Nitric Oxide Modulates Leukocyte-Endothelial Cell Adhesion

2003 ◽  
pp. 139-151 ◽  
Author(s):  
Wolfgang Cerwinka ◽  
D. Neil Granger
Keyword(s):  
Nitric Oxide ◽  
Cell Adhesion ◽  
Endothelial Cell ◽  
Endothelial Cell Adhesion

Modulation of oxidized low-density lipoprotein-induced microvascular dysfunction by nitric oxide

1995 ◽  
Vol 268 (4) ◽  
pp. H1643-H1650 ◽  
Author(s):  
L. Liao ◽  
D. N. Granger
Keyword(s):  
Nitric Oxide ◽  
Mast Cell ◽  
Cell Adhesion ◽  
Endothelial Cell ◽  
Microvascular Dysfunction ◽  
Mast Cell Degranulation ◽  
Low Density ◽  
No Donors ◽  
Albumin Leakage ◽  
Endothelial Cell Adhesion

The objectives of this study were to determine 1) whether the leukocyte-endothelial cell adhesion in postcapillary venules elicited by copper-oxidized low-density lipoproteins (Cu-LDL) is accompanied by enhanced vascular albumin leakage and mast cell degranulation and 2) whether nitric oxide (NO) donors attenuate the Cu-LDL-induced microvascular dysfunction. Infusion of Cu-LDL, but not normal LDL, caused significant increases in leukocyte rolling, adherence, emigration, mast cell degranulation, and an enhanced albumin leakage in rat mesenteric venules. Treatment with the NO donors sodium nitroprusside and spermine-NO or pretreatment with superoxide dismutase or L-arginine significantly reduced the Cu-LDL-induced leukocyte adherence, emigration, mast cell degranulation, and albumin leakage, whereas spermine and D-arginine had no effect. These results indicate that NO protects the microvasculature against the deleterious effects of oxidized LDL, an effect that may be related to NO's ability to reduce leukocyte-endothelial cell adhesion and/or prevent mast cell degranulation.

Rapid in situ endothelialization of a small diameter vascular graft with catalytic nitric oxide generation and promoted endothelial cell adhesion

2015 ◽  
Vol 3 (47) ◽  
pp. 9212-9222 ◽  
Author(s):  
Yuanyuan Wang ◽  
Siyuan Chen ◽  
Yiwa Pan ◽  
Jingchen Gao ◽  
Di Tang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cell Adhesion ◽  
Endothelial Cell ◽  
Vascular Graft ◽  
Small Diameter ◽  
Endothelial Cell Adhesion

Rapidin situendothelialization of a small diameter vascular graft with catalytic nitric oxide generation and promoted endothelial cell adhesion.

Role of different nitric oxide synthese (NOS) isoforms in the regulation of endothelial cell adhesion molecule (ECAM) expression in vivo

2000 ◽  
Vol 118 (4) ◽  
pp. A827 ◽  
Author(s):  
Shigeyuki Kawachi ◽  
David J. Leffer ◽  
Henri C. Van Der Heyde ◽  
Stephen Laroux ◽  
Laura Gray ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cell Adhesion ◽  
Endothelial Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Endothelial Cell Adhesion Molecule ◽  
Nos Isoforms ◽  
Endothelial Cell Adhesion

Role of nitric oxide in human pulmonary microvascular endothelial cell adhesion

Life Sciences ◽  
2000 ◽  
Vol 67 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Hirokazu Tsukahara ◽  
Eisei Noiri ◽  
Mi Zu Jiang ◽  
Masahiro Hiraoka ◽  
Mitsufumi Mayumi
Keyword(s):  
Nitric Oxide ◽  
Cell Adhesion ◽  
Endothelial Cell ◽  
Microvascular Endothelial Cell ◽  
Pulmonary Microvascular Endothelial Cell ◽  
Microvascular Endothelial ◽  
Endothelial Cell Adhesion
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