scholarly journals Black soybean tempeh and purple sweet potato improve sperm quality in streptozotocin-induced diabetic rats

2020 ◽  
Vol 13 (11) ◽  
pp. 2534-2540
Author(s):  
Abdul Gofur ◽  
Agung Witjoro ◽  
Siti Nur Arifah ◽  
Mochammad Fitri Atho'illah ◽  
Yuslinda Annisa ◽  
...  
Keyword(s):  
Sweet Potato ◽  
Sperm Quality ◽  
Diabetic Rats ◽  
High Fat ◽  
Advanced Glycation ◽  
Black Soybean ◽  
High Fat Diets ◽  
Purple Sweet Potato ◽  
Fat Diets ◽  
Rage Expression

Background and Aim: Hyperglycemia increases advanced glycation end-product (AGE) production, and the activity of receptor for AGE (RAGE) in testis, which leads to testicular histopathological damage and infertility. This research investigated the effect of black soybean tempeh (BST), purple sweet potato (PSP), and its combination on AGE and RAGE expression and spermatozoa quality in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: The rats were given high-fat diets for 5 weeks, then were injected intraperitoneally with multiple low doses of STZ (30 mg/kg body weight). Diabetes mellitus (DM) rats were divided into seven groups: DM, DM+glibenclamide, DM+BST, DM+PSP, and DM+combination of BST and PSP in ratio 1:3, 2:2, and 3:1 as C1, C2, and C3, respectively. The rats were treated for 30 days. Testicular AGE and RAGE expression and spermatozoa quality were measured. Results: The combination of BST and PSP significantly decreased AGE and RAGE expression in testicular organs and improved spermatozoa quality compared to the normal group. Conclusion: The combination of BST and PSP can be used as future alternatives to improve spermatozoa quality in DM patients.

The Evaluation of Dietary Black Soybean and Purple Sweet Potato on Insulin Sensitivity in Streptozotocin - Induced Diabetic Rats

2019 ◽  
Vol 11 (4) ◽  
pp. 639-646 ◽  
Author(s):  
Abdul Gofur ◽  
Agung Witjoro ◽  
Erni Widya Ningtiyas ◽  
Evi Setyowati ◽  
Siti Aminatul Mukharromah ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Sweet Potato ◽  
Diabetic Rats ◽  
Black Soybean ◽  
Purple Sweet Potato

Maternal and postnatal high-fat diets with high ω6 : ω3 ratios affect the reproductive performance of male offspring in the mouse

2018 ◽  
Vol 30 (11) ◽  
pp. 1491
Author(s):  
S. Bianconi ◽  
G. Stutz ◽  
M. R. Solís ◽  
A. C. Martini ◽  
L. M. Vincenti ◽  
...  
Keyword(s):  
Reproductive Performance ◽  
Sperm Quality ◽  
Membrane Integrity ◽  
Unsaturation Index ◽  
High Fat ◽  
Commercial Diet ◽  
Fertilisation Rate ◽  
Testicular Weight ◽  
High Fat Diets ◽  
Fat Diets

High-fat diets (HFDs) are an acknowledged risk factor for male subfertility, but the underlying mechanisms remain unclear. In the present study we compared the effects of two HFDs with different ω6 : ω3 ratios, one enriched with soy oil (SOD; ω6 : ω3 = 9.62) and another enriched with sunflower oil (SFOD; ω6 : ω3 = 51.55), with those of a commercial diet (CD; ω6 : ω3 = 19.87), supplied from pregnancy to adulthood, on morphometric parameters and reproductive performance in adult male mice (recommended ω6 : ω3 for rodents = 1–6). Bodyweight was significantly higher in the SFOD than CD group, and relative testicular weight was significantly lower in the SFOD than the other two groups. SFOD altered sperm performance: it reduced sperm viability (mean ± s.e.m.; 76.00 ± 1.35% vs 82.50 ± 1.45% and 80.63 ± 1.00% in the SFOD vs CD and SOD groups respectively; P < 0.05) and increased the percentage of immature spermatozoa (71.88 ± 7.17% vs 51.38 ± 5.87% and 48.00 ± 5.72% in the SFOD vs CD and SOD groups respectively; P < 0.05). The epididymal ω6 : ω3 ratio was higher in the SFOD versus CD and SOD groups, whereas the unsaturation index was higher in the SOD and SFOD groups than in CD group. Sperm membrane integrity was diminished in both the SOD and SFOD groups, but there was no difference in sperm reactive oxygen species production in these two groups compared with the CD group. The fertilisation rate was lower in the SFOD compared with the CD and SOD groups. In conclusion, although both HFDs affected sperm quality, the fertilising ability was more altered by the excessive dietary ω6 : ω3 ratio than by the net ω6 content.

Barley malt increases hindgut and portal butyric acid, modulates gene expression of gut tight junction proteins and Toll-like receptors in rats fed high-fat diets, but high advanced glycation end-products partially attenuate the effects

2015 ◽  
Vol 6 (9) ◽  
pp. 3165-3176 ◽  
Author(s):  
Yadong Zhong ◽  
Cristina Teixeira ◽  
Nittaya Marungruang ◽  
Watina Sae-Lim ◽  
Eden Tareke ◽  
...  
Keyword(s):  
Butyric Acid ◽  
Tight Junction Proteins ◽  
High Fat ◽  
Advanced Glycation ◽  
Barley Malt ◽  
Glycation End Products ◽  
High Fat Diets ◽  
End Products ◽  
Fat Diets ◽  
Junction Proteins

Barley malt has been shown to give high levels of butyric acid in the cecum and serum of rats.

Non-Fasting Factor VII Coagulant Activity (FVII:C) Increased by High-Fat Diet

1994 ◽  
Vol 71 (06) ◽  
pp. 755-758 ◽  
Author(s):  
E M Bladbjerg ◽  
P Marckmann ◽  
B Sandström ◽  
J Jespersen
Keyword(s):  
High Fat Diet ◽  
Fat Content ◽  
Factor Vii ◽  
Amidolytic Activity ◽  
High Fat ◽  
Low Fat Diet ◽  
Increased Risk ◽  
Coagulant Activity ◽  
High Fat Diets ◽  
Fat Diets

SummaryPreliminary observations have suggested that non-fasting factor VII coagulant activity (FVII:C) may be related to the dietary fat content. To confirm this, we performed a randomised cross-over study. Seventeen young volunteers were served 2 controlled isoenergetic diets differing in fat content (20% or 50% of energy). The 2 diets were served on 2 consecutive days. Blood samples were collected at 8.00 h, 16.30 h and 19.30 h, and analysed for triglycerides, FVII coagulant activity using human (FVII:C) or bovine thromboplastin (FVII:Bt), and FVII amidolytic activity (FVIPAm). The ratio FVII:Bt/FVII:Am (a measure of FVII activation) increased from fasting levels on both diets, but most markedly on the high-fat diet. In contrast, FVII: Am (a measure of FVII protein) tended to decrease from fasting levels on both diets. FVII:C rose from fasting levels on the high-fat diet, but not on the low-fat diet. The findings suggest that high-fat diets increase non-fasting FVII:C, and consequently may be associated with increased risk of thrombosis.

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