scholarly journals Evaluating the Effectiveness of an Antimicrobial Stewardship Program on Reducing the Incidence Rate of Healthcare-Associated Clostridium difficile Infection: A Non-Randomized, Stepped Wedge, Single-Site, Observational Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0157671 ◽  
Author(s):  
Giulio DiDiodato ◽  
Leslie McArthur
Keyword(s):  
Clostridium Difficile ◽  
Observational Study ◽  
Incidence Rate ◽  
Clostridium Difficile Infection ◽  
Antimicrobial Stewardship ◽  
Single Site ◽  
Antimicrobial Stewardship Program ◽  
Stepped Wedge ◽  
Stewardship Program ◽  
Healthcare Associated

scholarly journals Impact of an antimicrobial stewardship program on healthcare-associated Clostridium difficile rates at a community-based teaching hospital

2018 ◽  
Vol 19 (4) ◽  
pp. 191-194 ◽  
Author(s):  
Matthew A Moffa ◽  
Thomas L Walsh ◽  
Amy Tang ◽  
Derek N Bremmer
Keyword(s):  
Clostridium Difficile ◽  
Teaching Hospital ◽  
Antimicrobial Stewardship ◽  
Intervention Study ◽  
Antimicrobial Stewardship Program ◽  
Post Intervention ◽  
Community Based ◽  
Stewardship Program ◽  
Before And After ◽  
Healthcare Associated

We conducted a pre-intervention/post-intervention study to assess the rate of healthcare-associated Clostridium difficile infections (HA-CDI) before and after the implementation of an antimicrobial stewardship program (ASP). Upon implementation of our ASP, the usage of targeted antimicrobials, including ceftriaxone, clindamycin, fluoroquinolones and carbapenem antibiotics, were significantly reduced. There was also a significant reduction in HA-CDI/1000 patient-days following ASP implementation (0.84 vs. 0.28; P = 0.035).

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