scholarly journals ACUTE PHASE PROTEIN INCREASE IN HIGH ALTITUDE MOUNTAINEERS

2017 ◽  
Vol 23 (6) ◽  
pp. 455-459
Author(s):  
Tolga Saka ◽  
Mehmet Karakus
Keyword(s):  
High Altitude ◽  
Acute Phase ◽  
Biochemical Parameters ◽  
Creatine Phosphokinase ◽  
Acute Phase Proteins ◽  
Acute Phase Protein ◽  
Serum Levels ◽  
Mountain Climbing ◽  
Sedentary Group ◽  
Hematological And Biochemical Parameters

ABSTRACT Introduction: Many middle-aged Turks go hiking in mountains to breathe some fresh air or to maintain fitness. Objective: This study investigated the effects of regular high altitude mountain climbing on the metabolic and hematological responses of mountaineers. Methods: Hematological and biochemical parameters were studied, as well as some hormonal values of 21 mountaineers and 16 healthy age-matched sedentary volunteers. Results: The neutrophil to lymphocyte ratio (NLR) was significantly lower (p<0.04) in mountaineers compared with the sedentary group. Total protein (p<0.001) and albumin (p<0.001) were lower, while the levels of ferritin (p<0.04), creatine (p<0.03) and creatine phosphokinase (p<0.01) were higher in mountaineers. Other hematological and biochemical parameters, i.e., erythrocytes, leukocytes, hemoglobin and hematocrit, did not change significantly. Conclusion: Our results show that regular exposure to high altitude increased the serum levels of some acute phase proteins with anti-inflammatory properties.

Major plasma proteins in pig serum during postnatal development

2005 ◽  
Vol 17 (4) ◽  
pp. 439 ◽  
Author(s):  
M. Martin ◽  
M. A. Tesouro ◽  
N. González-Ramón ◽  
A. Piñeiro ◽  
F. Lampreave
Keyword(s):  
Acute Phase ◽  
Plasma Proteins ◽  
Time Course ◽  
Serum Proteins ◽  
Acute Phase Proteins ◽  
Acute Phase Protein ◽  
Serum Levels ◽  
Acid Glycoprotein ◽  
Newborn Pigs ◽  
Low Levels

The time-course of changes in the levels of albumin, α-fetoprotein (AFP), α1-protease inhibitor (α1-antitrypsin), α1-acid glycoprotein, fetuin, haptoglobin, transferrin, IgG and the major acute-phase protein (Pig-MAP) in the blood sera of pigs during the first days and weeks of life was investigated by quantitative radial immunodiffusion. The serum of newborn pigs before suckling was characterised by a very low concentration of total proteins (approximately 25 mg mL–1), low levels of albumin and transferrin and the lack of immunoglobulins. In contrast, α1-acid glycoprotein and fetuin are present at high levels (approximately 12 and 5 mg mL–1 respectively). The results of the present study show that the piglets undergo a very rapid metabolic maturation with regard to serum proteins, evolving from a characteristic ‘fetal’ pattern to an ‘adult’ one. We have paid special attention to the evolution of haptoglobin and Pig-MAP, which are two important acute-phase proteins in pigs. The evolution of serum levels of these proteins suggests that piglets must overcome a moderate acute-phase situation during the first week of life.

Serum amyloid A protein (SAA), haptoglobin (Hp) and selected hematological and biochemical parameters in wild mares before and after parturition

2017 ◽  
Vol 20 (2) ◽  
pp. 299-305 ◽  
Author(s):  
L. Krakowski ◽  
P. Bartoszek ◽  
I. Krakowska ◽  
P. Olcha ◽  
T. Piech ◽  
...  
Keyword(s):  
Acute Phase ◽  
Biochemical Parameters ◽  
Acute Phase Proteins ◽  
Perinatal Period ◽  
Serum Concentrations ◽  
Amyloid A ◽  
Group I ◽  
Significant Difference ◽  
Group Ii ◽  
Hematological And Biochemical Parameters

Abstract The aim of the study was to evaluate physiological changes in hematological and biochemical parameters in mares in perinatal period. Blood samples were collected from 24 pregnant Polish Konik breed mares which were divided into two groups. The first group (Group – I, n=12) comprised mares living in the wild, in the reserve. The second group (Group – II, n=12) consisted of mares kept in stables. The blood was collected 2 weeks prior to the parturition, then 24 hours after the delivery, and then at the 7th and 21st day after foaling. When comparing the two groups before the parturition, no significant differences in terms of WBC, RBC, and Hb were found, however, there was a significant difference in MCV, MCH, LYM, NEU and SEG NEU (p≤0.05). In Group II, 24 hours after the parturition and at the 21st day after foaling, a significant raise in WBC, NEU and SEG NEU (p≤0.05) was detected. No significant differences in serum concentrations of proteins such as TP, Alb or Glb were observed. As to acute phase proteins, significant rise in SAA and Hp (p≤0.05) was found in the two examined groups 24 hours after the parturition. Yet, this rise remained within physiological range. The study revealed a certain degree of fluctuations in hematological parameters, in serum concentrations of acute-phase proteins and total proteins in the mares in the perinatal period. However, these changes remained still within physiological ranges and thus they do not indicate potential susceptibility to disorders of perinatal period.

Acute Phase Proteins and Interleukin?6 Serum Levels in Patients with Chronic Arterial Occlusion

2006 ◽  
Vol 762 (1) ◽  
pp. 493-495 ◽  
Author(s):  
WACLAW MAJEWSKI ◽  
RYSZARD STANISZEWSKI ◽  
ARTUR SLUPIANEK ◽  
ALEKSANDER GORNY ◽  
ANDRZEJ MACKIEWICZ
Keyword(s):  
Acute Phase ◽  
Interleukin 6 ◽  
Acute Phase Proteins ◽  
Arterial Occlusion ◽  
Serum Levels ◽  
Chronic Arterial Occlusion

scholarly journals Determination of ceruloplasmin, some other acute phase proteins, and biochemical parameters in cows with endometritis

2016 ◽  
Vol 9 (10) ◽  
pp. 1056-1062 ◽  
Author(s):  
S. Kaya ◽  
O. Merhan ◽  
C. Kacar ◽  
A. Colak ◽  
K. Bozukluhan
Keyword(s):  
Acute Phase ◽  
Biochemical Parameters ◽  
Acute Phase Proteins

Abstract 1629: Genetic Polymorphism A1675G On Angiotensin Receptor Type 2, Is Implicated In The Expression Of Acute Phase Proteins And The Development Of Coronary Atherosclerosis In Hypertensive Patients

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Dimitris Tousoulis ◽  
Nikolas Koumallos ◽  
Charalambos Antoniades ◽  
Despina Kardara ◽  
Alexis S Antonopoulos ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Arterial Hypertension ◽  
Acute Phase ◽  
Coronary Atherosclerosis ◽  
Acute Phase Proteins ◽  
Renin Angiotensin System ◽  
Serum Levels ◽  
Hypertensive Patients ◽  
The Impact

Introduction: Renin-angiotensin system affects cardiovascular disease pathogenesis through a balance of angiotensin II effects on proatherogenic constitutive type 1 and antiatherogenic inducible type 2 (AT2R) receptors. The impact of A1675G polymorphism on the development of hypertension and advanced atherosclerosis is controversial. We examined the impact of A1675G polymorphism on AT2R, on the risk for arterial hypertension and coronary atherosclerosis, and its effect on the expression of proatherogenic inflammatory molecules. Methods. The study population consisted of 310 males: 145 with arterial hypertension and 165 controls, matched for age and risk factors for atherosclerosis. Among hypertensive subjects, 37 had angiographically documented coronary atherosclerosis and 108 had no evidence of atherosclerosis. The presence of A1675G polymorphism on AT2R gene (located in chromosome X) was determined by PCR. Serum levels of C-reactive protein and fibrinogen was measured in all the participants. Results. The frequency of the A allele was similar between patients with arterial hypertension (64/145, 44.1%) and non-hypertensive subjects (73/165, 44.2%, p=NS), while the risk for arterial hypertension was OR[95%CI]:1.004[0.641–1.574], p=0.985 for the G vs A carriers. However, the risk for coronary atherosclerosis within the group of hypertensive subjects was significantly elevated in the carriers of the A allele (OR[95%CI]:2.128[1.003–4.513], p=0.04 vs carriers of the G allele). Importantly, the presence of the A allele was also associated with significantly higher levels of CRP (4.8±0.8mg/dl) compared to the carriers of the G allele (3.0±0.3mg/dl, p<0.05). Similarly, fibrinogen levels were higher in A-allele carriers (median(25 th –75th percentile) 395(340 – 455) mg/ml) compared to G-allele carriers (369(320 – 406) mg/ml, p<0.05). Conclusions: Although genetic polymorphism A1675G on AT2R is not associated with the development of arterial hypertension, it affects the risk for coronary artery disease among hypertensive patients. The presence of the A allele also leads to higher levels of CRP and fibrinogen, implying that this polymorphism may induce atherogenesis by modulating acute phase response in hypertensive individuals.

scholarly journals Serum levels of proteins and acute-phase proteins in captive emus ( Dromaius novaehllandieae ) of different ages

2017 ◽  
Vol 69 (2) ◽  
pp. 405-408
Author(s):  
P.A. Di Filippo ◽  
I.S. Viana ◽  
A.J. Almeida ◽  
F.A.S. Graça ◽  
A.B.F. Rodrigues ◽  
...  
Keyword(s):  
Acute Phase ◽  
Simple Technique ◽  
Acute Phase Proteins ◽  
Protein Profile ◽  
Serum Levels ◽  
Protein Electrophoresis ◽  
Sds Page ◽  
Dromaius Novaehollandiae ◽  
Diagnosis Of Diseases

ABSTRACT Protein electrophoresis is a relatively simple technique that allows separating serum protein fractions, and provides important information in the investigation and diagnosis of several diseases. This study determined the levels of acute-phase proteins in the serum of healthy, captive emus (Dromaius novaehollandiae). Animals were divided into two groups (n=11 in each) based on age, with 1-year-old and 4-year-old emus. Acute-phase proteins were separated by SDS-PAGE. Ceruloplasmin, transferrin, albumin, haptoglobin, acidic glycoprotein, IgA, and IgG were detected in the serum of all animals. Protein profiles varied significantly with age (P<0.05). Individuals in the 4-year-old emus group had higher values of ceruloplasmin, transferrin, albumin, haptoglobin, and acidic glycoprotein, compared with the group with 1-year-old animals, showing the role of age in the protein profile of this species. Reference values for acute-phase proteins in healthy emus may be useful in the evaluation of health status and in the diagnosis of diseases affecting the species.

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