuromuscular electrical stimulation. A double blind, randomised, crossover trial

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Ewa Jówko ◽  
Maciej Płaszewski ◽  
Maciej Cieśliński ◽  
Tomasz Sacewicz ◽  
Igor Cieśliński ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Electrical Stimulation ◽  
Muscle Damage ◽  
Redox State ◽  
Crossover Trial ◽  
Neuromuscular Electrical Stimulation ◽  
Trial Registration ◽  
Double Blind ◽  
Enzymatic Antioxidant ◽  
Level Laser

Abstract Background Low level laser therapy (LLLT) is among novel methods for preventing and treating muscle damage and soreness induced by volitional exercise, but little is known about using LLLT before neuromuscular electrical stimulation. The aim of this first randomised, double blind, crossover trial addressing this issue was to evaluate effects of LLLT on muscle damage and oxidative stress, as well as recovery of muscle function after a single session of isometric neuromuscular electrical stimulation(NMES). Methods Twenty four moderately active, healthy men aged 21–22 years received 45 electrically evoked tetanic, isometric contractions of the quadriceps femoris, preceded by LLLT or sham-LLLT. Maximal isometric voluntary muscle torques, perceived soreness, and blood samples were analysed from baseline to 96 h post intervention. We measured plasma markers of muscle damage (the activity of creatine kinase), and inflammation (C-reactive protein), and evaluated redox state parameters. Results NMES-evoked contractions induced oxidative stress, demonstrated by an increase in lipid peroxidation and impairments in enzymatic antioxidant system. LLLT irradiations had a protective effect on NMES-induced decrease in enzymatic antioxidant defence and shortened the duration of inflammation. This effect of irradiations on redox state and inflammation did not affect lipid peroxidation, muscle damage, and muscle torque. Conclusions LLLT may protect from impairments in enzymatic antioxidant system and may shorten inflammation induced by a single NMES session in moderately active, healthy men. However, the effects of LLLT on redox state and inflammatory processes do not seem to affect muscle damage and recovery of muscle function after NMES. Trial registration The study was retrospectively registered in the Australian New Zealand Clinical Trials Registry (ANZCTR); The trial registration number: ACTRN12619000678190; date of registration: 6 May 2019.

Neuromuscular electrical stimulation as an alternative to physical exercise in patients with COPD

2018 ◽  
pp. 59-64
Author(s):  
T. V. Kunafina ◽  
◽  
A. G. Chuchalin ◽  
A. S. Belevsky ◽  
N. N. Mescheryakova ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Physical Exercise ◽  
Neuromuscular Electrical Stimulation

Preliminary outcomes in transcutaneous neuromuscular electrical stimulation use in patients with dysphagia

2018 ◽  
Vol 8 (31) ◽  
pp. 167-174
Author(s):  
Codrut Sarafoleanu ◽  
Raluca Enache
Keyword(s):  
Traumatic Brain Injury ◽  
Head And Neck Cancer ◽  
Electrical Stimulation ◽  
Neurodegenerative Disorders ◽  
Structural Changes ◽  
Congenital Abnormalities ◽  
Neuromuscular Electrical Stimulation ◽  
Therapy Options ◽  
Dysphagia Treatment ◽  
Risk Of Aspiration

Abstract Dysphagia is a common disorder associated with a large number of etiologies like aging, stroke, traumatic brain injury, head and neck cancer, neurodegenerative disorders, structural changes or congenital abnormalities. The type of the treatment and its results depend on the type, severity and the cause of dysphagia. The primary goal of dysphagia treatment is to improve the swallowing process and decrease the risk of aspiration. Along with the existing rehabilitation swallowing treatments, new adjunctive therapy options developed, one of them being the neuromuscular electrical stimulation (NMES). The authors present the principles of NMES, a small literature review about the results of this therapy and their experience in using transcutaneous NMES in dysphagia patients.

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