scholarly journals Impact of frontal white matter hyperintensity on instrumental activities of daily living in elderly women with Alzheimer disease and amnestic mild cognitive impairment

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0172484 ◽  
Author(s):  
Noriko Ogama ◽  
Takashi Sakurai ◽  
Toshiharu Nakai ◽  
Shumpei Niida ◽  
Naoki Saji ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Alzheimer Disease ◽  
Activities Of Daily Living ◽  
Daily Living ◽  
Elderly Women ◽  
Amnestic Mild Cognitive Impairment ◽  
White Matter Hyperintensity ◽  
Frontal White Matter

scholarly journals Frontal White Matter Hyperintensity Is Associated with Verbal Aggressiveness in Elderly Women with Alzheimer Disease and Amnestic Mild Cognitive Impairment

2018 ◽  
Vol 8 (1) ◽  
pp. 138-150 ◽  
Author(s):  
Noriko Ogama ◽  
Takashi Sakurai ◽  
Naoki Saji ◽  
Toshiharu Nakai ◽  
Shumpei Niida ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Alzheimer Disease ◽  
Frontal Lobe ◽  
Brain Atrophy ◽  
Amnestic Mild Cognitive Impairment ◽  
White Matter Hyperintensity ◽  
Verbal Aggressiveness ◽  
The Impact

Background/Aims: Behavioral and psychological symptoms of dementia (BPSD) are exhibited in most patients with Alzheimer disease (AD). Although white matter hyperintensity (WMH) is often observed with AD, the precise role of WMH in BPSD remains unclear. The current study aimed to identify the impact of regional WMH on specific features of BPSD in persons with mild to moderate AD and amnestic mild cognitive impairment (aMCI). Methods: A sample of 256 female outpatients with AD (n = 217) and aMCI (n = 39) were recruited. We assessed BPSD using the Dementia Behavior Disturbance Scale. WMH and brain atrophy were evaluated using an automatic segmentation program. Regional WMH was evaluated as periventricular hyperintensity (PVH) and deep WMH in frontal, temporal, occipital, and parietal lobes. Results: Whole-brain WMH was associated with verbal aggressiveness. In multivariate analysis, PVH in the frontal lobe was independently associated with verbal aggressiveness after adjustment for brain atrophy and clinical confounders. Conclusion: The current results indicated that PVH in the frontal lobe was independently associated with verbal aggressiveness.

Effectiveness and Safety Profile of Ginkgo Biloba Standardized Extract (EGb761®) in Patients with Amnestic Mild Cognitive Impairment

2021 ◽  
Vol 20 ◽  
Author(s):  
Ovidiu Băjenaru ◽  
Gabriel Prada ◽  
Florina Antochi ◽  
Cătălin Jianu ◽  
Cătălina Tudose ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Activities Of Daily Living ◽  
Ginkgo Biloba ◽  
Daily Living ◽  
Cognitive Disorders ◽  
Ginkgo Biloba Extract ◽  
Amnestic Mild Cognitive Impairment ◽  
Minimal Improvement ◽  
Severity Of Depression

Background: Ginkgo biloba is a commonsymptomatic treatment for cognitive impairment, although data on its efficacy are controversial. Objective: The aim of the current study was to evaluate the effectiveness of standardized Ginkgo biloba extract EGb761® (Tanakan®) on the improvements in cognitive functions over 24 months in a local cohort of patients diagnosed with amnestic mild cognitive impairment (aMCI). Methods: This multicentre non-interventional study included 500 eligible patients with aMCI treated with 120 mg/day standardized Ginkgo biloba extract EGb761® (Tanakan®). Patients were evaluated using several scales for assessment of cognition, memory, activities of daily living and depression (MMSE, FAQ, CGI, HAM-D) at baseline and every 6 months thereafter for a 24-month period. The median change in MMSE at the 24-month follow-up was the primary outcome of the study. Results: A statistically significant increase of 2 points in the median MMSE score was obtained. In patients with other concomitant cognitive disorders, the improvement in MMSE was less significant. Tanakan® improved memory impairment (using the delayed recall test) and the ability to accomplish activities of daily living (mean FAQ score, 1.7); it also decreased the severity of depression (mean HAM-D score, 2.4) at the end of the study. More than 80% of the patients showed at least minimal improvement of their condition as assessed by the CGI-Improvement Scale. Conclusions: The administration of EGb761® (Tanakan®) led to a significant improvement of cognitive decline, memory, activities of daily living and depression in subjects with aMCI over 24 months.

P1-403: HIGH FRONTAL WHITE MATTER HYPERINTENSITY BURDEN IN INDIVIDUALS WITH MILD COGNITIVE IMPAIRMENT

2006 ◽  
Vol 14 (7S_Part_8) ◽  
pp. P457-P458
Author(s):  
Swati Rane ◽  
Natalie Koh ◽  
Julia P. Owen ◽  
Thomas J. Grabowski
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
White Matter Hyperintensity ◽  
Frontal White Matter

scholarly journals 541 - MRI-BASED MEASUREMENT OF HIPPOCAMPAL VOLUME IN PATIENTS WITH DEMENTIA

2021 ◽  
Vol 33 (S1) ◽  
pp. 83-84
Author(s):  
Supriya Satapathy ◽  
D. Phani Bhushan ◽  
T. Nageshwar Rao ◽  
M. Satyanarayana
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Activities Of Daily Living ◽  
Vascular Dementia ◽  
Daily Living ◽  
Hippocampal Volume ◽  
Amnestic Mild Cognitive Impairment ◽  
Population Increase

Background:Dementia due to probable Alzheimer’s disease (AD) represents between 60 and 80% of all dementias. The total number of estimated AD cases worldwide by 2030 is 65.7 million and 115.4 million by 2050; this represents a twofold population increase in the next 20 years.Magnetic resonance imaging (MRI) has been the primary tool of interest to link hippocampal volume loss with dementia firmly.MRI-based volumetry has been proposed as a promising biomarker.Hippocampal volumetry is useful in discriminating not only cognitively normal individuals from those with dementia but can also differentiate Mild Cognitive Impairment (MCI) from various types of dementia.Research objective:To measure hippocampal volume in various types of dementia. (MMSE) and Activities of daily living (ADL) in patients with dementia.Method:A cross-sectional study conducted for period of one year among 21 patients with Alzheimer’s, vascular dementia, amnestic mild cognitive impairment and 20 healthy age matched controls. MMSE scale was used to stratify patients on cognitive function impairments. ADL scale to assess functional status of the patient ability to perform activities of daily living independently in diverse settings. Hippocampal volume measured using MRI 1.5 T Philips Ingenia, a coronal T1-weighted FFE (Fast Field Echo) 3D sequence.Results:Total Hippocampal volume was reduced by 35% in Alzheimer’s disease, 27% in vascular dementia and 10% in amnestic mild cognitive impairment, compared with control groupConclusions:Moderate positive correlation between mean total hippocampal volume and MMSE scores in patients with dementia which was statistically significant. (P value= 0.001).

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