Environmental Causes of Cancer of the Lung Other Than Tobacco Smoke

AbstractEnvironmental factors which cause asthma are those that induce airway inflammation with eosinophils (more common) or neutrophils along with airway hyperresponsiveness (AHR). The most common of these (indeed the most common cause of asthma) are IgE-mediated inhalant allergen exposures. Allergen-induced AHR and inflammation are both associated with the allergen-induced late asthmatic response (LAR). Although allergens were previously recognized only as causes of symptoms and bronchoconstriction in asthmatics, we now appreciate them as causes of the fundamental pathophysiologic features of asthma. Low-molecular-weight chemical sensitizers, causes of occupational asthma, also cause asthma in a manner analogous to allergen. Acute irritant-induced asthma (reactive airways dysfunction syndrome) following a very heavy irritant exposure and chronic irritant-induced asthma following repeated high exposures can also induce persistent or permanent changes (inflammation and AHR) consistent with asthma. Textile dust exposure produces a different form of airway disease (byssinosis) which is less frequently observed currently. Environmental exposure to tobacco smoke facilitates the development of asthma in children. Personal smoking and environmental air pollution have an inconsistent and likely generally small effect in causing asthma.

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Impact of Prenatal Tobacco Smoke Exposure, as Measured by Midgestation Serum Cotinine Levels, on Fetal Biometry and Umbilical Flow Velocity Waveforms

Yearbook of Obstetrics Gynecology and Women s Health ◽

10.1016/s1090-798x(08)70330-8 ◽

2006 ◽

Vol 2006 ◽

pp. 55-57

Author(s):

S.H. Ural

Keyword(s):

Flow Velocity ◽

Tobacco Smoke ◽

Smoke Exposure ◽

Tobacco Smoke Exposure ◽

Serum Cotinine ◽

Fetal Biometry

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Prenatal Environmental Tobacco Smoke Exposure Promotes Adult Atherogenesis and Mitochondrial Damage in Apolipoprotein E−/− Mice Fed a Chow Diet

Yearbook of Obstetrics Gynecology and Women s Health ◽

10.1016/s1090-798x(08)70314-x ◽

2006 ◽

Vol 2006 ◽

pp. 29-30

Author(s):

S.E. Bulun

Keyword(s):

Apolipoprotein E ◽

Environmental Tobacco Smoke ◽

Tobacco Smoke ◽

Environmental Tobacco Smoke Exposure ◽

Mitochondrial Damage ◽

Smoke Exposure ◽

Tobacco Smoke Exposure ◽

Chow Diet

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Effects of Restaurant and Bar Smoking Regulations on Exposure to Environmental Tobacco Smoke Among Massachusetts Adults

Yearbook of Pulmonary Disease ◽

10.1016/s8756-3452(08)70081-1 ◽

2006 ◽

Vol 2006 ◽

pp. 95-96

Author(s):

L.T. Tanoue

Keyword(s):

Environmental Tobacco Smoke ◽

Tobacco Smoke

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Case 2: Recurrent thromboembolism despite adequate oral anticoagulation – Trousseau’s syndrome

Therapeutische Umschau ◽

10.1024/0040-5930.56.9.481 ◽

1999 ◽

Vol 56 (9) ◽

pp. 481-483

Author(s):

Züger ◽

Demarmels Biasiutti

Keyword(s):

Oral Anticoagulation ◽

Cell Cancer ◽

Small Cell ◽

Niedermolekulares Heparin ◽

Small Cell Cancer ◽

Trousseau’S Syndrome ◽

Cancer Of The Lung

Wir berichten über einen 76jährigen Patienten, welcher trotz gut eingestellter oraler Antikoagulation mit Phenprocoumon rezidivierende Thrombosen erlitt bei leichtgradiger chronischer disseminierter intravasaler Gerinnung. Die Abklärungen ergaben das Vorliegen eines Bronchus-Karzinoms (Non small cell cancer of the lung, NSCCL) mit hilären und mediastinalen Lymphknotenmetastasen. Aufgrund der Assoziation von rezidivierenden Thrombosen, aktivierter Gerinnung und Tumorleiden wurde die Diagnose eines Trousseau Syndroms gestellt. Basierend auf Fallberichten aus der Literatur wurde die Therapie auf intravenöses Heparin gewechselt, welches die thrombotische Koagulopathie stoppte. Aus praktischen Gründen erfolgte dann eine Umstellung der Therapie auf subcutanes niedermolekulares Heparin in therapeutischer Dosierung, welches während 6.5 Monaten ebenso effektiv war und eine Alternative zur etablierten Therapie mit unfraktioniertem Heparin bei Trousseau Syndrom darstellen dürfte.

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Impact of Moderate Prenatal Alcohol Exposure on Problem Behaviors in Preschool and School Children

Zeitschrift für Entwicklungspsychologie und Pädagogische Psychologie ◽

10.1026/0049-8637/a000106 ◽

2014 ◽

Vol 46 (2) ◽

pp. 89-100 ◽

Cited By ~ 1

Author(s):

Manuela Pfinder ◽

Stefan Liebig ◽

Reinhold Feldmann

Keyword(s):

Problem Behaviors ◽

Tobacco Smoke ◽

Prenatal Alcohol Exposure ◽

Alcohol Exposure ◽

Smoke Exposure ◽

Low Ses ◽

German Health ◽

Kiggs Study ◽

Strengths And Difficulties ◽

Prenatal Alcohol

Data on the relation between moderate prenatal alcohol exposure (PAE) and behavioral disorders are inconsistent, and this raises new questions. We examined (1) the association between moderate PAE and problem behaviors and (2) whether these associations differed by levels of socioeconomic status (SES), fetal smoke exposure, or exposure to environmental tobacco smoke (ETS). Data were taken from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) study. Parents evaluated children’s behaviors using the Strengths and Difficulties Questionnaire (SDQ). Results showed a slight, but insignificant, increase of problem behaviors in children with moderate PAE. In 3- to 6-year-olds, PAE had a stronger effect on hyperactivity/inattention in combination with fetal smoke exposure (odds ratio = 2.82), than did PAE alone. Effects were not stronger in low-SES children, but they were stronger in children with ETS. We conclude that moderate PAE might have adverse effects on neurodevelopment, with stronger effects in disadvantaged populations. To confirm our preliminary findings, further research should be conducted.

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