scholarly journals Exposure to organochlorine pesticides as a predictor to breast cancer: A case-control study among Ethiopian women

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0257704
Author(s):  
Seblework Mekonen ◽  
Mohammedgezali Ibrahim ◽  
Higemengist Astatkie ◽  
Aynalem Abreha
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cancer Patients ◽  
Organochlorine Pesticides ◽  
Case Control Study ◽  
Case Control ◽  
Breast Cancer Patients ◽  
Study Results ◽  
Study Participants ◽  
Control Study

Breast cancer (BC) is becoming one of the most prevalent non-infectious disease in low and middle income countries. The steady rise of BC incidence may be related to the different risk factors. Among many, rampant presence of environmental pollutants might be one of the risk factors. Therefore, the aim of this study is to investigate exposure to organochlorine pesticides as a risk factor to breast cancer. A case-control study design was employed among breast cancer patients and non-breast cancer individuals (controls). Blood samples were collected from 100 study participants (50 cases and 50 controls) followed by serum separation, extraction and cleanup using standard analytical procdures. The findings revealed that ten organochlorine pesticides were detected in the serum of the study participants. From the detected organochlorine pesticides, heptachlor was observed at higher concentration for breast cancer patients (6.90±4.37 μg/L) and controls (9.15±3.84 μg/L). Mean serum level of p,p’-DDE, p,p’-DDT, heptachlor, gamma-chlordane, endosulfan, and dibutyl-chlorendate were significantly higher in the serum of breast cancer patients than the controls. From the studied pesticides, p,p’-DDT and gamma-chlordane are significant predictors for BC, while, others are equivocal. A unit increment of the concentration of p,p’-DDT (AOR; 2.03, 95% CI: 1.041–3.969) increased the odds of developing breast cancer by two, while for gamma-chlordane (AOR;3.12, 95% CI; 1.186–8.203) by three. Our study results suggesting that, organochlorines are a risk factors for breast cancer in Ethiopia. Decreasing exposure to such organochlorines might have a significant public health relevance in reducing non-communicable chronic illnesses. Besides, continues monitoring of persistent organic pollutants using body biomarkers is important for disease prevention and device mitigation measures.

scholarly journals Organochlorine pesticides accumulation and breast cancer: A hospital-based case–control study

Tumor Biology ◽  
2017 ◽  
Vol 39 (5) ◽  
pp. 101042831769911 ◽  
Author(s):  
Ting-Ting He ◽  
An-Jun Zuo ◽  
Ji-Gang Wang ◽  
Peng Zhao
Keyword(s):  
Breast Cancer ◽  
Logistic Regression ◽  
Polychlorinated Biphenyls ◽  
Cancer Patients ◽  
Organochlorine Pesticides ◽  
Case Control Study ◽  
Case Control ◽  
Breast Cancer Patients ◽  
High Accumulation ◽  
Control Study

The aim of this study is to detect the accumulation status of organochlorine pesticides in breast cancer patients and to explore the relationship between organochlorine pesticides contamination and breast cancer development. We conducted a hospital-based case–control study in 56 patients with breast cancer and 46 patients with benign breast disease. We detected the accumulation level of several organochlorine pesticides products (β-hexachlorocyclohexane, γ-hexachlorocyclohexane, polychlorinated biphenyls-28, polychlorinated biphenyls-52, pentachlorothioanisole, and pp′-dichlorodiphenyldichloroethane) in breast adipose tissues of all 102 patients using gas chromatography. Thereafter, we examined the expression status of estrogen receptor, progesterone receptor, human epidermal growth factor receptor-2 (HER2), and Ki-67 in 56 breast cancer cases by immunohistochemistry. In addition, we analyzed the risk of breast cancer in those patients with organochlorine pesticides contamination using a logistic regression model. Our data showed that breast cancer patients suffered high accumulation levels of pp′-dichlorodiphenyldichloroethane and polychlorinated biphenyls-52. However, the concentrations of pp′-dichlorodiphenyldichloroethane and polychlorinated biphenyls-52 were not related to clinicopathologic parameters of breast cancer. Further logistic regression analysis showed polychlorinated biphenyls-52 and pp′-dichlorodiphenyldichloroethane were risk factors for breast cancer. Our results provide new evidence on etiology of breast cancer.

A Case-Control Study on Risk Factors for Local Recurrences or Distant Metastases in Breast Cancer Patients Treated with Breast-Conserving Surgery

Oncology ◽  
1997 ◽  
Vol 54 (6) ◽  
pp. 468-474 ◽  
Author(s):  
Shinzaburo Noguchi ◽  
Hiroki Koyama ◽  
Tsutomu Kasugai ◽  
Hideaki Tsukuma ◽  
Naoko Tsuji ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cancer Patients ◽  
Case Control Study ◽  
Distant Metastases ◽  
Breast Conserving Surgery ◽  
Case Control ◽  
Breast Cancer Patients ◽  
Local Recurrences ◽  
Control Study

scholarly journals Development of CNS metastases in breast cancer patients treated with curative intent: a case–control study

CNS Oncology ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. CNS61
Author(s):  
Katherine Chakrabarti ◽  
Leigh K Swartz ◽  
Anoop Gill ◽  
Fang Fang ◽  
Kelley M Kidwell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cancer Patients ◽  
Case Control Study ◽  
Case Control ◽  
Lymph Node Status ◽  
Breast Cancer Patients ◽  
Cns Metastases ◽  
Curative Intent ◽  
Control Study

Background: The aim of this study was to identify risk factors that may predispose breast cancer patients to the development of CNS metastases. Materials & methods: We conducted a matched case–control study of breast cancer patients treated with surgery with curative intent. A total of 71 cases and 71 controls were analyzed, matched by year of surgery. Results: In our multivariable model, positive lymph node status (odds ratio [OR]: 5.08; CI: 2.04–12.65), the use of neoadjuvant chemotherapy (OR: 6.02; CI: 2.06–17.57) and triple-negative breast cancer (OR: 5.44; CI: 1.99–14.90) were statistically significant predictors of the development of CNS metastases. Conclusion: Women with certain risk factors have an increased odds of developing CNS metastases and evaluation of utility in brain metastases screening should be considered.

scholarly journals The Efficacy of Pegylated Liposomal Doxorubicin-Based Neoadjuvant Chemotherapy in Breast Cancer: A Retrospective Case-Control Study in Taiwan

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Chih-Chiang Hung ◽  
Youngsen Yang ◽  
I-Chen Tsai ◽  
Chiann-yi Hsu ◽  
Chia-Hua Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Cancer Patients ◽  
Liposomal Doxorubicin ◽  
Case Control Study ◽  
Pegylated Liposomal Doxorubicin ◽  
Case Control ◽  
Breast Cancer Patients ◽  
Study Results ◽  
Control Study

Breast cancer is a global issue regarding women’s health, and high incident rates remain in the Taiwanese female population. Chemotherapy, using anthracycline-based chemotherapeutic agents in neoadjuvant settings, has been introduced as a promising new therapeutic option for treatment of invasive breast cancer. Set apart from conventional anthracycline regimens such as epirubicin, pegylated liposomal doxorubicin (Lipo-Dox®, PLD) was introduced for providing a justifiable treatment effect, while offering a favorable toxicity profile for breast cancer patients in a metastatic setting. However, the efficacy of PLD in neoadjuvant settings for breast cancer patients has not yet been sufficiently reported. This study aims to investigate the efficacy of PLD-based neoadjuvant chemotherapy in breast cancer patients using a retrospective matched case-control study. A total of 183 PLD cases and 183 epirubicin-based controls were included after a 1 : 1 ratio case-control matching procedure was held, according to the matching criteria. These criteria included the patient’s preoperative clinical stage, molecular subtype, chemotherapy regimen with taxanes prior to surgery, and histological grade. All data were collected according to an institutional review board approved protocol. The study results reported that the PLD and epirubicin groups both obtained similar outcomes in pathologic complete response (pCR), recurrence, and overall survival rate with no statistically significant differences. Overall, the study results demonstrate that PLD-based neoadjuvant chemotherapy offers a similar effect of treatment with a favorable toxicity profile within the study follow-up duration, when compared with conventional epirubicin-based neoadjuvant chemotherapy.

A case-control study to identify molecular risk factors for local recurrence in young breast cancer patients

2021 ◽  
Vol 156 ◽  
pp. 127-135
Author(s):  
Sophie C.J. Bosma ◽  
Marlous Hoogstraat ◽  
Erik van Werkhoven ◽  
Michiel de Maaker ◽  
Femke van der Leij ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Local Recurrence ◽  
Cancer Patients ◽  
Case Control Study ◽  
Case Control ◽  
Breast Cancer Patients ◽  
Young Breast Cancer ◽  
Control Study
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