scholarly journals Comparison of revised EWGSOP2 criteria of sarcopenia in patients with cancer using different parameters of muscle mass

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0257446
Author(s):  
Ana Paula Trussardi Fayh ◽  
Iasmin Matias de Sousa
Keyword(s):  
Cancer Patients ◽  
Muscle Mass ◽  
Handgrip Strength ◽  
Lumbar Vertebra ◽  
Cross Sectional Study ◽  
Diagnostic Methods ◽  
Cross Sectional ◽  
Kappa Test ◽  
European Working ◽  
Sensitivity Specificity

Calf circumference (CC) has been established as a marker of muscle mass (MM) with good performance for predicting survival in individuals with cancer. The study aims to determine the prevalence of sarcopenia according to the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria and to evaluate the accuracy of sarcopenia using low CC relative to MM assessment by computed tomography (CT) at third lumbar vertebra level (L3) as a reference. Cross-sectional study with cancer patients aged ≥ 60 years. Data included socio-demographic, clinical and anthropometric variables. MM was assessed by CC and by CT images at the L3. Sarcopenia was diagnosed according to the EWGSOP2 criteria: a) low handgrip strength (HGS) + reduced MM evaluated by CT; and b) low HGS + low CC. Pearson’s correlation, accuracy, sensitivity, specificity, positive predictive and negative predictive value were analyzed. A total of 108 patients were evaluated, age of 70.6 ± 7.4 years (mean ± standard deviation). The prevalence of sarcopenia was of 24.1% (low MM) and 25.9% (low CC). The Kappa test showed a substantial agreement (K = 0.704), 81% sensitivity, and 92% specificity. Although the EWGSOP2 advises that we should use CC measures in the algorithm for sarcopenia when no other MM diagnostic methods are available, the findings allow the use of CC instead of MM by CT in cancer patients.

scholarly journals Inflammatory potential of the diet and risk of sarcopenia and its components

2020 ◽  
Author(s):  
Amir Bagheri ◽  
Sanaz Soltani ◽  
Rezvan Hashemi ◽  
Ramin Heshmat ◽  
Ahmadreza Dorosty Motlagh ◽  
...  
Keyword(s):  
Muscle Mass ◽  
Handgrip Strength ◽  
Dietary Assessment ◽  
Large Body ◽  
Population Based ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Cross Sectional ◽  
Abnormal Gait ◽  
European Working

Abstract Background: Despite a large body of evidence on the link between dietary inflammatory index (DII) and several chronic conditions, limited data are available about the association of DII and sarcopenia. This study aimed to examine the relationship between inflammatory potential of the diet (as measured by DII) and sarcopenia and its components among community-dwelling elderly population.Methods: This population-based cross-sectional study was performed in 2011 among 300 elderly people (150 men and 150 women) aged ≥55 years, who were selected using cluster random sampling method. Dietary assessment was done using a pre-tested food frequency questionnaire. Energy-adjusted DII was calculated based on earlier studies. Sarcopenia and its components were determined based on the European Working Group on Sarcopenia (EWGSOP) definition.Results: Mean age of study participants was 66.7 ± 7.7 y. Subjects in the highest tertile of DII score (i.e. those with a more pro-inflammatory diet) were more likely to be older (P=0.02). The prevalence of sarcopenia (P=0.016) and low muscle mass (P=0.041) was significantly higher among subjects in the top tertile compared with those in the bottom tertile of DII. After adjustment for potential confounders, those with the highest DII were 2.18 times (95% CI: 1.01-4.74) more likely to have sarcopenia than those with the lowest DII. With regard to components of sarcopenia, subjects in the top tertile of DII had not significantly greater odds of low muscle mass (OR: 1.38; 95% CI: 0.72-2.63), abnormal handgrip strength (OR: 0.97; 95% CI: 0.49-1.89), and abnormal gait speed (OR: 1.61; 95% CI: 0.84-3.08) than those in the bottom tertile.Conclusions: In conclusion, a diet with more pro-inflammatory potential was associated with a greater odds of sarcopenia. Further studies are required to confirm these findings.

scholarly journals The Relationship Between Food-Based Pro-inflammatory Diet and Sarcopenia: Findings From a Cross-Sectional Study in Iranian Elderly People

2021 ◽  
Vol 8 ◽  
Author(s):  
Amir Bagheri ◽  
Rezvan Hashemi ◽  
Sanaz Soltani ◽  
Ramin Heshmat ◽  
Ahmadreza Dorosty Motlagh ◽  
...  
Keyword(s):  
Muscle Mass ◽  
Gait Speed ◽  
Handgrip Strength ◽  
Binary Logistic Regression ◽  
Cross Sectional Study ◽  
Binary Logistic Regression Analysis ◽  
Dietary Intakes ◽  
Cross Sectional ◽  
European Working ◽  
Significant Difference

Background: Sarcopenia has rarely been linked to Food-based Inflammatory Potential of the Diet (FIPD) in earlier studies. This study was performed to examine the association of FIPD and sarcopenia and its components.Method: In the cross-sectional research, dietary intakes of 300 randomly-selected elderly adults aged 55 years or older were collected through a validated food frequency questionnaire. We constructed FIPD score based on average consumptions of 28 food items. According to The European Working Group on Sarcopenia definition, sarcopenia and its components such as muscle strength, muscle mass, and gait speed were defined.Result: No significant difference was found between the prevalence of sarcopenia (P = 0.05), low muscle mass (P = 0.27), low handgrip strength (P = 0.72), and lower gait speed (P = 0.14) across tertiles of FIPD score. Moreover, we did not find significant differences among means of handgrip strength (P = 0.65), muscle mass (P = 0.33), and walking speed (P = 0.89) across FIPD categories. However, binary logistic regression analysis indicated a significant positive relationship between FIPD score and odds of sarcopenia; such that subjects in the top vs. those in the bottom FIPD tertile had 155% greater chance of having sarcopenia (OR: 2.55; 95% CI: 1.17–5.55). After controlling for all confounding factors, this association strengthened (OR: 2.67; 95% CI: 1.18–6.01).Conclusion: We found that greater FIPD score, which means a more pro-inflammatory diet, was positively linked with sarcopenia.

scholarly journals Inflammatory potential of the diet and risk of sarcopenia and its components

2020 ◽  
Author(s):  
Amir Bagheri ◽  
Sanaz Soltani ◽  
Rezvan Hashemi ◽  
Ramin Heshmat ◽  
Ahmadreza Dorosty Motlagh ◽  
...  
Keyword(s):  
Muscle Mass ◽  
Handgrip Strength ◽  
Dietary Assessment ◽  
Large Body ◽  
Population Based ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Cross Sectional ◽  
Abnormal Gait ◽  
European Working

Abstract Background: Despite a large body of evidence on the link between dietary inflammatory index (DII) and several chronic conditions, limited data are available about the association of DII and sarcopenia. This study aimed to examine the relationship between inflammatory potential of the diet (as measured by DII) and sarcopenia and its components among community-dwelling elderly population.Methods: This population-based cross-sectional study was performed in 2011 among 300 elderly people (150 men and 150 women) aged ≥55 years, who were selected using cluster random sampling method. Dietary assessment was done using a pre-tested food frequency questionnaire. Energy-adjusted DII was calculated based on earlier studies. Sarcopenia and its components were determined based on the European Working Group on Sarcopenia (EWGSOP) definition.Results: Mean age of study participants was 66.7 ± 7.7 y. Subjects in the highest tertile of DII score (i.e. those with a more pro-inflammatory diet) were more likely to be older (P=0.02). The prevalence of sarcopenia (P=0.016) and low muscle mass (P=0.041) was significantly higher among subjects in the top tertile compared with those in the bottom tertile of DII. After adjustment for potential confounders, those with the highest DII were 2.18 times (95% CI: 1.01-4.74) more likely to have sarcopenia than those with the lowest DII. With regard to components of sarcopenia, subjects in the top tertile of DII had not significantly greater odds of low muscle mass (OR: 1.38; 95% CI: 0.72-2.63), abnormal handgrip strength (OR: 0.97; 95% CI: 0.49-1.89), and abnormal gait speed (OR: 1.61; 95% CI: 0.84-3.08) than those in the bottom tertile.Conclusions: In conclusion, a diet with more pro-inflammatory potential was associated with a greater odds of sarcopenia. Further studies are required to confirm these findings.

scholarly journals Inflammatory potential of the diet and risk of sarcopenia and its components

2020 ◽  
Author(s):  
Amir Bagheri ◽  
Sanaz Soltani ◽  
Rezvan Hashemi ◽  
Ramin Heshmat ◽  
Ahmadreza Dorosty Motlagh ◽  
...  
Keyword(s):  
Muscle Mass ◽  
Handgrip Strength ◽  
Dietary Assessment ◽  
Large Body ◽  
Population Based ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Cross Sectional ◽  
Abnormal Gait ◽  
European Working

Abstract Background: Despite a large body of evidence on the link between dietary inflammatory index (DII) and several chronic conditions, limited data are available about the association of DII and sarcopenia. This study aimed to examine the relationship between inflammatory potential of the diet (as measured by DII) and sarcopenia and its components among community-dwelling elderly population.Methods: This population-based cross-sectional study was performed in 2011 among 300 elderly people (150 men and 150 women) aged ≥55 years, who were selected using cluster random sampling method. Dietary assessment was done using a pre-tested food frequency questionnaire. Energy-adjusted DII was calculated based on earlier studies. Sarcopenia and its components were determined based on the European Working Group on Sarcopenia (EWGSOP) definition.Results: Mean age of study participants was 66.7 ± 7.7 y. Subjects in the highest tertile of DII score (i.e. those with a more pro-inflammatory diet) were more likely to be older (P=0.02). The prevalence of sarcopenia (P=0.016) and low muscle mass (P=0.041) was significantly higher among subjects in the top tertile compared with those in the bottom tertile of DII. After adjustment for potential confounders, those with the highest DII were 2.18 times (95% CI: 1.01-4.74) more likely to have sarcopenia than those with the lowest DII. With regard to components of sarcopenia, subjects in the top tertile of DII had not significantly greater odds of low muscle mass (OR: 1.38; 95% CI: 0.72-2.63), abnormal handgrip strength (OR: 0.97; 95% CI: 0.49-1.89), and abnormal gait speed (OR: 1.61; 95% CI: 0.84-3.08) than those in the bottom tertile.Conclusions: In conclusion, a diet with more pro-inflammatory potential was associated with a greater odds of sarcopenia. Further studies are required to confirm these findings.

scholarly journals Inflammatory potential of the diet and risk of sarcopenia and its components

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Amir Bagheri ◽  
Sanaz Soltani ◽  
Rezvan Hashemi ◽  
Ramin Heshmat ◽  
Ahmadreza Dorosty Motlagh ◽  
...  
Keyword(s):  
Muscle Mass ◽  
Handgrip Strength ◽  
Dietary Assessment ◽  
Large Body ◽  
Population Based ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Cross Sectional ◽  
Abnormal Gait ◽  
European Working

Abstract Background Despite a large body of evidence on the link between dietary inflammatory index (DII) and several chronic conditions, limited data are available about the association of DII and sarcopenia. This study aimed to examine the relationship between inflammatory potential of the diet (as measured by DII) and sarcopenia and its components among community-dwelling elderly population. Methods This population-based cross-sectional study was performed in 2011 among 300 elderly people (150 men and 150 women) aged ≥55 years, who were selected using cluster random sampling method. Dietary assessment was done using a pre-tested food frequency questionnaire. Energy-adjusted DII was calculated based on earlier studies. Sarcopenia and its components were determined based on the European Working Group on Sarcopenia (EWGSOP) definition. Results Mean age of study participants was 66.7 ± 7.7 y. Subjects in the highest tertile of DII score (i.e. those with a more pro-inflammatory diet) were more likely to be older (P = 0.02). The prevalence of sarcopenia (P = 0.016) and low muscle mass (P = 0.041) was significantly higher among subjects in the top tertile compared with those in the bottom tertile of DII. After adjustment for potential confounders, those with the highest DII were 2.18 times (95% CI: 1.01–4.74) more likely to have sarcopenia than those with the lowest DII. With regard to components of sarcopenia, subjects in the top tertile of DII had not significantly greater odds of low muscle mass (OR: 1.38; 95% CI: 0.72–2.63), abnormal handgrip strength (OR: 0.97; 95% CI: 0.49–1.89), and abnormal gait speed (OR: 1.61; 95% CI: 0.84–3.08) than those in the bottom tertile. Conclusions In conclusion, a diet with more pro-inflammatory potential was associated with a greater odds of sarcopenia. Further studies are required to confirm these findings.

scholarly journals Inflammatory Potential of the Diet and Risk of Sarcopenia and its Components

2020 ◽  
Author(s):  
Amir Bagheri ◽  
Sanaz Soltani ◽  
Rezvan Hashemi ◽  
Ramin Heshmat ◽  
Ahmadreza Dorosty Motlagh ◽  
...  
Keyword(s):  
Muscle Mass ◽  
Handgrip Strength ◽  
Dietary Assessment ◽  
Population Based ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Cross Sectional ◽  
Inflammatory Index ◽  
Abnormal Gait ◽  
European Working

Abstract Background: Despite huge evidence on the link between dietary inflammatory index (DII) and several chronic conditions, limited data are available about the association of DII and sarcopenia. This study aimed to examine the relationship between inflammatory potential of the diet (as measured by DII) and sarcopenia and its components among community-dwelling elderly population.Methods: This population-based cross-sectional study was performed in 2011 among 300 elderly people (150 men and 150 women) aged ≥55 years, who were selected using cluster random sampling method. Dietary assessment was done using a pre-tested food frequency questionnaire. Energy-adjusted DII was calculated based on earlier studies. Sarcopenia and its components were determined based on the European Working Group on Sarcopenia (EWGSOP) definition.Results: Mean age of study participants was 66.7 ± 7.7 y. Subjects in the highest tertile of DII were more likely to be older (P=0.02). The prevalence of sarcopenia (P=0.016) and abnormal muscle mass (P=0.041) was significantly higher among subjects in the top tertile compared with those in the bottom tertile of DII. After adjustment for potential confounders, those with the highest DII were 2.18 times (95% CI: 1.01-4.74) more likely to have sarcopenia than those with the lowest DII. With regard to components of sarcopenia, subjects in the top tertile of DII had not significantly greater odds of abnormal muscle mass (OR: 1.38; 95% CI: 0.72-2.63), abnormal handgrip strength (OR: 0.97; 95% CI: 0.49-1.89), and abnormal gait speed (OR: 1.61; 95% CI: 0.84-3.08) than those in the bottom tertile.Conclusions: In conclusion, a diet with more pro-inflammatory potential was associated with a greater odd of sarcopenia. Further studies are required to confirm these findings.

scholarly journals Prevalence of Sarcopenia in Community-Dwelling Older Adults in Valencia, Spain

2020 ◽  
Vol 17 (23) ◽  
pp. 9130
Author(s):  
Carlos Guillamón-Escudero ◽  
Angela Diago-Galmés ◽  
Jose M. Tenías-Burillo ◽  
Jose M. Soriano ◽  
Julio J. Fernández-Garrido
Keyword(s):  
Older Adults ◽  
Muscle Mass ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Cross Sectional ◽  
Men And Women ◽  
Sit To Stand ◽  
European Working ◽  
Appendicular Skeletal Muscle ◽  
Different Populations

This study is an observational and cross-sectional study on the prevalence of sarcopenic disease in 202 autonomous older adults; 18.8 and 81.2% were men and women, respectively, living in their own homes in Valencia, Spain. Sarcopenia was diagnosed using the criteria and cutting points for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), using the tests: SARC-F, grip strength, sit-to-stand, gait speed, appendicular skeletal muscle mass and short physical performance battery. According to the EWGSOP2 criteria, probable sarcopenia was present in 21.1% and 18.3% of men and women, respectively, and the sum of confirmed and severe sarcopenia was 7.9% and 7.3% in men and in women, respectively. A relationship was shown between the prevalence of the disease and the age of the participants, but no significant differences were found between the sum of confirmed and severe sarcopenia between the sexes, nor a relationship between the amount of muscle mass and the strength of grip. The SARC-F questionnaire diagnosed 40% of the sarcopenia cases present in the study. More thorough research is needed to continue using the EWGSOP2 criteria in different populations to establish a correct prevalence of sarcopenic disease in different populations of the world.

scholarly journals The prevalence of CT-defined low skeletal muscle mass in patients with metastatic cancer: a cross-sectional multicenter French study (the SCAN study)

2021 ◽  
Author(s):  
Bruno Raynard ◽  
Frederic Pigneur ◽  
Mario Di Palma ◽  
Elise Deluche ◽  
François Goldwasser
Keyword(s):  
Skeletal Muscle ◽  
Cancer Patients ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Metastatic Cancer ◽  
Lumbar Vertebrae ◽  
Diagnostic Methods ◽  
Routine Practice ◽  
Nutritional Management ◽  
Cross Sectional

Abstract Background Cachexia, characterized by involuntary muscle mass loss, negatively impacts survival outcomes, treatment tolerability, and functionality in cancer patients. However, there is a limited appreciation of the true prevalence of low muscle mass due to inconsistent diagnostic methods and limited oncologist awareness. Methods Twenty-nine French healthcare establishments participated in this cross-sectional study, recruiting patients with those metastatic cancers most frequently encountered in routine practice (colon, breast, kidney, lung, prostate). The primary outcome was low skeletal muscle mass prevalence, as diagnosed by estimating the skeletal mass index (SMI) in the middle of the third-lumbar vertebrae (L3) level via computed tomography (CT). Other objectives included an evaluation of nutritional management, physical activity, and toxicities related to ongoing treatment. Results Seven hundred sixty-six patients (49.9% males) were enrolled with a mean age of 65.0 years. Low muscle mass prevalence was 69.1%. Only one-third of patients with low skeletal muscle mass were receiving nutritional counselling and only 28.4% were under nutritional management (oral supplements, enteral or parenteral nutrition). Physicians highly underdiagnosed those patients identified with low skeletal muscle mass, as defined by the primary objective, by 74.3% and 44.9% in obese and non-obese patients, respectively. Multivariate analyses revealed a lower risk of low skeletal muscle mass for females (OR: 0.22, P < 0.01) and those without brain metastasis (OR: 0.34, P < 0.01). Low skeletal muscle mass patients were more likely to have delayed treatment administration due to toxicity (11.9% versus 6.8%, P = 0.04). Conclusions There is a critical need to raise awareness of low skeletal muscle mass diagnosis among oncologists, and for improvements in nutritional management and physical therapies of cancer patients to curb potential cachexia. This calls for cross-disciplinary collaborations among oncologists, nutritionists, physiotherapists, and radiologists.

scholarly journals Association Between Platelet, White Blood Cell Count, Platelet To White Blood Cell Ratio and Sarcopenia in Community-Dwelling Older Adults: Focus On Bushehr Elderly Health (BEH) Program

2021 ◽  
Author(s):  
Mohamad Gholizade ◽  
Akram Farhadi ◽  
Maryam Marzban ◽  
Mehdi Mahmudpour ◽  
Iraj Nabipour ◽  
...  
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Handgrip Strength ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
P Value ◽  
Cross Sectional ◽  
Age Related ◽  
European Working ◽  
Elderly Health

Abstract Background Sarcopenia is a progressive age-related skeletal muscle disorder associated with harmful impacts on health. The present study aimed to investigate the relation between sarcopenia, platelet (PLT), white blood cell (WBC), and PLT to WBC ratio (PWR) due to the importance of early sarcopenia diagnosis. Methods This cross-sectional study was conducted based on the second stage of the Bushehr Elderly Health (BEH) Program. Sarcopenia was defined based on the revised edition of the European Working Group on Sarcopenia in Older People (EWGSOP2) in accordance with the Iranian cut-off point. Univariate and adjusted multivariate logistic regression and linear regression were used to evaluate the associations. Results The prevalence of sarcopenia among participants was 35.73 %. PLT count and PWR were statistically higher in severe sarcopenic participants, while no differences were seen in WBC. In crude analysis, sarcopenia was not associated with quartiles of PLT, WBC, and PWR, while after adjusting for age, marital status, and sex, the association was seen in the fourth quartile of PLT and PWR [OR (95%CI) = 1.40 (1.08 to 1.81), p-value = 0.009 for PLT; OR (95%CI) = 1.55 (1.20 to 2.00), p-value = 0.001 for PWR]. This association remained significant in the fully adjusted model [OR (95%CI) = 1.92 (1.25 to 2.95), p-value = 0.003 for PLT; OR (95%CI) = 1.64 (1.06 to 2.52), p-value = 0.024 for PWR]. Among sarcopenia parameters, PLT count was more likely to be associated with handgrip strength and muscle mass. After stratifying the participants by gender, sarcopenia parameters were no longer statistically significant in men. Conclusion This study showed that PLT and PWR were associated with sarcopenia after considering confounding factors, while this association was not seen in WBC. Moreover, results showed that gender had an important impact on sarcopenia parameters.

scholarly journals Supplementation of Protein at Breakfast Rather Than at Dinner and Lunch Is Effective on Skeletal Muscle Mass in Older Adults

2021 ◽  
Vol 8 ◽  
Author(s):  
Hyeon-Ki Kim ◽  
Hanako Chijiki ◽  
Mayuko Fukazawa ◽  
Jin Okubo ◽  
Mamiho Ozaki ◽  
...  
Keyword(s):  
Muscle Mass ◽  
Protein Intake ◽  
Skeletal Muscle Mass ◽  
Milk Protein ◽  
Intervention Study ◽  
Handgrip Strength ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Related Factors ◽  
Cross Sectional

Background: The effects of different intake patterns of meal protein on muscle mass have not been clarified. We cross-sectionally and longitudinally examined the effect of different timing of protein intake on sarcopenia-related factors in older adults.Methods: This cross-sectional study 1 included 219 (male, n = 69, female, n = 150) elderly subjects aged ≥65 years. Subjects who consumed more protein at breakfast than at dinner were grouped into the morning group (MG, n = 76; male, n = 26; female, n = 50), and those who consumed more protein at dinner than at breakfast were grouped into the evening group (EG, n = 143; male, n = 43; female, n = 100). In cross-sectional study 2-1 (female, n = 125), the subjects were classified into four groups according to the number of meals with sufficient protein intake. In cross-sectional studies 2-2 (female, n = 125) and 2-3 (female, n = 27), the subjects were classified into eight groups and three groups according to whether they had consumed sufficient protein at three meals; sarcopenia-related factors were compared. The intervention study was a placebo-controlled, double-blind, randomized controlled trial that included 40 elderly women with low daily breakfast protein intake. The subjects were divided into four groups: morning protein and placebo intake groups and evening protein and placebo intake groups. Each group consumed the test food (containing 10 g milk protein) or placebo in the morning or evening for 12 weeks. Blood indices and physical function were assessed before and after the intervention.Results: Comparing all subjects, MG showed significantly higher handgrip strength than did EG (P &lt; 0.05). The higher ratio of morning protein intake relative to the total protein intake, the better the muscle mass (r = 0.452, P &lt; 0.05) and handgrip strength (r = 0.383, P &lt; 0.05). The intervention study showed an increase in muscle mass with the intake of milk protein in the morning rather than in the evening (P &lt; 0.05).Conclusions: Protein intake at breakfast might have relatively stronger effects on skeletal muscle mass than at lunch and dinner.

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