Diagnosis of Partial Retrograde Ejaculation in Non-Azoospermic Infertile Men with Low Semen Volume

Abstract Objective Infertility had an increasing trend between couples in Iran. Several factors such as lifestyle, physical activity, unhealthy dietary habits and stress are associated with production of ROS in seminal fluid. The aim of this study was to identify the role of dietary antioxidants and vitamins intake on semen quality parameters, among Iranian infertile men. Methods This cross-sectional study was performed on 400 newly diagnosed infertile men in Yazd Reproductive sciences Institute from July 2019 to December 2019. The presence of infertility was confirmed by an expert andrologist, based on WHO criteria. Dietary antioxidants and vitamins intake were assessed using a 168 items semi-quantitative food frequency questionnaire (FFQ). Results We found an association between semen volume and Alpha Carotene dietary intake, total motility and Beta Cryptoxanthin dietary intake, and sperm count with riboflavin intake (P = 0.03). Conclusions We concluded that dietary intake of Alpha Carotene, Beta Cryptoxanthin, and Riboflavin are related to sperm count, semen volume and total motility in Iranian infertile men, respectively. Our data suggest that that adhering to a diet that is rich in sources of antioxidant and vitamin can have a positive effect on men’s sexual health. However, more research is needed to confirm these relations and provide the evidence needed to exert these findings into clinical practice.

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Nitric oxide, 8-hydroxydeoxyguanosine, and total antioxidant capacity in human seminal plasma of infertile men and their relationship with sperm parameters

Clinical and Experimental Reproductive Medicine ◽

10.5653/cerm.2020.00423 ◽

2020 ◽

Vol 47 (1) ◽

pp. 54-60

Author(s):

Maryam Gholinezhad ◽

Azadeh Aliarab ◽

Ghasem Abbaszadeh-Goudarzi ◽

Yousefreza Yousefnia-Pasha ◽

Niusha Samadaian ◽

...

Keyword(s):

Nitric Oxide ◽

Male Infertility ◽

Seminal Plasma ◽

Total Antioxidant Capacity ◽

Infertile Men ◽

Sperm Counts ◽

Semen Volume ◽

Total Antioxidant ◽

The Mean ◽

Oxidative Biomarkers

Objective: Oxidative stress plays a key role in the pathogenesis of male infertility. But, the adverse effects of oxidative biomarkers on sperm quality remain unclear. This study aimed to investigate the levels of nitric oxide (NO), 8-hydroxydesoxyguanosine (8-OHdG), and total antioxidant capacity (TAC) oxidative biomarkers in seminal plasma and their relationship with sperm parameters.Methods: A total of 77 volunteers participated in the study, including fertile (n=40) and infertile men (n=37). NO, 8-OHdG, and TAC levels were measured using the ferric reducing ability of plasma, Griess reagent method and an enzyme-linked immunosorbent assay kit, respectively.Results: The mean values of sperm parameters in the infertile group were significantly lower than those in the fertile group (p<0.001). The mean 8-OHdG in the seminal plasma of infertile men was significantly higher (p=0.013) than those of controls, while the mean TAC was significantly lower (p=0.046). There was no significant difference in NO level between the two groups. The elevated seminal 8-OHdG levels were negatively correlated with semen volume, total sperm counts and morphology (p<0.001, p=0.001 and p=0.052, respectively). NO levels were negatively correlated with semen volume, total sperm counts and morphology (p=0.014, p=0.020 and p=0.060, respectively). Positive correlations between TAC and both sperm count and morphology (p=0.043 and p=0.025, respectively) were also found.Conclusion: These results suggested that increased levels of NO and 8-OHdG in seminal plasma could have a negative effect on sperm function by inducing damage to the sperm DNA hence their fertility potentials. Therefore, these biomarkers can be useful in the diagnosis and treatment of male infertility.

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A Comprehensive Guide to Sperm Recovery in Infertile Men with Retrograde Ejaculation

The World Journal of Men s Health ◽

10.5534/wjmh.210069 ◽

2021 ◽

Vol 39 ◽

Author(s):

Sajal Gupta ◽

Rakesh Sharma ◽

Ashok Agarwal ◽

Neel Parekh ◽

Renata Finelli ◽

...

Keyword(s):

Retrograde Ejaculation ◽

Infertile Men ◽

Sperm Recovery

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Effect of Vitamin C, Vitamin E, Zinc, Selenium, and Coenzyme Q10 in Infertile Men with Idiopathic Oligoasthenozoospermia

International Journal of Infertility & Fetal Medicine ◽

10.5005/jp-journals-10016-1147 ◽

2017 ◽

Vol 8 (2) ◽

pp. 45-49 ◽

Cited By ~ 4

Author(s):

Ahmed T Alahmar

Keyword(s):

Vitamin E ◽

Vitamin C ◽

Coenzyme Q10 ◽

Seminal Fluid ◽

Semen Analysis ◽

Sperm Concentration ◽

World Health ◽

Infertile Men ◽

Semen Volume ◽

Health Organization

ABSTRACT Introduction Accumulating evidence suggests that oxidative stress plays an important role in the development of male infertility and recently antioxidants have been tried to treat men with idiopathic infertility. Objective To assess the effect of treatment with vitamin C, vitamin E, zinc, selenium, and coenzyme Q10 on seminal fluid parameters in infertile men with idiopathic oligoasthenozoospermia. Materials and methods A prospective randomized trial was conducted on 32 infertile men with idiopathic oligoasthenozoospmia who received a daily supplement of one caplet containing vitamin C (90 mg/day), vitamin E (15 mg/day), coenzyme Q10 (4 mg/day), selenium (30 µg/day), and zinc (5 mg/day) for 3 months. Semen analysis was performed at baseline and 3 months after treatment using World Health Organization (WHO) 2010 guidelines. Results Significant improvement in sperm concentration was observed after combination therapy (9.13 ± 4.29 vs 11.3 ± 6.05 × 106/mL, p < 0.05). Sperm progressive motility (18.1 ± 8.68 vs 24.6 ± 10.2%, p < 0.01) and total motility (28.4 ± 8.71 vs 34.4 ± 11.7%, p < 0.01) also increased significantly following treatment. No change, however, was observed in semen volume or the proportion of sperms with normal morphology. Conclusion The combination of vitamin C, vitamin E, zinc, selenium, and coenzyme Q10 can significantly improve sperm concentration and motility in infertile men with idiopathic oligoasthenozoospermia, which could be attributed to their synergistic antioxidant action. How to cite this article Alahmar AT. Effect of Vitamin C, Vitamin E, Zinc, Selenium, and Coenzyme Q10 in Infertile Men with Idiopathic Oligoasthenozoospermia. Int J Infertil Fetal Med 2017;8(2):45-49.

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The infertility overcoming in men with retrograde ejaculation and anejaculation

Urologicheskie vedomosti ◽

10.17816/uroved7210-15 ◽

2017 ◽

Vol 7 (2) ◽

pp. 10-15 ◽

Cited By ~ 1

Author(s):

Igor A Korneyev ◽

Ruslan D Zasseev

Keyword(s):

Reproductive Medicine ◽

Diagnosis And Treatment ◽

Retrograde Ejaculation ◽

Single Center ◽

Local Database ◽

Infertile Men ◽

Single Center Study ◽

Center Study

In this descriptive retrospective, single-center study, we analyzed the local database of 82 men treated for infertility due to retrograde ejaculation and anejaculation in the International Centre for Reproductive Medicine. Spermatozoa for IVF/ICSI cycles were retrieved from post-ejaculatory urine and by aspiration biopsies (PESA/TESA). An algorithm for diagnosis and treatment of infertile men with retrograde ejaculation and anejaculation has been suggested. (For citation: Korneyev IA, Zasseev RD. The infertility overcoming in men with retrograde ejaculation and anejaculation. Urologicheskie vedomosti. 2017;7(2):10-15. doi: 10.17816/uroved7210-15).

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Decline in semen quality among infertile men during the past 15 years in Western Algeria (SIDI-BEL-ABBES)

South Asian Journal of Experimental Biology ◽

10.38150/sajeb.6(4).p112-118 ◽

2016 ◽

Vol 6 (4) ◽

pp. 112-118

Author(s):

El-haina Fatima Zohra ◽

Bendahmane Malika

Keyword(s):

Semen Quality ◽

Sperm Count ◽

Linear Regression Analysis ◽

Semen Parameters ◽

Motile Sperm ◽

Infertile Men ◽

Semen Volume ◽

Western Algeria ◽

Study Population ◽

Total Motile Sperm Count

The current study aimed at measuring changes in semen quality and quantity in young healthy sperm of the partner in western Algeria over 15 years. A retrospective analysis of semen parameters over 15 years was carried out using linear regression analysis, at the fertility laboratory in West Algeria. Study population consisted of 188 young partners, aged 25 to 35 years, who donated sperm samples for artificial insemination between 2000 and 2015. Their wives with infertility problems were surveyed using questionnaire about their lifestyles and infertility factors. There were no statistically significant changes in semen concentration and motility during the study period. The mean semen volume increased by 0.1 mL per year (P < 0.0001), with a concomitant mean rise of 5.8 × 106 per year in total motile sperm count. The percentage of sperm normal morphology decreased by a mean of 1% per year during the entire period (P < 0.0001). During these 15 past years, there has been an increase in total motile sperm count, and semen volume where-as, a decline in normal sperm morphology has been noticed that is independ-ent of the age and the duration of abstinence of infertile men.

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Does COVID-19 Worsen the Semen Parameters? Early Results of a Tertiary Healthcare Center

Urologia Internationalis ◽

10.1159/000517276 ◽

2021 ◽

pp. 1-6

Author(s):

Erdem Koç ◽

Buğra Bilge Keseroğlu

Keyword(s):

Semen Parameters ◽

City Hospital ◽

Volume Percentage ◽

Multiple Organs ◽

Infertile Men ◽

Global Pandemic ◽

Early Results ◽

Semen Volume ◽

Before And After ◽

Tertiary Healthcare

Introduction: The coronavirus disease 2019 (COVID-19) is a global pandemic which may affect multiple organs and systems including testes and disrupt the gonadal functions. The current study aimed to evaluate the effect of COVID-19 on the semen parameters and sex-related hormone levels in infertile men. Methods: The study included 21 patients who were evaluated in Ankara City Hospital, Andrology Clinic, for male infertility and have had the diagnosis of COVID-19. All the patients were evaluated in terms of semen parameters. The follicle-stimulating hormone, luteinizing hormone, and testosterone (T) levels were also evaluated in 8 of the patients. The results were presented through 2 dependent group analyses, based on the data of the patients collected before and after the diagnosis of COVID-19. Results: None of the patients needed to be hospitalized at any time through the course of COVID-19. There was a significant decrease in semen volume, percentage of total motility, percentage of progressive motility, and normal sperm morphology after COVID-19 (3 [1–8] vs. 2.5 [1.5–5], p = 0.005; 48.6 ± 22.1 vs. 34.7 ± 20.7, p = 0.001; 35.1 ± 21.7 vs. 21.8 ± 15.9, p < 0.001; 6 [3–24] vs. 5 [3–18], p = 0.015; respectively). There was also a significant decline in T level of the patients after the diagnosis of COVID-19 (350.1 ± 115.5 vs. 289.8 ± 103.3, p = 0.009). Conclusion: COVID-19 may have unfavorable effects on the gonadal functions and may lead to further deterioration of the semen parameters in infertile men, which should be considered through the evaluation for infertility.

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