scholarly journals Complex Reference Values for Endocrine and Special Chemistry Biomarkers across Pediatric, Adult, and Geriatric Ages: Establishment of Robust Pediatric and Adult Reference Intervals on the Basis of the Canadian Health Measures Survey

2015 ◽  
Vol 61 (8) ◽  
pp. 1063-1074 ◽  
Author(s):  
Khosrow Adeli ◽  
Victoria Higgins ◽  
Michelle Nieuwesteeg ◽  
Joshua E Raizman ◽  
Yunqi Chen ◽  
...  
Keyword(s):  
Reference Values ◽  
Reference Value ◽  
Reference Intervals ◽  
Specific Reference ◽  
Blood Samples ◽  
Health Measures ◽  
Laboratory Test Results ◽  
Canadian Health ◽  
Canadian Health Measures Survey ◽  
Age And Sex

Abstract BACKGROUND Defining laboratory biomarker reference values in a healthy population and understanding the fluctuations in biomarker concentrations throughout life and between sexes are critical to clinical interpretation of laboratory test results in different disease states. The Canadian Health Measures Survey (CHMS) has collected blood samples and health information from the Canadian household population. In collaboration with the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER), the data have been analyzed to determine reference value distributions and reference intervals for several endocrine and special chemistry biomarkers in pediatric, adult, and geriatric age groups. METHODS CHMS collected data and blood samples from thousands of community participants aged 3 to 79 years. We used serum samples to measure 13 immunoassay-based special chemistry and endocrine markers. We assessed reference value distributions and, after excluding outliers, calculated age- and sex-specific reference intervals, along with corresponding 90% CIs, according to CLSI C28-A3 guidelines. RESULTS We observed fluctuations in biomarker reference values across the pediatric, adult, and geriatric age range, with stratification required on the basis of age for all analytes. Additional sex partitions were required for apolipoprotein AI, homocysteine, ferritin, and high sensitivity C-reactive protein. CONCLUSIONS The unique collaboration between CALIPER and CHMS has enabled, for the first time, a detailed examination of the changes in various immunochemical markers that occur in healthy individuals of different ages. The robust age- and sex-specific reference intervals established in this study provide insight into the complex biological changes that take place throughout development and aging and will contribute to improved clinical test interpretation.

scholarly journals Biochemical Marker Reference Values across Pediatric, Adult, and Geriatric Ages: Establishment of Robust Pediatric and Adult Reference Intervals on the Basis of the Canadian Health Measures Survey

2015 ◽  
Vol 61 (8) ◽  
pp. 1049-1062 ◽  
Author(s):  
Khosrow Adeli ◽  
Victoria Higgins ◽  
Michelle Nieuwesteeg ◽  
Joshua E Raizman ◽  
Yunqi Chen ◽  
...  
Keyword(s):  
Health Information ◽  
Reference Values ◽  
Biochemical Markers ◽  
Biochemical Marker ◽  
Reference Intervals ◽  
Health Measures ◽  
Physical Measurements ◽  
Canadian Health ◽  
Canadian Health Measures Survey ◽  
Age And Sex

Abstract BACKGROUND Biological covariates such as age and sex can markedly influence biochemical marker reference values, but no comprehensive study has examined such changes across pediatric, adult, and geriatric ages. The Canadian Health Measures Survey (CHMS) collected comprehensive nationwide health information and blood samples from children and adults in the household population and, in collaboration with the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER), examined biological changes in biochemical markers from pediatric to geriatric age, establishing a comprehensive reference interval database for routine disease biomarkers. METHODS The CHMS collected health information, physical measurements, and biosamples (blood and urine) from approximately 12 000 Canadians aged 3–79 years and measured 24 biochemical markers with the Ortho Vitros 5600 FS analyzer or a manual microplate. By use of CLSI C28-A3 guidelines, we determined age- and sex-specific reference intervals, including corresponding 90% CIs, on the basis of specific exclusion criteria. RESULTS Biochemical marker reference values exhibited dynamic changes from pediatric to geriatric age. Most biochemical markers required some combination of age and/or sex partitioning. Two or more age partitions were required for all analytes except bicarbonate, which remained constant throughout life. Additional sex partitioning was required for most biomarkers, except bicarbonate, total cholesterol, total protein, urine iodine, and potassium. CONCLUSIONS Understanding the fluctuations in biochemical markers over a wide age range provides important insight into biological processes and facilitates clinical application of biochemical markers to monitor manifestation of various disease states. The CHMS-CALIPER collaboration addresses this important evidence gap and allows the establishment of robust pediatric and adult reference intervals.

scholarly journals Complex Biological Profile of Hematologic Markers across Pediatric, Adult, and Geriatric Ages: Establishment of Robust Pediatric and Adult Reference Intervals on the Basis of the Canadian Health Measures Survey

2015 ◽  
Vol 61 (8) ◽  
pp. 1075-1086 ◽  
Author(s):  
Khosrow Adeli ◽  
Joshua E Raizman ◽  
Yunqi Chen ◽  
Victoria Higgins ◽  
Michelle Nieuwesteeg ◽  
...  
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Reference Intervals ◽  
Mean Corpuscular Hemoglobin ◽  
Blood Cell Count ◽  
Corpuscular Hemoglobin ◽  
Health Measures ◽  
Canadian Health ◽  
Canadian Health Measures Survey ◽  
Age And Sex

AbstractBACKGROUNDIn a collaboration between the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) and the Canadian Health Measures Survey (CHMS), we determined reference value distributions using an a priori approach and created a comprehensive database of age- and sex-stratified reference intervals for clinically relevant hematologic parameters in a large household population of children and adults.METHODSThe CHMS collected data and blood samples from 11 999 respondents aged 3–79 years. Hematology markers were measured with either the Beckman Coulter HmX or Siemens Sysmex CA-500 Series analyzers. After applying exclusion criteria and removing outliers, we determined statistically relevant age and sex partitions and calculated reference intervals, including 90% CIs, according to CSLI C28-A3 guidelines.RESULTSHematology marker values showed dynamic changes from childhood into adulthood as well as between sexes, necessitating distinct partitions throughout life. Most age partitions were necessary during childhood, reflecting the hematologic changes that occur during growth and development. Hemoglobin, red blood cell count, hematocrit, and indices (mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration) increased with age, but females had lower hemoglobin and hematocrit starting at puberty. Platelet count gradually decreased with age and required multiple sex partitions during adolescence and adulthood. White blood cell count remained relatively constant over life, whereas fibrinogen increased slightly, requiring distinct age and sex partitions.CONCLUSIONSThe robust dataset generated in this study has allowed observation of dynamic biological profiles of several hematology markers and the establishment of comprehensive age- and sex-specific reference intervals that may contribute to accurate monitoring of pediatric, adult, and geriatric patients.

Pediatric and adult reference intervals for key endocrine and special chemistry markers based on the Canadian Health Measures Survey (CHMS)

2015 ◽  
Vol 48 (15) ◽  
pp. 1017-1018
Author(s):  
Joshua Raizman ◽  
Michelle Niewesteeg ◽  
Victoria Higgins ◽  
Yunqi Chen ◽  
Suzy Wong ◽  
...  
Keyword(s):  
Reference Intervals ◽  
Health Measures ◽  
Canadian Health ◽  
Canadian Health Measures Survey

scholarly journals Percentile curves for skinfold thickness for Canadian children and youth

PeerJ ◽  
2016 ◽  
Vol 4 ◽  
pp. e2247 ◽  
Author(s):  
Stefan Kuhle ◽  
Jillian Ashley-Martin ◽  
Bryan Maguire ◽  
David C. Hamilton
Keyword(s):  
Skinfold Thickness ◽  
Children And Youth ◽  
Feasible Method ◽  
Absolute Value ◽  
Health Measures ◽  
Percentile Curves ◽  
Canadian Health ◽  
First Time ◽  
Canadian Health Measures Survey ◽  
Age And Sex

Background.Skinfold thickness (SFT) measurements are a reliable and feasible method for assessing body fat in children but their use and interpretation is hindered by the scarcity of reference values in representative populations of children. The objective of the present study was to develop age- and sex-specific percentile curves for five SFT measures (biceps, triceps, subscapular, suprailiac, medial calf) in a representative population of Canadian children and youth.Methods.We analyzed data from 3,938 children and adolescents between 6 and 19 years of age who participated in the Canadian Health Measures Survey cycles 1 (2007/2009) and 2 (2009/2011). Standardized procedures were used to measure SFT. Age- and sex-specific centiles for SFT were calculated using the GAMLSS method.Results.Percentile curves were materially different in absolute value and shape for boys and girls. Percentile girls in girls steadily increased with age whereas percentile curves in boys were characterized by a pubertal centered peak.Conclusions.The current study has presented for the first time percentile curves for five SFT measures in a representative sample of Canadian children and youth.

scholarly journals Establishment of reference ranges for Serum Leptin and C-Peptide using enzymelinked immmunosorbent assay method: a preliminary report

2016 ◽  
Vol 2 (3) ◽  
pp. 483-487
Author(s):  
Mainasara Abdullah Sulaiman ◽  
Dahiru Shafi’u Gumel ◽  
Umar Zayyanu Usman ◽  
Anaja Peter Ocheni ◽  
Yakubu Abdulmumini ◽  
...  
Keyword(s):  
Reference Values ◽  
Clinical Laboratory ◽  
Reference Intervals ◽  
Assay Method ◽  
Specific Reference ◽  
Reference Ranges ◽  
Cross Sectional ◽  
Serum Leptin ◽  
C Peptide ◽  
Laboratory Test Results

Reference ranges (RR) or Reference Intervals (RIs) are very important values for accurate interpretation of clinical laboratory test results. Any test result that is not accompanied by a valid RR value is less informative and may not be interpreted correctly. However, reference values of most analytes for Nigerian population are not readily available. The present study aims at establishing reference values of Serum Leptin and C-Peptide for Dutse, Jigawa State. In a cross sectional study, eighty (80) reference individuals were recruited. Serum Leptin and C-Peptide were analysed using ELISA methods. Following an accepted guideline, population specific reference intervals were established for these analytes and found to be 3.13ng/mL to 14.09ng/mL for Leptin and 0.56ng/mL to 5.64ng/mL for C-Peptide, respectively. Populations sharing similar physical and socio-economic characteristics may adapt these intervals if validated and considered suitable for their laboratory methodsAsian J. Med. Biol. Res. September 2016, 2(3): 483-487

scholarly journals Age- and sex-specific reference intervals for blood urea nitrogen in Chinese general population

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Qingquan Liu ◽  
Yiru Wang ◽  
Zhi Chen ◽  
Xiaolin Guo ◽  
Yongman Lv
Keyword(s):  
Blood Urea Nitrogen ◽  
Linear Regression Analysis ◽  
Reference Value ◽  
Multiple Linear Regression Analysis ◽  
Reference Intervals ◽  
Specific Reference ◽  
Cross Sectional ◽  
Urea Nitrogen ◽  
Specific Distribution ◽  
Age And Sex

AbstractBlood urea nitrogen (BUN) is a nitrogenous end product of protein metabolism. This study aims to explore the age- and sex-specific distribution of BUN among healthy Chinese adults. A total of 24,006 BUN values from healthy adults (14,148 males and 9858 females) were included in the cross-sectional study. Males had a higher median BUN value compared to females (4.6 mmol/L vs. 4.1 mmol/L). BUN values showed a positive correlation with body mass index (BMI), cholesterol, and blood sugar (P < 0.0001). However, eGFR showed a negative correlation with the BUN reference value (P < 0.0001) in both sexes. Multiple linear regression analysis confirmed that the positive associations of BUN levels and age were statistically significant after adjusting confounding factors (P < 0.001). Thus, the serum BUN values increased by 0.21 mmol/L for males and 0.282 mmol/L for females per 10 years. The BUN values corresponding to the 1st, 2.5th, 50th, 97.5th, and 99th percentiles for any specific age in both sex were also calculated. These results indicate that the serum BUN reference value is significantly affected by age and gender, and thus, its interpretation is age- and sex-dependent.

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