scholarly journals Determination of ceruloplasmin, some other acute phase proteins, and biochemical parameters in cows with endometritis

2016 ◽  
Vol 9 (10) ◽  
pp. 1056-1062 ◽  
Author(s):  
S. Kaya ◽  
O. Merhan ◽  
C. Kacar ◽  
A. Colak ◽  
K. Bozukluhan
Keyword(s):  
Acute Phase ◽  
Biochemical Parameters ◽  
Acute Phase Proteins

scholarly journals Effect of flosteron on the content of acute-phase proteins and procalcitonin in infectious arthritis in rats

2021 ◽  
Vol 67 (5) ◽  
pp. 39-43
Author(s):  
S.М. Маgомеdоv ◽  
◽  
Yu.V. Polyachenko ◽  
N.P. Hrystai ◽  
I.G. Lytovka ◽  
...  
Keyword(s):  
Acute Phase ◽  
Inflammatory Process ◽  
Acute Phase Proteins ◽  
White Male ◽  
Infectious Arthritis ◽  
Reactive Protein ◽  
Male Wistar Rats ◽  
Biochemical Analyzer ◽  
Roche Diagnostics

Infectious arthritis was modeled on white male Wistar rats by injecting a suspension of Staphylococcus aureus microorganisms into the knee joint of animals, and the effects of the synthetic hormone flosteron were also studied. At the same time, the content of acute-phase proteins (ceruloplasmin, haptoglobin, C-reactive protein (CRP)) and procalcitonin (PCT) as markers of the development of the inflammatory process and bacterial infection was studied in the blood serum of rats. Determination of the content of haptoglobin, ceruloplasmin and CRP was carried out on a Cobas 311 biochemical analyzer, the PCT concentration on a Cobas 411 analyzer using Roche Diagnostics test systems. Analysis of the results showed that when flosteron was administered, the concentration of CRP increased by 1.7 times already on the 3rd day, and by more than 4 times on the 14th day. The content of ceruloplasmin and haptoglobin also increased. The PCT concentration was at the level of the control values. Under the conditions of modeling infectious arthritis, changes in the content of acutephase proteins were observed. The greatest deviations from the reference values were found on the 14th day in animals that were injected with the hormone and S. aureus: the concentration of both CRP, the most objective biochemical marker of the inflammatory process, and PCT exceeded the physiological norm 12 times and more than 7 times, respectively. This indicates that the hormonal drug enhances the inflammatory process, which is confirmed by data that reflect changes in the content of acute-phase proteins. It can be assumed that the use of hormonal drugs contributes to the development of postoperative complications.

scholarly journals ACUTE PHASE PROTEIN INCREASE IN HIGH ALTITUDE MOUNTAINEERS

2017 ◽  
Vol 23 (6) ◽  
pp. 455-459
Author(s):  
Tolga Saka ◽  
Mehmet Karakus
Keyword(s):  
High Altitude ◽  
Acute Phase ◽  
Biochemical Parameters ◽  
Creatine Phosphokinase ◽  
Acute Phase Proteins ◽  
Acute Phase Protein ◽  
Serum Levels ◽  
Mountain Climbing ◽  
Sedentary Group ◽  
Hematological And Biochemical Parameters

ABSTRACT Introduction: Many middle-aged Turks go hiking in mountains to breathe some fresh air or to maintain fitness. Objective: This study investigated the effects of regular high altitude mountain climbing on the metabolic and hematological responses of mountaineers. Methods: Hematological and biochemical parameters were studied, as well as some hormonal values of 21 mountaineers and 16 healthy age-matched sedentary volunteers. Results: The neutrophil to lymphocyte ratio (NLR) was significantly lower (p<0.04) in mountaineers compared with the sedentary group. Total protein (p<0.001) and albumin (p<0.001) were lower, while the levels of ferritin (p<0.04), creatine (p<0.03) and creatine phosphokinase (p<0.01) were higher in mountaineers. Other hematological and biochemical parameters, i.e., erythrocytes, leukocytes, hemoglobin and hematocrit, did not change significantly. Conclusion: Our results show that regular exposure to high altitude increased the serum levels of some acute phase proteins with anti-inflammatory properties.

scholarly journals Impact of radioiodine treatment on acute phase proteins in hyperthyroid cats

2021 ◽  
pp. 1098612X2110249
Author(s):  
Katharina Glück ◽  
Sabrina Mohrs ◽  
Katarina Hazuchova ◽  
Natali Bauer ◽  
Reto Neiger
Keyword(s):  
Acute Phase ◽  
Acute Phase Proteins ◽  
Fold Increase ◽  
Neoplastic Disease ◽  
Phase Reaction ◽  
Radioiodine Treatment ◽  
Serum Samples ◽  
Amyloid A ◽  
The Impact

Objectives The aim of this study was to investigate the impact of radioiodine treatment (RIT) on the acute phase proteins (APPs) serum amyloid A (SAA), alpha-1-acid glycoprotein (AGP) and haptoglobin (Hp) in hyperthyroid cats. Methods Between June 2013 and November 2014, 33 hyperthyroid cats without clinical or laboratory signs of inflammatory or neoplastic disease and a body weight >2.5 kg were enrolled. Immediately before, and 12, 36, 72 h and 6 days after RIT, serum samples were obtained for determination of APP concentrations. Results Both SAA and AGP concentrations changed significantly after RIT. The concentration of AGP increased gradually after treatment with a maximum concentration at the end of the study period (median baseline 398 μg/ml; median 6 days post-RIT 562 μg/ml [ P = 0.001]). A relevant >two-fold increase in AGP was seen in 8/33 (24%) cats. SAA concentration increased significantly within 12 h (baseline 9.2 μg/ml; 12 h post-RIT 22.5 μg/ml [ P = 0.012]). In 7/33 (21%) cats, a clinically relevant >10-fold increase in SAA was observed. Hp concentration showed no significant change ( P = 0.12). Conclusions and relevance RIT induced a mild, mainly not clinically relevant acute phase reaction (APR). AGP and SAA were useful APPs to determine RIT-induced APR.

The diagnostic value of determination of positive and negative acute phase proteins in milk from dairy cows with subclinical mastitis

2011 ◽  
Vol 21 (5) ◽  
pp. 999-1003 ◽  
Author(s):  
Seyed Hamed Shirazi-Beheshtiha ◽  
Shahabeddin Safi ◽  
Vahid Rabbani ◽  
Mahmoud Bolourchi ◽  
Mehrdad Ameri ◽  
...  
Keyword(s):  
Dairy Cows ◽  
Acute Phase ◽  
Acute Phase Proteins ◽  
Subclinical Mastitis ◽  
Diagnostic Value

Studies on Acute Phase Proteins of Rat Serum. II. Determination of the Contents of α1-Acid Glycoprotein, α2-Macroglobulin, and Albumin in Serum from Rats Suffering from Induced Inflammation

1972 ◽  
Vol 50 (8) ◽  
pp. 871-880 ◽  
Author(s):  
J. C. Jamieson ◽  
F. E. Ashton ◽  
A. D. Friesen ◽  
B. Chou
Keyword(s):  
Acute Phase ◽  
Acute Phase Proteins ◽  
Rat Serum ◽  
Experimental Animals ◽  
Acid Glycoprotein ◽  
Inflammatory Agent ◽  
Glycoprotein Biosynthesis ◽  
Α2 Macroglobulin

A quantitative precipitin technique has been employed to determine the contents of α1-acid glycoprotein, α2-macroglobulin, and albumin in serum from control rats and rats suffering from induced inflammation for 5–96 h. There was an increase in the content of α1-acid glycoprotein and α2-macroglobulin in serum from experimental animals reaching a maximum at 48–72 h after administration of inflammatory agent indicating that both proteins are acute phase globulins. There was only a slight change in the content of albumin in serum from experimental animals when compared with controls. Studies involving incorporation of labelled precursors of glycoprotein biosynthesis into α1-acid glycoprotein and α2-macroglobulin indicated that the most likely explanation for the increase in α1-acid glycoprotein and α2-macroglobulin in serum from experimental animals was an increase in the rates of synthesis of the two proteins in question.

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