Religious attendance and frequency of alcohol use: same genes or same environments: a bivariate extended twin kinship model

Twin Research ◽  
1999 ◽  
Vol 2 (2) ◽  
pp. 169-179 ◽  
Author(s):  
Hermine H Maes ◽  
Michael C Neale ◽  
Nicholas G Martin ◽  
Andrew C Heath ◽  
Lindon J Eaves
Keyword(s):  
Alcohol Use ◽  
Environmental Factors ◽  
Cultural Transmission ◽  
Genetic Factors ◽  
Church Attendance ◽  
Family Resemblance ◽  
Religious Attendance ◽  
Bivariate Model ◽  
The Relationship

AbstractReligious attendance has been shown to correlate negatively with alcohol use. We investigated whether this relationship is driven by genetic or environmental factors. Data on frequency of church attendance and frequency of alcohol use were obtained from twins and their families in the Virginia 30 000 study. A comprehensive bivariate model of family resemblance was fitted to the data using Mx. This model is described in detail. Results indicate that genetic factors primarily account for the relationship between alcohol and church attendance in males, whilst shared environmental factors, including cultural transmission and genotype-environment covariance, are stronger determinants of this association in females.

New Approaches to Old Problems: The Well-Being of the Population of Russia from 1821 to 1910 as Measured by Physical Stature

Slavic Review ◽  
1999 ◽  
Vol 58 (1) ◽  
pp. 1-26 ◽  
Author(s):  
Boris N. Mironov
Keyword(s):  
Quality Of Life ◽  
Environmental Factors ◽  
Medical Care ◽  
Genetic Factors ◽  
Well Being ◽  
Living Conditions ◽  
Physical Stature ◽  
The Relationship ◽  
Conditions Of Work

Scholars generally agree on the relationship between the physical stature, or height, of children and adults, and their quality of life, or their biological status, including diet, illnesses, intensity and conditions of work, availability of medical care, living conditions, psychological well-being, climate, water, air, and other environmental factors that have impinged on their lives prior to the point at which their height is measured. Genetic factors have an important effect on individual height, but genetic distinctions lose their significance when masses of individuals are measured and average heights are compared. The same effect holds at the level of entire populations: differences in height are determined, not by ethnic or racial attributes, but by living conditions.

scholarly journals Disentangling the relationships between maternal smoking during pregnancy and co-occurring risk factors

2011 ◽  
Vol 42 (7) ◽  
pp. 1547-1557 ◽  
Author(s):  
J. M. Ellingson ◽  
M. E. Rickert ◽  
P. Lichtenstein ◽  
N. Långström ◽  
B. M. D'Onofrio
Keyword(s):  
Risk Factors ◽  
Environmental Factors ◽  
Maternal Smoking ◽  
Genetic Factors ◽  
Familial Risk ◽  
Smoking During Pregnancy ◽  
Familial Risk Factors ◽  
Maternal Smoking During Pregnancy ◽  
Drug Problems ◽  
The Relationship

BackgroundMaternal smoking during pregnancy (SDP) has been studied extensively as a risk factor for adverse offspring outcomes and is known to co-occur with other familial risk factors. Accounting for general familial risk factors has attenuated associations between SDP and adverse offspring outcomes, and identifying these confounds will be crucial to elucidating the relationship between SDP and its psychological correlates.MethodThe current study aimed to disentangle the relationship between maternal SDP and co-occurring risk factors (maternal criminal activity, drug problems, teen pregnancy, educational attainment, and cohabitation at childbirth) using a population-based sample of full- (n=206 313) and half-sister pairs (n=19 363) from Sweden. Logistic regression models estimated the strength of association between SDP and co-occurring risk factors. Bivariate behavioral genetic models estimated the degree to which associations between SDP and co-occurring risk factors are attributable to genetic and environmental factors.ResultsMaternal SDP was associated with an increase in all co-occurring risk factors. Of the variance associated with SDP, 45% was attributed to genetic factors and 53% was attributed to unshared environmental factors. In bivariate models, genetic factors accounted for 21% (non-drug-, non-violence-related crimes) to 35% (drug-related crimes) of the covariance between SDP and co-occurring risk factors. Unshared environmental factors accounted for the remaining covariance.ConclusionsThe genetic factors that influence a woman's criminal behavior, substance abuse and her offspring's rearing environment all influence SDP. Therefore, the intergenerational transmission of genes conferring risk for antisocial behavior and substance misuse may influence the associations between maternal SDP and adverse offspring outcomes.

scholarly journals Genetic origin of the relationship between parental negativity and behavior problems from early childhood to adolescence: A longitudinal genetically sensitive study

2013 ◽  
Vol 25 (2) ◽  
pp. 487-500 ◽  
Author(s):  
Silvia Alemany ◽  
Frühling V. Rijsdijk ◽  
Claire Margaret Alison Haworth ◽  
Lourdes Fañanás ◽  
Robert Plomin
Keyword(s):  
Early Childhood ◽  
Environmental Factors ◽  
Behavior Problems ◽  
Genetic Factors ◽  
Causal Pathways ◽  
Longitudinal Association ◽  
Genetic And Environmental Factors ◽  
And Behavior ◽  
The Relationship

AbstractLittle is known about how genetic and environmental factors contribute to the association between parental negativity and behavior problems from early childhood to adolescence. The current study fitted a cross-lagged model in a sample consisting of 4,075 twin pairs to explore (a) the role of genetic and environmental factors in the relationship between parental negativity and behavior problems from age 4 to age 12, (b) whether parent-driven and child-driven processes independently explain the association, and (c) whether there are sex differences in this relationship. Both phenotypes showed substantial genetic influence at both ages. The concurrent overlap between them was mainly accounted for by genetic factors. Causal pathways representing stability of the phenotypes and parent-driven and child-driven effects significantly and independently account for the association. Significant but slight differences were found between males and females for parent-driven effects. These results were highly similar when general cognitive ability was added as a covariate. In summary, the longitudinal association between parental negativity and behavior problems seems to be bidirectional and mainly accounted for by genetic factors. Furthermore, child-driven effects were mainly genetically mediated, and parent-driven effects were a function of both genetic and shared-environmental factors.

Marital Satisfaction, Conflict Resolution Styles, and Religious Attendance Among Latino Couples

2017 ◽  
Vol 25 (3) ◽  
pp. 215-223 ◽  
Author(s):  
Morgan A. Stinson ◽  
J. María Bermúdez ◽  
Jerry Gale ◽  
Denise Lewis ◽  
Andrea S. Meyer ◽  
...  
Keyword(s):  
Conflict Resolution ◽  
Marital Satisfaction ◽  
Church Attendance ◽  
Religious Attendance ◽  
Family Therapists ◽  
Actor Partner Interdependence Model ◽  
Conflict Resolution Styles ◽  
Latino Couples ◽  
The Relationship

Research related to the process of communication among couples is central to the work of couple and family therapists. This study examines the relationship between couple’s conflict resolution styles, weekly church attendance, and marital satisfaction. Specifically, we surveyed 191 Latino couples using Gottman’s typology of conflict resolution styles (e.g., validator, avoidant, and volatile) to identify which style predicted marital satisfaction for both partners. Using the actor–partner interdependence model, we find a multifaceted picture of how partner’s conflict resolution style influences theirs and their partner’s marital satisfaction.

scholarly journals Relationship Between Parental Big Five And Children’s Ability To Delay Gratification

2021 ◽  
Author(s):  
Pauline S. Effenberger ◽  
Fabian Streit ◽  
Svenja Bardtke ◽  
Maria Gilles ◽  
Isabell A.-C. Wolf ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Waiting Time ◽  
Genetic Factors ◽  
Delay Of Gratification ◽  
Openness To Experience ◽  
Paternal Effects ◽  
Future Studies ◽  
Parental Personality ◽  
Neo Five Factor Inventory ◽  
The Relationship

AbstractThe ability to delay gratification is related to success in school and other aspects of life. Genetic as well as environmental factors such as parenting style partly explain the development of delay of gratification (DoG). However, it is unclear whether parental personality impacts children’s DoG, and how maternal and paternal personalities contribute to this relationship. The present study investigates the relationship between parental personality and 45-month-old children’s DoG (N = 329). Personality was measured using the NEO-Five-Factor-Inventory-30, DoG was operationalized through waiting time in the marshmallow test. In model 1, using only maternal data to predict DoG, maternal openness to experience was associated with shorter waiting time of the child in the marshmallow test, whereas maternal agreeableness was associated with longer waiting time. In model 2, using only paternal data to predict DoG, paternal agreeableness was related to longer waiting time. In model 3, combining maternal and paternal data to predict DoG, maternal openness to experience as well as paternal agreeableness remained significant predictors of DoG. The present study underlines the influence of both parents’ personalities on the development of children’s DoG and indicates differential maternal and paternal effects. Future studies should investigate the relationship between parental personality and children’s DoG in detail and take further factors into account, such as genetic factors, other environmental factors and the personality of the child.

scholarly journals Flexible Mx Specification of Various Extended Twin Kinship Designs

2009 ◽  
Vol 12 (1) ◽  
pp. 26-34 ◽  
Author(s):  
Hermine H. Maes ◽  
Michael C. Neale ◽  
Sarah E. Medland ◽  
Matthew C. Keller ◽  
Nicholas G. Martin ◽  
...  
Keyword(s):  
Cultural Transmission ◽  
Church Attendance ◽  
Smoking Status ◽  
Family Resemblance ◽  
Multiple Phenotypes ◽  
Expression Of Genes ◽  
Children Of Twins ◽  
Genes And Environment ◽  
Simultaneous Testing ◽  
Estimation Of Variance

AbstractThe extended twin kinship design allows the simultaneous testing of additive and nonadditive genetic, shared and individual-specific environmental factors, as well as sex differences in the expression of genes and environment in the presence of assortative mating and combined genetic and cultural transmission (Eaves et al., 1999). It also handles the contribution of these sources of variance to the (co)variation of multiple phenotypes. Keller et al. (2008) extended this comprehensive model for family resemblance to allow or a flexible specification of assortment and vertical transmission. As such, it provides a general framework which can easily be reduced to fit subsets of data such as twin-parent data, children-of-twins data, etc. A flexible Mx specification of this model that allows handling of these various designs is presented in detail and applied to data from the Virginia 30,000. Data on height, body mass index, smoking status, church attendance, and political affiliation were obtained from twins and their families. Results indicate that biases in the estimation of variance components depend both on the types of relative available for analysis, and on the underlying genetic and environmental architecture of the phenotype of interest.

scholarly journals Genetic and Environmental Etiology of the Relationship Between Childhood Hyperactivity/Inattention and Conduct Problems in a South Korean Twin Sample

2015 ◽  
Vol 18 (3) ◽  
pp. 290-297 ◽  
Author(s):  
Yoon-Mi Hur
Keyword(s):  
Conduct Problems ◽  
Genetic Factors ◽  
Additive Genetic Variance ◽  
Model Fitting ◽  
Twin Studies ◽  
Phenotypic Correlation ◽  
Comorbid Condition ◽  
Bivariate Model ◽  
New Finding ◽  
The Relationship

Recently, there has been increased research into the etiology of the comorbidity between hyperactivity/inattention problems (HIP) and conduct problems (CP). However, the nature of the etiology of the comorbidity has remained unclear. Mothers of 507 pairs of twins, comprised of 221 monozygotic (MZ) and 286 dizygotic (DZ) twin pairs aged from 6 to 13 years (mean = 9.6 years; SD = 2.0 years), completed the HIP and the CP scale of the Strengths and Difficulties Questionnaire (SDQ) via a telephone interview. The phenotypic correlation between HIP and CP was 0.43 (p < .01). MZ and DZ twin correlations were, respectively, 0.48 (95%CI: 0.37–0.58) and 0.06 (95%CI: -0.06–0.19) for HIP and 0.38 (95%CI: 0.26–0.49) and 0.35 (95%CI: 0.25–0.45) for CP. The bivariate model-fitting results revealed additive genetic correlation of 1.0 (95% CI: 0.72–1.00), a complete overlap of additive genetic variance component between HIP and CP, supporting the importance of correlated additive genetic risk factors for the comorbid condition of HIP and CP. HIP was additionally influenced by non-additive genetic factors that did not contribute to the relationship between HIP and CP. There was a significant but moderate child-specific environmental correlation (re = 0.37) between HIP and CP. CP was additionally influenced by shared family environmental influences. While the results of the present study are generally consistent with the findings from Western twin studies of the relationship between HIP and CP, they add a new finding to the extant literature by showing that it is additive rather than non-additive genetic factors that are responsible for the co-occurrence of HIP and CP.

Молекулярная биология менингиом головного мозга

2017 ◽  
pp. 82-91
Author(s):  
В.А. Бывальцев ◽  
И.А. Степанов ◽  
Е.Г. Белых ◽  
А.И. Яруллина
Keyword(s):  
Gene Therapy ◽  
Proton Therapy ◽  
Genetic Factors ◽  
Intracranial Tumor ◽  
Molecular Profile ◽  
Genetic Changes ◽  
Treatment Techniques ◽  
Downstream Effects ◽  
Si Rna ◽  
The Relationship

Цель обзора - анализ современных данных литературы о нарушении внутриклеточных сигнальных путей, играющих ведущую роль в развитии менингиом, генетических и молекулярных профилях данной группы опухолей. К настоящему времени изучено множество аберрантных сигнальных внутриклеточных путей, которые играют важнейшую роль в развитии менингиом головного мозга. Четкое понимание поврежденных внутриклеточных каскадов поможет изучить влияние генетических мутаций и их эффектов на менингиомогенез. Подробное исследование генетического и молекулярного профиля менингиом позволит сделать первый уверенный шаг в разработке более эффективных методов лечения данной группы интракраниальных опухолей. Хромосомы 1, 10, 14, 22 и связанные с ними генные мутации ответственны за рост и прогрессию менингиом. Предполагается, что только через понимание данных генетических повреждений будут реализованы новейшие эффективные методы лечения. Будущая терапия будет включать в себя комбинации таргетных молекулярных агентов, в том числе генную терапию, малые интерферирующие РНК, протонную терапию и другие методы воздействия, как результат дальнейшего изучения генетических и биологических изменений, характерных для менингеальных опухолей. Meningiomas are by far the most common tumors arising from the meninges. A myriad of aberrant signaling pathways involved with meningioma tumorigenesis, have been discovered. Understanding these disrupted pathways will aid in deciphering the relationship between various genetic changes and their downstream effects on meningioma pathogenesis. An understanding of the genetic and molecular profile of meningioma would provide a valuable first step towards developing more effective treatments for this intracranial tumor. Chromosomes 1, 10, 14, 22, their associated genes, have been linked to meningioma proliferation and progression. It is presumed that through an understanding of these genetic factors, more educated meningioma treatment techniques can be implemented. Future therapies will include combinations of targeted molecular agents including gene therapy, si-RNA mediation, proton therapy, and other approaches as a result of continued progress in the understanding of genetic and biological changes associated with meningiomas.

scholarly journals Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans

Leukemia ◽  
2021 ◽  
Author(s):  
Geffen Kleinstern ◽  
J. Brice Weinberg ◽  
Sameer A. Parikh ◽  
Esteban Braggio ◽  
Sara J. Achenbach ◽  
...  
Keyword(s):  
Environmental Factors ◽  
B Cell ◽  
Risk Score ◽  
Genetic Factors ◽  
Strong Predictor ◽  
Lymphocytic Leukemia ◽  
European Ancestry ◽  
Polygenic Risk Score ◽  
Polygenic Risk ◽  
C Statistic

AbstractMonoclonal B-cell lymphocytosis (MBL) is a precursor to CLL. Other than age, sex, and CLL family-history, little is known about factors associated with MBL risk. A polygenic-risk-score (PRS) of 41 CLL-susceptibility variants has been found to be associated with CLL risk among individuals of European-ancestry(EA). Here, we evaluate these variants, the PRS, and environmental factors for MBL risk. We also evaluate these variants and the CLL-PRS among African-American (AA) and EA-CLL cases and controls. Our study included 560 EA MBLs, 869 CLLs (696 EA/173 AA), and 2866 controls (2631 EA/235 AA). We used logistic regression, adjusting for age and sex, to estimate odds ratios (OR) and 95% confidence intervals within each race. We found significant associations with MBL risk among 21 of 41 variants and with the CLL-PRS (OR = 1.86, P = 1.9 × 10−29, c-statistic = 0.72). Little evidence of any association between MBL risk and environmental factors was observed. We observed significant associations of the CLL-PRS with EA-CLL risk (OR = 2.53, P = 4.0 × 10−63, c-statistic = 0.77) and AA-CLL risk (OR = 1.76, P = 5.1 × 10−5, c-statistic = 0.62). Inherited genetic factors and not environmental are associated with MBL risk. In particular, the CLL-PRS is a strong predictor for both risk of MBL and EA-CLL, but less so for AA-CLL supporting the need for further work in this population.

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