scholarly journals Correction: Rapid Progressing Allele HLA-B35 Px Restricted Anti-HIV-1 CD8+ T Cells Recognize Vestigial CTL Epitopes

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0160293 ◽  
Author(s):  
Christian B. Willberg ◽  
Keith E. Garrison ◽  
R. Brad Jones ◽  
Duncan A. Meiklejohn ◽  
Gerald Spotts ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Ctl Epitopes ◽  
Anti Hiv ◽  
Hiv 1

scholarly journals Rapid Progressing Allele HLA-B35 Px Restricted Anti-HIV-1 CD8+ T Cells Recognize Vestigial CTL Epitopes

PLoS ONE ◽  
2010 ◽  
Vol 5 (4) ◽  
pp. e10249 ◽  
Author(s):  
Christian B. Willberg ◽  
Keith E. Garrison ◽  
R. Brad Jones ◽  
Duncan J. Meiklejohn ◽  
Gerald Spotts ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Ctl Epitopes ◽  
Anti Hiv ◽  
Hiv 1

scholarly journals Identification of Effective Subdominant Anti-HIV-1 CD8+ T Cells Within Entire Post-infection and Post-vaccination Immune Responses

2015 ◽  
Vol 11 (2) ◽  
pp. e1004658 ◽  
Author(s):  
Gemma Hancock ◽  
Hongbing Yang ◽  
Elisabeth Yorke ◽  
Emma Wainwright ◽  
Victoria Bourne ◽  
...  
Keyword(s):  
T Cells ◽  
Immune Responses ◽  
Cd8 T Cells ◽  
Post Infection ◽  
Post Vaccination ◽  
Anti Hiv ◽  
Hiv 1

Suppression of HIV replication in vitro by CD8+ T-cells from HIV-infected and HIV-seronegative individuals

1997 ◽  
Vol 8 (5) ◽  
pp. 307-310 ◽  
Author(s):  
H Ichimura ◽  
J M Dwyer ◽  
H Tsuchie ◽  
M A Detorio ◽  
M M Hossain ◽  
...  
Keyword(s):  
T Cells ◽  
Nucleotide Sequence ◽  
Cd8 T Cells ◽  
Cd4 T Cells ◽  
Inhibitory Effect ◽  
Hiv Replication ◽  
Anti Hiv ◽  
Hiv 1 ◽  
New Strategies

The inhibitory effect of CD8+ T-cells from HIV-infected or HIVseronegative individuals on HIV replication in the naturally-infected CD4+ T-cells in vitro was examined. Not only autologous CD8+ T-cells from HIV-infected individuals but also allogeneic CD8+ T-cells from HIV-seronegative individuals prevented or delayed HIV replication, even in transwell cocultures using a semipermeable 0.45 micron filter. The level of the inhibitory effect of allogeneic CD8+ Tcells from the HIV-seronegative individuals on the HIV replication was varied among CD4+ T-cells obtained from HIV-infected individuals used. The results suggested that CD8+ T-cells from HIV-seronegative individuals as well as HIVinfected individuals could produce some cytokine(s) which suppress HIV replication in vitro . The sensitivity to the cytokine(s) might be variable among HIV strains, depending on differences in the nucleotide sequence of different HIV-1 strains. Further studies of control of HIV replication by CD8+ anti-HIV cytokine(s) should provide new strategies for the therapy of HIV infection.

scholarly journals Elimination of SHIV Infected Cells by Combinations of Bispecific HIVxCD3 DART® Molecules

2021 ◽  
Vol 12 ◽  
Author(s):  
Marina Tuyishime ◽  
Amir Dashti ◽  
Katelyn Faircloth ◽  
Shalini Jha ◽  
Jeffrey L. Nordstrom ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Cd4 T Cells ◽  
Ex Vivo ◽  
Viral Envelope ◽  
Host Immune System ◽  
Infected Cells ◽  
Anti Hiv ◽  
Hiv 1

Bispecific HIVxCD3 DART molecules that co-engage the viral envelope glycoprotein (Env) on HIV-1-infected cells and the CD3 receptor on CD3+ T cells are designed to mediate the cytolysis of HIV-1-infected, Env-expressing cells. Using a novel ex vivo system with cells from rhesus macaques (RMs) infected with a chimeric Simian-Human Immunodeficiency Virus (SHIV) CH505 and maintained on ART, we tested the ability of HIVxCD3 DART molecules to mediate elimination of in vitro-reactivated CD4+ T cells in the absence or presence of autologous CD8+ T cells. HIVxCD3 DART molecules with the anti-HIV-1 Env specificities of A32 or 7B2 (non-neutralizing antibodies) or PGT145 (broadly neutralizing antibody) were evaluated individually or combined. DART molecule-mediated antiviral activity increased significantly in the presence of autologous CD8+ T cells. In this ex vivo system, the PGT145 DART molecule was more active than the 7B2 DART molecule, which was more active than the A32 DART molecule. A triple combination of the DART molecules exceeded the activity of the individual PGT145 DART molecule. Modified quantitative virus outgrowth assays confirmed the ability of the DART molecules to redirect RM CD3+ T cells to eliminate SHIV-infected RM CD4+ T cells as demonstrated by the decreased propagation of in vitro infection by the infected cells pre-incubated with DART molecules in presence of effector CD8+ T cells. While mediating cytotoxic activity, DART molecules did not increase proinflammatory cytokine production. In summary, combination of HIVxCD3 DART molecules that have broadly-neutralizing and non-neutralizing anti-HIV-1 Env specificities can leverage the host immune system for treatment of HIV-1 infection but will require appropriate reactivation of the latent reservoir.

scholarly journals Ectopic expression of anti-HIV-1 shRNAs protects CD8 + T cells modified with CD4ζ CAR from HIV-1 infection and alleviates impairment of cell proliferation

2015 ◽  
Vol 463 (3) ◽  
pp. 216-221 ◽  
Author(s):  
Masakazu Kamata ◽  
Patrick Y. Kim ◽  
Hwee L. Ng ◽  
Gene-Errol E. Ringpis ◽  
Emiko Kranz ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
T Cells ◽  
Cd8 T Cells ◽  
Ectopic Expression ◽  
Anti Hiv ◽  
Hiv 1

IL-8 responsiveness defines a subset of CD8 T cells poised to kill

Blood ◽  
2004 ◽  
Vol 104 (12) ◽  
pp. 3463-3471 ◽  
Author(s):  
Christoph Hess ◽  
Terry K. Means ◽  
Patrick Autissier ◽  
Tonia Woodberry ◽  
Marcus Altfeld ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Chemokine Receptor ◽  
Cd8 T Cells ◽  
Molecular Mechanisms ◽  
Cell Subset ◽  
Cd8 T Cell ◽  
Effector Memory ◽  
Immune System Activation ◽  
Hiv 1

CD8 T cells play a key role in host defense against intracellular pathogens. Efficient migration of these cells into sites of infection is therefore intimately linked to their effector function. The molecular mechanisms that control CD8 T-cell trafficking into sites of infection and inflammation are not well understood, but the chemokine/chemokine receptor system is thought to orchestrate this process. Here we systematically examined the chemokine receptor profile expressed on human CD8 T cells. Surprisingly, we found that CXC chemokine receptor 1 (CXCR1), the predominant neutrophil chemokine receptor, defined a novel interleukin-8/CXC ligand 8 (IL-8/CXCL8)–responsive CD8 T-cell subset that was enriched in perforin, granzyme B, and interferon-γ (IFNγ), and had high cytotoxic potential. CXCR1 expression was down-regulated by antigen stimulation both in vitro and in vivo, suggesting antigen-dependent shaping of the migratory characteristics of CD8 T cells. On virus-specific CD8 T cells from persons with a history of Epstein-Barr virus (EBV) and influenza infection, CXCR1 expression was restricted to terminally differentiated effector memory cells. In HIV-1 infection, CXCR1-expressing HIV-1–specific CD8 T cells were present only in persons who were able to control HIV-1 replication during structured treatment interruptions. Thus, CXCR1 identifies a subset of CD8 T cells poised for immediate cytotoxicity and early recruitment into sites of innate immune system activation.

Sign in / Sign up

Export Citation Format

Share Document