Short Sleep Duration Insomnia May Be Associated With Increased Cardiovascular Disease in Schizophrenics

ObjectivesWe analysed association between short sleep duration and prevalence of cardiovascular disease (CVD) in a multiethnic population living in the Netherlands, and the contribution of short sleep to the observed ethnic differences in the prevalence of CVD, independent of CVD risk factors.Methods20 730 participants (aged 18–71 years) of the HELIUS (Healthy Life in an Urban Setting) Study were investigated. Self-reported sleep duration was classified as: short (<7 hours/night) and healthy (7–9 hours/night). Prevalence of CVD was assessed using the Rose Questionnaire on angina pectoris, intermittent claudication and possible myocardial infarction. Association of short sleep duration with prevalent CVD and the contribution of short sleep to the observed ethnic differences in the prevalence of CVD were analysed using adjusted prevalence ratio(s) (PRs) with 95% CI.ResultsResults indicate that short sleep was associated with CVD among all ethnic groups with PRs ranging from 1.41 (95% CI 1.21 to 1.65) in Moroccans to 1.62 (95% CI 1.20 to 2.18) in Dutch after adjustment for age, sex and conventional CVD risk factors. The independent contributions of short sleep (in percentage) to ethnic differences in CVD compared with Dutch were 10%, 15%, 15%, 5% and 5% in South-Asian Surinamese, African-Surinamese, Ghanaian, Turkish and Moroccan, respectively.ConclusionShort sleep contributed to ethnic differences in CVD independent of well-known CVD risk factors particularly in Surinamese and Ghanaian groups. Reducing sleep deprivation may be a relevant entry point for reducing increased CVD risks among the various ethnic minority groups.

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1015 IMPACT OF SHORT SLEEP DURATION ON MORTALITY RISK ASSOCIATED WITH CARDIOVASCULAR DISEASE AND STROKE

SLEEP ◽

10.1093/sleepj/zsx050.1014 ◽

2017 ◽

Vol 40 (suppl_1) ◽

pp. A378-A378

Author(s):

J Fernandez-Mendoza ◽

F He ◽

AN Vgontzas ◽

D Liao ◽

EO Bixler

Keyword(s):

Cardiovascular Disease ◽

Sleep Duration ◽

Mortality Risk ◽

Short Sleep Duration ◽

Short Sleep

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Abstract P072: Short Sleep Duration is Associated with Elevated Homocysteine Levels

Circulation ◽

10.1161/circ.131.suppl_1.p072 ◽

2015 ◽

Vol 131 (suppl_1) ◽

Author(s):

Megan E Petrov ◽

Michael A Grandner ◽

Carol M Baldwin ◽

Matthew P Buman ◽

Shawn D Youngstedt

Keyword(s):

Cardiovascular Disease ◽

Sleep Duration ◽

Multinomial Logistic Regression ◽

Menopausal Status ◽

Short Sleep Duration ◽

Dietary Folate ◽

Short Sleep ◽

Long Sleep ◽

History Of ◽

The Relationship

Introduction: Short and long sleep durations are associated with heightened risk for cardiovascular disease and vascular risk factors. Elevated homocysteine is also associated with greater risk for cardiovascular disease; however, studies have yet to investigate the relationship between sleep duration and homocysteine. Hypothesis: We hypothesized that short and long sleep duration would be associated with clinical levels of homocysteine. Methods: Adults (n=2,469; ≥20y) from the 2005-2006 National Health and Nutrition Examination Survey (NHANES) were assessed for habitual sleep duration (coded as <5, 5, 6, 7, 8, 9, and ≥10hrs) and fasting plasma homocysteine levels (<10 [normative], 10 to <15 [pre-clinical] and ≥15 [clinical] μmol/L). Participants were excluded if pregnant, lactating, missing data on the primary variables, or if they had a history of cardiovascular disease, cancer, diabetes, kidney disease, or diagnosed sleep disorder. Population weighted, multinomial logistic regression analyses assessed the relationship between sleep duration and homocysteine after adjustment for age, sex, race/ethnicity, marital and menopausal status, shift work, dietary folate, alcohol intake, cotinine levels, reported physical activity, hypertension, and reported frequency of cessation of breathing at night. Results: Pre-clinical and clinical levels of homocysteine were present in 13.7% and 2.5% of the sample, respectively. The mean sleep duration was 6.9 ± 1.4 hours. In adjusted analyses, sleep duration was significantly related to homocysteine ( p < 0.001). See Table. Very short sleepers (<5hrs) were more likely to have clinical levels of homocysteine (OR: 3.01, 95%CI: 1.38, 6.57) compared to 7-hr sleepers. Conclusions: In a U.S. representative sample of adults without cardiovascular disease or other major conditions, short sleepers were at greater odds for clinical levels of homocysteine Findings suggest that homocysteine may be one mechanism linking short sleep duration to cardiovascular disease.

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Individual differences in habitual short sleep duration and dysfunction: Subjective health versus objective cardiovascular disease risk.

Health Psychology ◽

10.1037/hea0001085 ◽

2021 ◽

Vol 40 (9) ◽

pp. 587-596

Author(s):

Paula G. Williams ◽

Steven D. Barger ◽

Brian J. Curtis

Keyword(s):

Cardiovascular Disease ◽

Individual Differences ◽

Sleep Duration ◽

Disease Risk ◽

Cardiovascular Disease Risk ◽

Subjective Health ◽

Short Sleep Duration ◽

Short Sleep

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Insomnia with objective short sleep duration and risk of incident cardiovascular disease and all-cause mortality: Sleep Heart Health Study

SLEEP ◽

10.1093/sleep/zsy047 ◽

2018 ◽

Vol 41 (6) ◽

Cited By ~ 53

Author(s):

Suzanne M Bertisch ◽

Benjamin D Pollock ◽

Murray A Mittleman ◽

Daniel J Buysse ◽

Lydia A Bazzano ◽

...

Keyword(s):

Cardiovascular Disease ◽

Sleep Duration ◽

Health Study ◽

Heart Health ◽

Short Sleep Duration ◽

Short Sleep ◽

All Cause Mortality ◽

Incident Cardiovascular Disease

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Insomnia Symptoms and Cardiovascular Disease among Older American Indians: The Native Elder Care Study

Journal of Environmental and Public Health ◽

10.1155/2011/964617 ◽

2011 ◽

Vol 2011 ◽

pp. 1-6 ◽

Cited By ~ 14

Author(s):

Charumathi Sabanayagam ◽

Anoop Shankar ◽

Dedra Buchwald ◽

R. Turner Goins

Keyword(s):

Cardiovascular Disease ◽

Sleep Duration ◽

American Indians ◽

Daytime Sleepiness ◽

Elder Care ◽

Short Sleep Duration ◽

Short Sleep ◽

Falling Asleep ◽

Insomnia Symptoms ◽

Care Study

Background. Cardiovascular disease (CVD) is the leading cause of death among American Indians. It is not known if symptoms of insomnia are associated with CVD in this population.Methods. We examined 449 American Indians aged ≥55 years from the Native Elder Care Study. The main outcome-of-interest was self-reported CVD.Results. Short sleep duration, daytime sleepiness, and difficulty falling asleep were positively associated with CVD after adjusting for demographic, lifestyle, and clinical risk factors. Compared with a sleep duration of 7 h, the multivariable odds ratio (OR) (95% confidence interval [CI]) of CVD among those with sleep duration ≤5 h was 2.89 (1.17–7.16). Similarly, the multivariable OR (95% CI) of CVD was 4.45 (1.85–10.72) and 2.60 (1.25–5.42) for daytime sleepiness >2 h and difficulty falling asleep often/always.Conclusion. Symptoms of insomnia including short sleep duration, daytime sleepiness, and difficulty falling asleep are independently associated with CVD in American Indians aged ≥55 years.

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Supplemental Material for Individual Differences in Habitual Short Sleep Duration and Dysfunction: Subjective Health Versus Objective Cardiovascular Disease Risk

Health Psychology ◽

10.1037/hea0001085.supp ◽

2021 ◽

Keyword(s):

Cardiovascular Disease ◽

Individual Differences ◽

Sleep Duration ◽

Disease Risk ◽

Cardiovascular Disease Risk ◽

Subjective Health ◽

Short Sleep Duration ◽

Short Sleep

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2.1-O5The contribution of short sleep duration to ethnic differences in cardiovascular disease in the Netherlands - the HELIUS study

European Journal of Public Health ◽

10.1093/eurpub/cky047.043 ◽

2018 ◽

Vol 28 (suppl_1) ◽

Author(s):

K Anujuo ◽

C Agyemang ◽

M Snijder ◽

G Jean-Louis ◽

B van den Born ◽

...

Keyword(s):

Cardiovascular Disease ◽

The Netherlands ◽

Sleep Duration ◽

Ethnic Differences ◽

Short Sleep Duration ◽

Short Sleep ◽

Helius Study

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Sleep duration and apolipoprotein B in metabolically healthy and unhealthy overweight/obese phenotypes: a cross-sectional study in Chinese adults

BMJ Open ◽

10.1136/bmjopen-2018-023817 ◽

2019 ◽

Vol 9 (2) ◽

pp. e023817 ◽

Cited By ~ 2

Author(s):

Huihui Ren ◽

Lu Zhang ◽

Zhelong Liu ◽

Xinrong Zhou ◽

Gang Yuan

Keyword(s):

Cardiovascular Disease ◽

Sleep Duration ◽

Apolipoprotein B ◽

Cross Sectional Study ◽

Sectional Study ◽

Short Sleep Duration ◽

Cross Sectional ◽

Short Sleep ◽

Increased Risk ◽

Metabolically Healthy

ObjectivesShort sleep duration is independently associated with an increased risk of developing cardiovascular disease; however, the association has not yet been examined in obese populations. We assessed the associations between sleep duration, metabolic phenotype and apolipoprotein variables in a nationally representative Chinese population with overweight/obesity.Study designCross-sectional study.SettingsThe study conducted in nine provinces of China that vary substantially in geography and economic development.PatientsData were obtained from 4149 adults with overweight/obesity aged 18 to 94 years from the 2009 China Health and Nutrition Survey. Sleep duration was categorised as ≤6, 7–8 or ≥9 hour. Phenotypes were determined based on body mass index and metabolic health status and categorised as metabolically healthy overweight/obesity (MHOO) and metabolically unhealthy overweight/obesity (MUOO).Main outcome measureThe outcome variables were elevated apolipoproteins.ResultsCompared with MHOO phenotype, MUOO phenotypes were more likely to report shorter sleep duration (12.2%vs9%). In the MUOO group, the multivariate-adjusted OR (95% CI) for elevated apolipoprotein B (apoB) was 1.66 (1.23 to 2.23) for those with ≤6 hours of sleep and 1.12 (0.86 to 1.45) for those with ≥9 hours of sleep, using 7–8 hours of sleep as a reference. Similar results were obtained in the subgroup of subjects who were ≥45 or<45 years old, but shorter sleep duration was more strongly associated with elevated apoB in those <45 years (p interaction=0.023). However, no association was observed in the MHOO phenotype.ConclusionsThe high prevalence of short sleep duration and its strong association with elevated apoB in adults who are metabolically unhealthy overweight/obese suggest an increased risk of cardiovascular disease in this population. The differences in sleep sufficiency among obese phenotypes may account for the disparities in their cardiovascular outcomes.

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