scholarly journals Utility of Serum Fatty Acid Concentrations as a Marker for Acute Myocardial Infarction and Their Potential Role in the Formation of Ischemia-Modified Albumin: A Pilot Study

2009 ◽  
Vol 55 (8) ◽  
pp. 1588-1590 ◽  
Author(s):  
Nadhipuram V Bhagavan ◽  
Ji-Sook Ha ◽  
Joo-Ho Park ◽  
Stacey A Honda ◽  
Carlos N Rios ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Fatty Acid ◽  
Pilot Study ◽  
Potential Role ◽  
Serum Fatty Acid ◽  
Ischemia Modified Albumin

Early increase in serum fatty acid binding protein 4 levels in patients with acute myocardial infarction

2016 ◽  
Vol 7 (6) ◽  
pp. 561-569 ◽  
Author(s):  
Masaru Obokata ◽  
Tatsuya Iso ◽  
Yoshiaki Ohyama ◽  
Hiroaki Sunaga ◽  
Tomoka Kawaguchi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Troponin T ◽  
Binding Protein ◽  
Serum Fatty Acid ◽  
Metabolic Complications ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Background: Acute myocardial infarction (AMI) induces marked activation of the sympathetic nervous system. Fatty acid binding protein 4 (FABP4) is not only an intracellular protein, but also a secreted adipokine that contributes to obesity-related metabolic complications. Here, we examined the role of serum FABP4 as a pathophysiological marker in patients with AMI. Methods and results: We studied 106 patients presenting to the emergency unit with a final diagnosis of AMI, including 12 patients resuscitated from out-of-hospital cardiac arrest (OHCA) caused by ventricular fibrillation. FABP4 levels peaked on admission or just after percutaneous coronary intervention and declined thereafter. Regression analysis revealed no significant correlation between peak FABP4 and peak cardiac troponin T determined by Roche high-sensitive assays (hs-TnT). Notably, FABP4 levels were particularly elevated in AMI patients who were resuscitated from OHCA (median 130.2 ng/mL, interquartile range (IQR) 51.8–243.9 ng/mL) compared with those without OHCA (median 26.1 ng/ml, IQR 17.1–43.4 ng/mL), while hs-TnT levels on admission were not associated with OHCA. Immunohistochemistry of the human heart revealed that FABP4 is abundantly present in adipocytes within myocardial tissue and epicardial adipose tissue. An in vitro study using cultured adipocytes showed that FABP4 is released through a β3-adrenergic receptor (AR)-mediated mechanism. Conclusions: FABP4 levels were significantly elevated during the early hours after the onset of AMI and were robustly increased in OHCA survivors. Together with the finding that FABP4 is released from adipocytes via β3-AR-mediated lipolysis, our data provide a novel hypothesis that serum FABP4 may represent the adrenergic overdrive that accompanies acute cardiovascular disease, including AMI.

scholarly journals Serum Fatty Acids, Traditional Risk Factors, and Comorbidity as Related to Myocardial Injury in an Elderly Population with Acute Myocardial Infarction

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Kristian Laake ◽  
Ingebjørg Seljeflot ◽  
Erik B. Schmidt ◽  
Peder Myhre ◽  
Arnljot Tveit ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Atrial Fibrillation ◽  
Acute Myocardial Infarction ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Elderly Population ◽  
Serum Fatty Acid ◽  
History Of ◽  
Traditional Risk Factors

Background.Epidemiological and randomized clinical trials indicate that marine polyunsaturated n-3 fatty acids (n-3 PUFAs) may have cardioprotective effects.Aim.Evaluate the associations between serum fatty acid profile, traditional risk factors, the presence of cardiovascular diseases (CVD), and peak Troponin T (TnT) levels in elderly patients with an acute myocardial infarction (AMI).Materials and Methods.Patients (n=299) consecutively included in the ongoing Omega-3 fatty acids in elderly patients with myocardial infarction (OMEMI) trial were investigated. Peak TnT was registered during the hospital stay. Serum fatty acid analysis was performed 2–8 weeks later.Results.No significant correlations between peak TnT levels and any of the n-3 PUFAs were observed. However, patients with a history of atrial fibrillation had significantly lower docosahexaenoic acid levels than patients without. Significantly lower peak TnT levels were observed in patients with a history of hyperlipidemia, angina, MI, atrial fibrillation, intermittent claudication, and previous revascularization (allp<0.02).Conclusions.In an elderly population with AMI, no association between individual serum fatty acids and estimated myocardial infarct size could be demonstrated. However, a history of hyperlipidemia and the presence of CVD were associated with lower peak TnT levels, possibly because of treatment with cardioprotective medications.

Serum and urinary human heart fatty acid-binding protein in acute myocardial infarction

1991 ◽  
Vol 24 (2) ◽  
pp. 195-201 ◽  
Author(s):  
Takao Tanaka ◽  
Yuzo Hirota ◽  
Koh-Ichi Sohmiya ◽  
Sinzo Nishimura ◽  
Keishiro Kawamura
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Fatty Acid ◽  
Human Heart ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Fatty acid-binding protein and the early detection of acute myocardial infarction

1998 ◽  
Vol 272 (1) ◽  
pp. 87-92 ◽  
Author(s):  
Jan F.C Glatz ◽  
Ger J van der Vusse ◽  
Maarten L Simoons ◽  
Johannes A Kragten ◽  
M.P van Dieijen-Visser ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Fatty Acid ◽  
Early Detection ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein
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