scholarly journals Maternal Obesity, Overweight and Gestational Diabetes Affect the Offspring Neurodevelopment at 6 and 18 Months of Age – A Follow Up from the PREOBE Cohort

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0133010 ◽  
Author(s):  
Francisco J. Torres-Espinola ◽  
Staffan K Berglund ◽  
Luz Mª García-Valdés ◽  
Mª Teresa Segura ◽  
Antonio Jerez ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Maternal Obesity

Maternal obesity and gestational diabetes alter fatty acids during pregnancy – the preobe follow up

2018 ◽  
Vol 37 ◽  
pp. S292
Author(s):  
A. de la Garza Puentes ◽  
M. Olivares-de Anda ◽  
A.M. Chisaguano Tonato ◽  
R. Montes Goyanes ◽  
M. Bonilla Aguirre ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Gestational Diabetes ◽  
Maternal Obesity

scholarly journals Maternal obesity and gestational diabetes: Impact on arterial wall layer thickness and stiffness in early childhood - RADIEL study six-year follow-up

2019 ◽  
Vol 284 ◽  
pp. 237-244 ◽  
Author(s):  
Johnny K.M. Sundholm ◽  
Linda Litwin ◽  
Kristiina Rönö ◽  
Saila B. Koivusalo ◽  
Johan G. Eriksson ◽  
...  
Keyword(s):  
Early Childhood ◽  
Gestational Diabetes ◽  
Layer Thickness ◽  
Arterial Wall ◽  
Maternal Obesity ◽  
Wall Layer

Lack of postpartum reclassification test in gestational diabetes - factors conditioning loss of follow-up

2017 ◽  
Author(s):  
Rita Bettencourt-Silva ◽  
Pedro Souteiro ◽  
Daniela Magalhaes ◽  
Sandra Belo ◽  
Ana Oliveira ◽  
...  
Keyword(s):  
Gestational Diabetes

Postpartum Tip 2 DM follow-up after gestational diabetes mellitus

2017 ◽  
Author(s):  
Seda Sancak ◽  
Ali Ozdemir ◽  
Kerem Yiğit Abacar ◽  
Ayhan Celik ◽  
Nalan Okuroğlu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus

Gestational diabetes mellitus: are mothers being followed-up? A retrospective study

2018 ◽  
Vol 68 (suppl 1) ◽  
pp. bjgp18X697469
Author(s):  
Rebecca Ward ◽  
Fahmy W Hanna ◽  
Ann Shelley-Hitchen ◽  
Ellen Hodgson ◽  
Adrian Heald ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Median Time ◽  
Post Partum ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Tertiary Referral Centre ◽  
Alternative Approach ◽  
Nice Guidance ◽  
History Of

BackgroundWomen with gestational diabetes (GDM) have an elevated risk of developing type 2 diabetes (T2DM). NICE Guidance recommends women who develop GDM are screened 6 weeks post-partum and annually thereafter.AimTo evaluate conformity to guidance of screening in women with GDM by 6-week post-partum fasting plasma glucose (FPG) and annual FPG and determine time between delivery and development of T2DM.MethodRecords at a tertiary referral centre were used to identify women (n = 54) diagnosed with GDM by antenatal oral glucose tolerance test between July 1999 and January 2007. Data from laboratory records were used to collect investigations of glycaemic status during the follow-up period (median follow-up 12.4 years, range 9.5–17.1 years).ResultsOf 252 women, 102 (40.2%) did not have a FPG at 6 weeks (+/−2 weeks). Of these, median time to first test was 1.2 years (range 0.04–10.8 years), with only 43.1% followed-up within 1 year. In those who had a 6-week FPG, 17 (11.3%) women had no further tests. A total of 84 (33% of those with gestational diabetes in the index pregnancy) women were diagnosed with T2DM; median time from delivery to diagnosis was 5.2 years (range 0.35–15.95). We found the only significant factor for a follow-up test at 1-year post-partum was the use of insulin.ConclusionOur data suggest an alternative approach is needed for monitoring women with a history of GDM. This needs to be appropriate for a generally healthy group in which traditional screening mechanisms may not be adequate or sufficient.

Effects of Maternal Obesity and Gestational Diabetes Mellitus on the Placenta: Current Knowledge and Targets for Therapeutic Interventions

2020 ◽  
Vol 19 (2) ◽  
pp. 176-192
Author(s):  
Samantha Bedell ◽  
Janine Hutson ◽  
Barbra de Vrijer ◽  
Genevieve Eastabrook
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Maternal Obesity ◽  
Environmental Changes ◽  
Current Knowledge ◽  
Therapeutic Interventions ◽  
Placental Development ◽  
Exchange Site ◽  
And Function

: Obesity and gestational diabetes mellitus (GDM) are becoming more common among pregnant women worldwide and are individually associated with a number of placenta-mediated obstetric complications, including preeclampsia, macrosomia, intrauterine growth restriction and stillbirth. The placenta serves several functions throughout pregnancy and is the main exchange site for the transfer of nutrients and gas from mother to fetus. In pregnancies complicated by maternal obesity or GDM, the placenta is exposed to environmental changes, such as increased inflammation and oxidative stress, dyslipidemia, and altered hormone levels. These changes can affect placental development and function and lead to abnormal fetal growth and development as well as metabolic and cardiovascular abnormalities in the offspring. This review aims to summarize current knowledge on the effects of obesity and GDM on placental development and function. Understanding these processes is key in developing therapeutic interventions with the goal of mitigating these effects and preventing future cardiovascular and metabolic pathology in subsequent generations.

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