scholarly journals Feasibility of fresh frozen human cadavers as a research and training model for endovascular image guided interventions

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0242596
Author(s):  
Marloes M. Jansen ◽  
Constantijn E. V. B. Hazenberg ◽  
Quirina M. B. de Ruiter ◽  
Robbert W. van Hamersvelt ◽  
Ronald L. A. W. Bleys ◽  
...  
Keyword(s):  
Femoral Artery ◽  
Lower Extremities ◽  
Intraluminal Pressure ◽  
Human Cadaver ◽  
Image Guided ◽  
Collateral Arteries ◽  
Fresh Frozen ◽  
Human Cadavers ◽  
Human Cadaver Model ◽  
And Training

Objective To describe the feasibility of a fresh frozen human cadaver model for research and training of endovascular image guided procedures in the aorta and lower extremity. Methods The cadaver model was constructed in fresh frozen human cadaver torsos and lower extremities. Endovascular access was acquired by inserting a sheath in the femoral artery. The arterial segment of the specimen was restricted by ligation of collateral arteries and, in the torsos, clamping of the contralateral femoral artery and balloon occlusion of the supratruncal aorta. Tap water was administered through the sheath to create sufficient intraluminal pressure to manipulate devices and acquire digital subtraction angiography (DSA). Endovascular cannulation tasks of the visceral arteries (torso) or the peripheral arteries (lower extremities) were performed to assess the vascular patency of the model. Feasibility of this model is based on our institute’s experiences throughout the use of six fresh frozen human cadaver torsos and 22 lower extremities. Results Endovascular simulation in the aortic and peripheral vasculature was achieved using this human cadaver model. Acquisition of DSA images was feasible in both the torsos and the lower extremities. Approximately 84 of the 90 target vessels (93.3%) were patent, the remaining six vessels showed signs of calcified steno-occlusive disease. Conclusions Fresh frozen human cadavers provide a feasible simulation model for aortic and peripheral endovascular interventions, and can potentially reduce the need for animal experimentation. This model is suitable for the evaluation of new endovascular devices and techniques or to master endovascular skills.

scholarly journals Assessment of a Human Cadaver Model for Training Emergency Medicine Residents in the Ultrasound Diagnosis of Pneumothorax

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Srikar Adhikari ◽  
Wesley Zeger ◽  
Michael Wadman ◽  
Richard Walker ◽  
Carol Lomneth
Keyword(s):  
Emergency Medicine ◽  
Sensitivity And Specificity ◽  
Medical Center ◽  
Academic Medical Center ◽  
Ultrasound Diagnosis ◽  
Normal Lung ◽  
Human Cadaver ◽  
Academic Medical ◽  
Human Cadavers ◽  
Human Cadaver Model

Objectives. To assess a human cadaver model for training emergency medicine residents in the ultrasound diagnosis of pneumothorax.Methods. Single-blinded observational study using a human cadaveric model at an academic medical center. Three lightly embalmed cadavers were used to create three “normal lungs” and three lungs modeling a “pneumothorax.” The residents were blinded to the side and number of pneumothoraces, as well as to each other’s findings. Each resident performed an ultrasound examination on all six lung models during ventilation of cadavers. They were evaluated on their ability to identify the presence or absence of the sliding-lung sign and seashore sign.Results. A total of 84 ultrasound examinations (42-“normal lung,” 42-“pneumothorax”) were performed. A sliding-lung sign was accurately identified in 39 scans, and the seashore sign was accurately identified in 34 scans. The sensitivity and specificity for the sliding-lung sign were 93% (95% CI, 85–100%) and 90% (95% CI, 81–99%), respectively. The sensitivity and specificity for the seashore sign were 80% (95% CI, 68–92%) and 83% (95% CI, 72–94%), respectively.Conclusions. Lightly embalmed human cadavers may provide an excellent model for mimicking the sonographic appearance of pneumothorax.

Targeting accuracy of transcranial magnetic resonance–guided high-intensity focused ultrasound brain therapy: a fresh cadaver model

2013 ◽  
Vol 118 (5) ◽  
pp. 1046-1052 ◽  
Author(s):  
Dorian Chauvet ◽  
Laurent Marsac ◽  
Mathieu Pernot ◽  
Anne-Laure Boch ◽  
Rémy Guillevin ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Human Cadaver ◽  
Fresh Cadaver ◽  
Array Transducer ◽  
Human Cadavers ◽  
Ct Data ◽  
The Right ◽  
Human Cadaver Model

Object This work aimed at evaluating the accuracy of MR-guided high-intensity focused ultrasound (MRgHIFU) brain therapy in human cadaver heads. Methods Eighteen heads of fresh human cadavers were removed with a dedicated protocol preventing intracerebral air penetration. The MR images allowed determination of the ultrasonic target: a part of the thalamic nucleus ventralis intermedius implicated in essential tremor. Osseous aberrations were corrected with simulation-based time reversal by using CT data from the heads. The ultrasonic session was performed with a 512-element phased-array transducer system operating at 1 MHz under stereotactic conditions with thermometric real-time MR monitoring performed using a 1.5-T imager. Results Dissection, imaging, targeting, and planning have validated the feasibility of this human cadaver model. The average temperature elevation measured by proton resonance frequency shift was 7.9°C ± 3°C. Based on MRI data, the accuracy of MRgHIFU is 0.4 ± 1 mm along the right/left axis, 0.7 ± 1.2 mm along the dorsal/ventral axis, and 0.5 ± 2.4 mm in the rostral/caudal axis. Conclusions Despite its limits (temperature, vascularization), the human cadaver model is effective for studying the accuracy of MRgHIFU brain therapy. With the 1-MHz system investigated here, there is millimetric accuracy.

scholarly journals Polymeric stents for the Eustachian tube: development and human cadaver study

2020 ◽  
Vol 6 (3) ◽  
pp. 213-216
Author(s):  
Kerstin Schümann ◽  
Tamara Wilfling ◽  
Gerrit Paasche ◽  
Robert Schuon ◽  
Thomas Lenarz ◽  
...  
Keyword(s):  
Eustachian Tube ◽  
Chronic Otitis Media ◽  
Cadaver Study ◽  
Human Cadaver ◽  
Tube Function ◽  
Human Cadavers ◽  
Radiopaque Markers ◽  
Cadaver Studies ◽  
Preclinical Safety ◽  
Human Cadaver Study

AbstractImpairment of Eustachian tube function with nonsufficient ventilation of the middle ear is a main cause for chronic otitis media. To provide an effective and safe therapy, the innovative concept of Eustachian tube stenting was established. Biodegradable polymeric stents are developed to restore impaired tube function and dissolve after fulfilling their supportive purpose. To evaluate the applicability of the stents in the Eustachian tube, prototypes in conjunction with corresponding implantation instruments were tested in human cadaver studies. Radiopaque markers and a diaphanoscopic approach were tested as additional features to prove correct positioning of catheter and stent in the tube. In the current study biodegradable polymeric stents were implanted in the Eustachian tube of human cadavers without difficulty. Correct positioning of the stents in the tube was proved by diaphanoscopy during intervention and postoperative tomographic and histological analyses. Once designs are optimized on the basis of cadaver studies, preclinical safety and efficacy studies using animal models will be initiated.

Self-sealing, Large Bore Arterial Punctures: A Counterintuitive New Phenomenon

2002 ◽  
Vol 124 (4) ◽  
pp. 342-346
Author(s):  
Blayne A. Roeder ◽  
Charles F. Babbs ◽  
William E. Schoenlein ◽  
Klod Kokini ◽  
Farshid Sadeghi
Keyword(s):  
Cardiac Catheterization ◽  
Femoral Artery ◽  
Standard Technique ◽  
Needle Insertion ◽  
Catheter Removal ◽  
Intraluminal Pressure ◽  
Modified Technique ◽  
Modeling Studies ◽  
Made In ◽  
Flap Valve

The human femoral artery can bleed dangerously following the removal of a catheter during cardiac catheterization. In this study, a modified technique of needle insertion, simply inserting the needle bevel-down instead of the standard bevel-up approach, was tested as a means to reduce bleeding after catheter removal. Large bore needle punctures were made in surgically exposed arteries of anesthetized pigs using either a standard technique (45 degree approach, bevel up) or a modified technique (25 degree approach, bevel down). For half the punctures, topical phenylephrine solution (1 mg/ml) was applied to the adventitia of the artery to cause constriction. Median bleeding rates were reduced from 81 to less than 1 ml/min/100 mmHg intraluminal pressure by the modified technique with application of phenylephrine. In most cases zero bleeding, that is self-sealing, of the arteries occurred. It is postulated that a flap-valve of tissue created by the modified technique produced this self-sealing behavior. Sophisticated modeling studies are needed to fully understand this new phenomenon.

Gliding characteristics and gap formation for locking and grasping tendon repairs: a biomechanical study in a human cadaver model

2004 ◽  
Vol 29 (1) ◽  
pp. 6-14 ◽  
Author(s):  
Tatsuro Tanaka ◽  
Peter C Amadio ◽  
Chunfeng Zhao ◽  
Mark E Zobitz ◽  
Chao Yang ◽  
...  
Keyword(s):  
Biomechanical Study ◽  
Human Cadaver ◽  
Gap Formation ◽  
Human Cadaver Model
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