Protective Effects of Ascorbic Acid, dl-α-Tocopherol Acetate, and Sodium Selenate on Ethanol-Induced Liver Damage of Rats

2004 ◽  
Vol 97 (2) ◽  
pp. 149-162 ◽  
Author(s):  
Sadakat Ozdil ◽  
Sehnaz Bolkent ◽  
Refiye Yanardag ◽  
Pelin Arda-Pirincci
Keyword(s):  
Ascorbic Acid ◽  
Liver Damage ◽  
Sodium Selenate ◽  
Protective Effects ◽  
Tocopherol Acetate

scholarly journals Protective effects of Erythronium japonicum and Corylopsis coreana Uyeki extracts against 1,3-dichloro-2-propanol-induced hepatotoxicity in rats

2020 ◽  
Vol 50 (1) ◽  
Author(s):  
Seunghyun Kim ◽  
Hee-Ock Boo ◽  
Taeho Ahn ◽  
Chun-Sik Bae
Keyword(s):  
Liver Damage ◽  
Enzyme Activities ◽  
Oxygen Species ◽  
Protective Effects ◽  
Catalytic Activities ◽  
Anti Oxidant ◽  
Cyp2e1 Activity ◽  
Pre Treatment ◽  
Histopathological Studies ◽  
Erythronium Japonicum

AbstractErythronium japonicum (E. japonicum) and Corylopsis coreana Uyeki (C. coreana Uyeki, Korean winter hazel) have been shown to significantly decrease 1,3-dichloro-2-propanol (1,3-DCP)-induced generation of reactive oxygen species and CYP2E1 activity in HuH7, human hepatocytes. In this study, we expanded upon the previous study and investigated the effects of E. japonicum and C. coreana Uyeki extracts on 1,3-DCP-induced liver damage in rats. The pre-treatment of rats with these extracts alleviated a decrease in body weight and reduced 1,3-DCP-induced increase in catalytic activities of hepatic enzymes, such as aspartate aminotransferase and alanine aminotransferase, in the serum. Moreover, treatment with the extracts restored the 1,3-DCP-induced decreases in anti-oxidant enzyme activities, such as the activities of superoxide dismutase and catalase, in the rat liver. Histopathological studies also strongly supported the results of enzyme activities. These results suggest a possibility that the extracts of E. japonicum and C. coreana Uyeki can be a remedy for alleviating 1,3-DCP-induced liver damage in animals.

scholarly journals Protective effects of Nigella sativa oil against carboplatin-induced liver damage in rats

2019 ◽  
Vol 110 ◽  
pp. 742-747 ◽  
Author(s):  
Zuleyha Erisgin ◽  
Melahat Atasever ◽  
Kadir Cetinkaya ◽  
Saadet Özen Akarca Dizakar ◽  
Suna Omeroglu ◽  
...  
Keyword(s):  
Liver Damage ◽  
Nigella Sativa ◽  
Protective Effects ◽  
Nigella Sativa Oil

scholarly journals The synergistic effect of daidzein and α-tocopherol or ascorbic acid on microsome and LDL oxidation

2010 ◽  
Vol 28 (No. 5) ◽  
pp. 385-391 ◽  
Author(s):  
H. Wang ◽  
M.W. Martin ◽  
S. Yin
Keyword(s):  
Ascorbic Acid ◽  
Antioxidant Properties ◽  
Liver Microsomes ◽  
Oxidative Modification ◽  
Alpha Tocopherol ◽  
Interactive Effects ◽  
Ldl Oxidation ◽  
Rat Liver Microsomes ◽  
Protective Effects ◽  
Potential Health

Isoflavone daidzein brings potential health benefits. Its antioxidant properties are considered to be responsible in part for its protective effects. We investigated the antioxidant effects of daidzein and its interactive effects with<br />&alpha;-tocopherol or ascorbic acid on Fe<sup>2+/</sup>ascorbate-induced oxidation of rat liver microsomes and copper-induced human low-density lipoprotein (LDL) oxidation. Although the inhibitory effect of daidzein on lipid peroxidation in microsome was weak, it effectively prevented LDL against oxidative modification by prolonging the lag time, decreasing the propagating rate, and suppressing malonaldehyde (MDA) and carbonyls formation. When daidzein was combined with &alpha;-tocopherol in microsomes oxidation and with ascorbic acid in LDL oxidation, the protection was significantly greater than the calculated additive effect of the two individual actions. Thus, daidzein can protect LDL from oxidative modification, and its combination with nutrients may be superior to the action of it alone. These results can help to get a better understanding of the interactions of different antioxidants in vivo.

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