Incidence trends of pediatric onset inflammatory bowel disease in the years 2000–2009 in Saxony, Germany–first results of the Saxon Pediatric IBD Registry

Aims In developed countries, the incidence of inflammatory bowel disease (IBD) such as Crohn's disease (CD) and ulcerative colitis (UC) is increasing. Therefore, we aimed to investigate the incidence rates and trends over time in the population of children and adolescents in one of the federal states of Germany, in Saxony. Methods Over the 10-year period 2000–2009 all 31 children’s hospitals and pediatric gastroenterologists, respectively in Saxony reported all IBD patients up to 15 years of age to the Saxon Pediatric IBD Registry. The completeness of the registry was estimated as 96.7% by independent surveys in the years 2005–2009. Incidence rates were presented as age-standardized incidence rates (ASR) regarding New European Standard Population 1990 per 100,000 person-years (PY) with 95% confidence intervals [CI]. Joinpoint and linear regression was used for trend analyses. Results 344 patients with confirmed IBD between 2000–2009 were included in the epidemiological evaluation: 212 (61.6%) patients with CD, 122 (35.6%) with UC and 10 (2.9%) with unclassified IBD (IBD-U). The ASR per 100,000 PY over the whole observation period was 7.2 [6.4–7.9] for IBD, 4.4 [3.8–5.0] for CD, 2.6 [2.1–3.0] for UC and 0.2 [0.1–0.3] for IBD-U. For IBD, the ASR per 100,000 PY increased from 4.6 [2.8–6.3] in 2000 to 10.5 [7.5–13.6] in 2009. The incidence trend analysis of ASRs using the joinpoint regression confirmed a significant increase of IBD as well as UC. The mean age at first diagnosis decreased significantly during the observation period from 11.5 (11.0–13.4) in 2000 to 9.6 (5.1–13.5) years in 2009. The median of the diagnostic latency among IBD patients was 3 months. Conclusion The incidence of IBD in children and adolescents in Saxony was slightly higher than the average of other countries in the same time period and followed the trend towards a general increase of IBD. The age at diagnosis was subject to a very unfavorable downward trend.

Download Full-text

Incidence and Prevalence Trends of Pediatric Inflammatory Bowel Disease in the Daegu-Kyungpook Province From 2017 to 2020

Frontiers in Pediatrics ◽

10.3389/fped.2021.810173 ◽

2022 ◽

Vol 9 ◽

Author(s):

Jae Young Choe ◽

Sujin Choi ◽

Ki Hwan Song ◽

Hyo-Jeong Jang ◽

Kwang-Hae Choi ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Children And Adolescents ◽

Bowel Disease ◽

Population Based ◽

Annual Number ◽

Number Of Children ◽

Pediatric Inflammatory Bowel Disease ◽

Prevalence Trends ◽

Inflammatory Bowel ◽

Pediatric Ibd

Background and Aim: There is paucity of data regarding the epidemiology of pediatric IBD in Asia compared to that of Western countries. We aimed to investigate the incidence and prevalence trends of pediatric inflammatory bowel disease (IBD) in the Daegu-Kyungpook province of South Korea from 2017 to 2020.Methods: This study was a multicenter, retrospective study conducted in eight IBD referral centers located in the Daegu-Kyungpook province. Children and adolescents of ≤18 years who were initially diagnosed with IBD between 2017 and 2020 were included. The annual number of children and adolescents newly diagnosed with IBD and the annual resident population of children and adolescents ≤18 years of age in the Daegu-Kyungpook province were investigated to calculate the annual incidence and prevalence in the region.Results: A total 304 children and adolescents that had been diagnosed with IBD were included in this study. Among these patients, 71.4% had been diagnosed with Crohn's disease (CD), and 28.6% with ulcerative colitis (UC). The population based annual incidences of IBD from 2017 to 2020 were each 7.24, 6.82, 10.27, and 13.33 per 100,000, respectively (P for trend <0.001), 4.48, 5.26, 7.39, and 9.8 per 100,000, respectively, for CD (P for trend <0.001), and 2.76, 1.56, 2.88, and 3.53 per 100,000, respectively, for UC (P for trend = 0.174).Conclusion: Pediatric IBD, especially CD has significantly increased recently in the Daegu-Kyungpook province. Epidemiology studies from other regions of Asia are required to better elucidate this trend of increase in Asia.

Download Full-text

Incidence and Paris Classification of Pediatric Inflammatory Bowel Disease

Gastroenterology Research and Practice ◽

10.1155/2014/904307 ◽

2014 ◽

Vol 2014 ◽

pp. 1-10 ◽

Cited By ~ 21

Author(s):

Katalin Eszter Müller ◽

Peter Laszlo Lakatos ◽

Maria Papp ◽

Gabor Veres

Keyword(s):

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Western Europe ◽

Epidemiological Data ◽

Epidemiological Studies ◽

Incidence Trends ◽

Colonic Involvement ◽

Inflammatory Bowel ◽

Paris Classification ◽

Pediatric Ibd

New epidemiological data suggest that the incidence of inflammatory bowel disease (IBD) is increasing. As a result the burden of disease accounts for more strains to the health care system. The clinical variability queries whether disease characteristics are related to clinical outcome. Our aim was to delineate the latest results of incidence trends in pediatric IBD and to compare the first experiences with Paris Classification. Incidence of pediatric IBD has been increasing in Western Europe and in Eastern Europe. To better characterize IBD, Paris Classification was introduced and validated recently. Ileocolonic involvement is the most characteristic disease location in Crohn’s disease (CD) based on applying Paris Classification. The rate of perianal disease and complicated behaviour in CD was similar. It is of interest that CD patients with colonic involvement were less likely to have stricturing disease compared with patients with ileal involvement. In addition, pancolitis dominated in ulcerative colitis (UC). However, most countries lack prospective, nationwide epidemiological studies to estimate incidence trends. This review emphasizes the importance of nationwide registries that enroll all pediatric IBD cases serving reliable data for “everyday practice.” These first reports have shown that Paris Classification is a useful tool to determine the pediatric IBD phenotype.

Download Full-text

Aerobic Exercise Training in Children and Adolescents with Inflammatory Bowel Disease: Influence on Psychological Functioning, Sleep and Physical Performance

10.26226/morressier.588f064fd462b8028d891fb4 ◽

2017 ◽

Author(s):

Serge Brand

Keyword(s):

Inflammatory Bowel Disease ◽

Exercise Training ◽

Aerobic Exercise ◽

Children And Adolescents ◽

Physical Performance ◽

Bowel Disease ◽

Psychological Functioning ◽

Aerobic Exercise Training ◽

Inflammatory Bowel

Download Full-text

The Economic Impact of Inflammatory Bowel Disease in Canada

Canadian Journal of Gastroenterology ◽

10.1155/2004/354610 ◽

2004 ◽

Vol 18 (4) ◽

pp. 255-257

Author(s):

Robert Hilsden

Keyword(s):

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Labour Force ◽

Incidence Rates ◽

Age Group ◽

Group Level ◽

The Past ◽

Inflammatory Bowel ◽

Using Data ◽

Very High

Longobardi and colleagues examined the effect of inflammatory bowel disease (IBD) on employment, using data from 10,891 respondents aged 20 to 64 years from the 1998 cycle of the Canadian National Population Health Survey (NPHS) (1). This sample included 187 (1.7%) subjects who self-reported IBD or a similar bowel disorder. A significantly greater proportion of IBD than non-IBD respondents reported that they were not in the labour force (28.9% versus 18.5%). Even after adjusting for other factors (age group, level of pain, etc), subjects with IBD had a 2.9% higher nonparticipation rate (21.4%). For example, among people not hospitalized within the past year and with no limitation of activities due to pain, IBD subjects were 1.2 times more likely to be unemployed than those without IBD. Subjects who reported high levels of pain had a very high probability of being out of the labour force. Based on Canadian annual compensation data for all employed persons in Canada, and age- and sex-specific prevalence, and incidence rates for IBD, the authors estimated that there are 119,980 IBD patients between the ages of 20 and 64 years in Canada and that this group includes 3479 people who are not in the labour force. This translates into lost wages of $104.2 million, or $868 per IBD patient

Download Full-text

Family Interaction and Locus of Control in Children and Adolescents with Inflammatory Bowel Disease

Journal of the American Academy of Child & Adolescent Psychiatry ◽

10.1097/00004583-199111000-00008 ◽

1991 ◽

Vol 30 (6) ◽

pp. 913-920 ◽

Cited By ~ 20

Author(s):

INGEMAR ENGSTRÖM

Keyword(s):

Inflammatory Bowel Disease ◽

Locus Of Control ◽

Children And Adolescents ◽

Bowel Disease ◽

Family Interaction ◽

Inflammatory Bowel

Download Full-text

Phenotypic Features and Longterm Outcomes of Pediatric Inflammatory Bowel Disease Patients with Arthritis and Arthralgia

The Journal of Rheumatology ◽

10.3899/jrheum.170168 ◽

2017 ◽

Vol 44 (11) ◽

pp. 1636-1643 ◽

Cited By ~ 2

Author(s):

Osnat Nir ◽

Firas Rinawi ◽

Gil Amarilyo ◽

Liora Harel ◽

Raanan Shamir ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Medical Records ◽

Biologic Therapy ◽

Joint Involvement ◽

Pediatric Inflammatory Bowel Disease ◽

History Of ◽

Inflammatory Bowel ◽

Phenotypic Features ◽

Pediatric Ibd

Objective.The natural history of pediatric inflammatory bowel disease (IBD) patients with joint involvement has not been clearly described. Thus, we aimed to investigate phenotypic features and clinical outcomes of this distinct association.Methods.The medical records of patients with pediatric IBD diagnosed from 2000 to 2016 were reviewed retrospectively. Main outcome measures included time to first flare, hospitalization, surgery, and biologic therapy.Results.Of 301 patients with Crohn disease (median age 14.2 yrs), 37 (12.3%) had arthritis while 44 (14.6%) had arthralgia at diagnosis. Arthritis and arthralgia were more common in women (p = 0.028). Patients with arthritis and arthralgia demonstrated lower rates of perianal disease (2.7% and 4.5% vs 16.9%, p = 0.013), whereas patients with arthritis were more likely to be treated with biologic therapy (HR 2.05, 95% CI 1.27–3.33, p = 0.009). Of 129 patients with ulcerative colitis (UC; median age 13.7 yrs), 3 (2.3%) had arthritis and 16 (12.4%) had arthralgia at diagnosis. Patients with arthralgia were treated more often with corticosteroids (p = 0.03) or immunomodulator therapies (p = 0.003) compared with those without joint involvement. The likelihood to undergo colectomy was significantly higher in patients with arthralgia (HR 2.9, 95% CI 1.1–7.4, p = 0.04). During followup (median 9.0 yrs), 13 patients developed arthritis (3.3%). Arthralgia at diagnosis was a significant predictor for the development of arthritis during followup (HR 9.0, 95% CI 2.86–28.5, p < 0.001).Conclusion.Pediatric IBD patients with arthritis have distinct phenotypic features. Arthralgia at diagnosis is a predictor for colectomy in UC and a risk factor for the development of arthritis during followup.

Download Full-text