scholarly journals Correction: Seroprevalence of Zika virus in pregnant women from central Thailand

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261598
Author(s):  
Chayawat Phatihattakorn ◽  
Artit Wongsa ◽  
Kirakorn Pongpan ◽  
Sanitra Anuwutnavin ◽  
Sakita Moungmaithong ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Zika Virus ◽  
Central Thailand

scholarly journals Seroprevalence of Zika virus in pregnant women from central Thailand

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0257205
Author(s):  
Chayawat Phatihattakorn ◽  
Artit Wongsa ◽  
Kirakorn Pongpan ◽  
Sanitra Anuwuthinawin ◽  
Sakita Mungmanthong ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Zika Virus ◽  
Neutralizing Antibodies ◽  
Neutralizing Antibody ◽  
First Trimester ◽  
Effective Prevention ◽  
Denv Serotypes ◽  
Siriraj Hospital ◽  
Health Care Monitoring ◽  
Central Thailand

Zika virus (ZKV) infection in a pregnant woman, especially during the first trimester, often results in congenital anomalies. However, the pathogenic mechanism is unknown and one-third of ZKV infected pregnancies are asymptomatic. Neutralizing antibodies against ZKV has been reported in 70% of Thai adults, but the prevalence among pregnant women is unknown. Currently, vaccines and specific treatments for ZKV are under development. A better understanding of the immune status of pregnant women will increase the success of effective prevention guidelines. The prevalence of ZKV infection in pregnant women in antenatal care clinics was investigated during the rainy season from May to October 2019 at Siriraj Hospital, Bangkok, Thailand. We recruited 650 pregnant women (39.42% first, 52.26% second and 7.36% third trimester) and found that 30.77% had ZKV-specific IgG, and 39.81% had neutralizing antibodies (nAb) against ZKV (titer ≥10). Specific and neutralizing antibody levels varied by maternal age, trimester, and month. We further characterized the cross-reaction between ZKV and the four Dengue virus (DENV) serotypes by focused reduction neutralization test (FRNT) and found that cross-reactions were common. In conclusion, about 60% of pregnant women who living in central Thailand may be at risk of ZKV infection due to the absence of neutralizing antibodies against ZKV. The functions of cross-reactive antibodies between related viral genotypes require further study. These findings have implications for health care monitoring in pregnant women including determining the risk of ZKV infection, assisting the development of a flavivirus vaccine, and informing the development of preventative health policies.

scholarly journals Defining Zika virus infection in pregnant women

2019 ◽  
Vol 113 (7) ◽  
pp. 290-290
Author(s):  
Carlo Ticconi ◽  
Giovanni Rezza
Keyword(s):  
Virus Infection ◽  
Pregnant Women ◽  
Zika Virus ◽  
Zika Virus Infection

Socioeconomic Disparities in Knowledge and Behaviors of Zika virus in Pregnant Women [6J]

2018 ◽  
Vol 131 ◽  
pp. 109S-110S ◽  
Author(s):  
Neeraja Chandrasekaran ◽  
Mabel Marotta ◽  
Sabrina Taldone ◽  
Vivek Singh ◽  
Tulay Koru-Sengul ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Zika Virus ◽  
Socioeconomic Disparities ◽  
And Behaviors

scholarly journals Atovaquone Inhibits Arbovirus Replication through the Depletion of Intracellular Nucleotides

2019 ◽  
Vol 93 (11) ◽  
Author(s):  
Angelica Cifuentes Kottkamp ◽  
Elfie De Jesus ◽  
Rebecca Grande ◽  
Julia A. Brown ◽  
Adam R. Jacobs ◽  
...  
Keyword(s):  
Viral Replication ◽  
Pregnant Women ◽  
Vulnerable Populations ◽  
Zika Virus ◽  
Ex Vivo ◽  
Pyrimidine Biosynthesis ◽  
Zikv Infection ◽  
Antiviral Therapies ◽  
Virion Production ◽  
Women And Children

ABSTRACT Arthropod-borne viruses represent a significant public health threat worldwide, yet there are few antiviral therapies or prophylaxes targeting these pathogens. In particular, the development of novel antivirals for high-risk populations such as pregnant women is essential to prevent devastating disease such as that which was experienced with the recent outbreak of Zika virus (ZIKV) in the Americas. One potential avenue to identify new and pregnancy-acceptable antiviral compounds is to repurpose well-known and widely used FDA-approved drugs. In this study, we addressed the antiviral role of atovaquone, an FDA Pregnancy Category C drug and pyrimidine biosynthesis inhibitor used for the prevention and treatment of parasitic infections. We found that atovaquone was able to inhibit ZIKV and chikungunya virus virion production in human cells and that this antiviral effect occurred early during infection at the initial steps of viral RNA replication. Moreover, we were able to complement viral replication and virion production with the addition of exogenous pyrimidine nucleosides, indicating that atovaquone functions through the inhibition of the pyrimidine biosynthesis pathway to inhibit viral replication. Finally, using an ex vivo human placental tissue model, we found that atovaquone could limit ZIKV infection in a dose-dependent manner, providing evidence that atovaquone may function as an antiviral in humans. Taken together, these studies suggest that atovaquone could be a broad-spectrum antiviral drug and a potential attractive candidate for the prophylaxis or treatment of arbovirus infection in vulnerable populations, such as pregnant women and children. IMPORTANCE The ability to protect vulnerable populations such as pregnant women and children from Zika virus and other arbovirus infections is essential to preventing the devastating complications induced by these viruses. One class of antiviral therapies may lie in known pregnancy-acceptable drugs that have the potential to mitigate arbovirus infections and disease, yet this has not been explored in detail. In this study, we show that the common antiparasitic drug atovaquone inhibits arbovirus replication through intracellular nucleotide depletion and can impair ZIKV infection in an ex vivo human placental explant model. Our study provides a novel function for atovaquone and highlights that the rediscovery of pregnancy-acceptable drugs with potential antiviral effects can be the key to better addressing the immediate need for treating viral infections and preventing potential birth complications and future disease.

scholarly journals The Paradigm of the Paradox: Women, Pregnant Women, and the Unequal Burdens of the Zika Virus Pandemic

2016 ◽  
Vol 16 (5) ◽  
pp. 1-4 ◽  
Author(s):  
Lisa H. Harris ◽  
Neil S. Silverman ◽  
Mary Faith Marshall
Keyword(s):  
Pregnant Women ◽  
Zika Virus

Zika virus outbreaks and treatment in pregnant women in Ho Chi Minh City, Vietnam

2018 ◽  
Vol 141 (3) ◽  
pp. 390-391 ◽  
Author(s):  
Thuong C. Bui ◽  
Xuan V. Huynh ◽  
Hoang Nguyen ◽  
KieuTho T. Nguyen ◽  
Chuong D. Nguyen ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Zika Virus ◽  
Ho Chi Minh City

scholarly journals 694: Middle cerebral artery Dopplers and adverse neonatal outcomes among pregnant women with Zika virus infection

2020 ◽  
Vol 222 (1) ◽  
pp. S439
Author(s):  
Thalia Wong ◽  
Jose Paulo Pereira ◽  
Nasim Sobhani ◽  
Renan Fonseca Cardozo ◽  
Helena Abreu Valle ◽  
...  
Keyword(s):  
Virus Infection ◽  
Pregnant Women ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Zika Virus ◽  
Neonatal Outcomes ◽  
Zika Virus Infection ◽  
Adverse Neonatal Outcomes

scholarly journals Personal protective measures of pregnant women against Zika virus infection

2019 ◽  
Vol 53 ◽  
pp. 72
Author(s):  
Vladimir Antonio Dantas Melo ◽  
José Rodrigo Santos Silva ◽  
Roseli La Corte
Keyword(s):  
Pregnant Women ◽  
Urban Area ◽  
Zika Virus ◽  
Rural Areas ◽  
Education Level ◽  
Ministry Of Health ◽  
Chi Square ◽  
Protective Measures ◽  
Exact Test ◽  
Mosquito Nets

OBJECTIVE: To evaluate the adherence of pregnant women to personal protective measures against mosquito bites, recommended by the Ministry of Health, and to investigate the factors associated with the non-adoption of these measures. METHODS: We interviewed 177 pregnant women between November 2016 and February 2017 in the 10 basic health units of the municipality of Propriá, state of Sergipe, two located in the rural area and eight in the urban area, during prenatal appointments, to raise information about the use of preventive measures against the vector transmission of Zika virus. Data were analyzed using descriptive statistical methods, chi-square test or Fisher’s exact test, and the odds ratio was calculated. The independent variables were grouped by the analysis of principal components, and the dependents (the use of repellent, mosquito nets, garments, screens and insecticides) were analyzed using the logistic regression method. RESULTS: Among the measures recommended by the Ministry of Health, mosquito nets were the most used by pregnant women living in rural areas and with low education level, while the repellents were more used by women in the urban area and with higher education level. Women in a vulnerable socio-economic situation presented a risk 2.4 times higher for not using screens in their homes, 1.9 times higher for not changing clothes and 2.5 times higher for not using repellent than pregnant women in better economic conditions. CONCLUSIONS: The socioeconomic status of pregnant women, especially among the less privileged, influenced the use of protective measures against Zika virus, from the purchase of repellent, clothing, insecticides to other resources in the municipality of Propriá, SE.

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