scholarly journals Reduced Adolescent-Age Spatial Learning Ability Associated with Elevated Juvenile-Age Superoxide Levels in Complex I Mouse Mutants

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0123863 ◽  
Author(s):  
Johannes Mayer ◽  
Gesine Reichart ◽  
Tursonjan Tokay ◽  
Falko Lange ◽  
Simone Baltrusch ◽  
...  
Keyword(s):  
Spatial Learning ◽  
Complex I ◽  
Learning Ability ◽  
Mouse Mutants ◽  
Juvenile Age

scholarly journals The role of dietary niacin intake and the adenosine-5′-diphosphate-ribosyl cyclase enzyme CD38 in spatial learning ability: is cyclic adenosine diphosphate ribose the link between diet and behaviour?

2008 ◽  
Vol 21 (1) ◽  
pp. 42-55 ◽  
Author(s):  
Genevieve S. Young ◽  
James B. Kirkland
Keyword(s):  
Spatial Learning ◽  
Young Male ◽  
Adenosine Diphosphate ◽  
Pyridine Nucleotide ◽  
Learning Ability ◽  
Learning Performance ◽  
Male Rats ◽  
Current Evidence ◽  
Niacin Deficiency ◽  
The Brain

The pyridine nucleotide NAD+is derived from dietary niacin and serves as the substrate for the synthesis of cyclic ADP-ribose (cADPR), an intracellular Ca signalling molecule that plays an important role in synaptic plasticity in the hippocampus, a region of the brain involved in spatial learning. cADPR is formed in part via the activity of the ADP-ribosyl cyclase enzyme CD38, which is widespread throughout the brain. In the present review, current evidence of the relationship between dietary niacin and behaviour is presented following investigations of the effect of niacin deficiency, pharmacological nicotinamide supplementation and CD38 gene deletion on brain nucleotides and spatial learning ability in mice and rats. In young male rats, both niacin deficiency and nicotinamide supplementation significantly altered brain NAD+and cADPR, both of which were inversely correlated with spatial learning ability. These results were consistent across three different models of niacin deficiency (pair feeding, partially restricted feeding and niacin recovery). Similar changes in spatial learning ability were observed inCd38− / − mice, which also showed decreases in brain cADPR. These findings suggest an inverse relationship between spatial learning ability, dietary niacin intake and cADPR, although a direct link between cADPR and spatial learning ability is still missing. Dietary niacin may therefore play a role in the molecular events regulating learning performance, and further investigations of niacin intake, CD38 and cADPR may help identify potential molecular targets for clinical intervention to enhance learning and prevent or reverse cognitive decline.

Correlation of increased hippocampal Sumo3 with spatial learning ability in old C57BL/6 mice

2012 ◽  
Vol 518 (2) ◽  
pp. 75-79 ◽  
Author(s):  
Qi-Gang Yang ◽  
Fang Wang ◽  
Qiong Zhang ◽  
Wen-Rui Xu ◽  
Yong-Ping Chen ◽  
...  
Keyword(s):  
Spatial Learning ◽  
Learning Ability

scholarly journals Bamboo leaf extract improves spatial learning ability in a rat model with senile dementia

2015 ◽  
Vol 16 (7) ◽  
pp. 593-601 ◽  
Author(s):  
Jian-xiang Liu ◽  
Min-ying Zhu ◽  
Ci-yuan Feng ◽  
Hai-bin Ding ◽  
Ying Zhan ◽  
...  
Keyword(s):  
Spatial Learning ◽  
Rat Model ◽  
Leaf Extract ◽  
Senile Dementia ◽  
Learning Ability
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