scholarly journals Antibody Response of Buffalo Calves to Different Levels of Foot and Mouth Disease Virus Immunogen

2021 ◽  
pp. 466-471
Author(s):  
Qaiser Akram ◽  
Shahid Hussain Farooqi ◽  
Hafiz Muhammad Rizwan ◽  
Beenish Zahid ◽  
Muhammad Ahsan Naeem ◽  
...  
Keyword(s):  
Antibody Response ◽  
Antibody Titer ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Buffalo Calves ◽  
Fmd Virus ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth ◽  
Different Levels

Antibody response of buffalo calves to different levels of Foot and Mouth Disease (FMD) virus immunogen was investigated. Vaccine containing 106.2 units of immunogen/TCID50 of FMD virus (O, A and Asia-1) serotypes induced log2 (1.3± 0.4) units of anti-FMD O Complement Fixing Geometric Mean antibody (FMD O CFT-CGM) titer, log2 (1.4±0.3) units of anti-FMD A CFT-CGM titer and log2 (2.0±0.7) units of anti-FMD Asia-1 CFT-CGM titer. The vaccine containing 2x106.2 units of immunogen of each of the virus serotypes induced log2 (2.2±0.2) units of anti- FMD O CFT-CGM titer, log2 (2.1±0.25) units of anti- FMD A CFT-CGM titer and log2 (3.4±0.8) units of anti-FMD Asia-1 CFT-CGM titer. The vaccine containing 3x106.2 units of TCID50 of each of the virus serotypes induced log2 (5.3 ± 2.0) units of anti-FMD O CFT-CGM titer, log2 (4.6±1.9) units of anti-FMD A CFT-CGM titer and log2 (5.0±2.2) units of anti- FMD Asia-1 CFT-CGM titer. Moreover, buffalo calves (n=3) which were primed and boosted with 60 days interval using vaccine containing 2x106.2 units of immunogen of each of the virus serotype, showed log25.0 and log26.3 units of anti FMD O CFT-GMT antibody titer, log24.6 and log26.0 units of anti FMD A CFT GMT antibody titer, log25.6 and log26.0 units of anti FMD Asia-1 CFT GMT antibody titer, on 30 and 120 days post boosting. Antibody response of buffalo calves was directly proportional to amount of FMD virus immunogen serotypes in the vaccine. 

Antiviral potential of ivermectin against foot-and-mouth disease virus, serotype O, A and Asia-1

2021 ◽  
pp. 104914
Author(s):  
Zahra Naeem ◽  
Sohail Raza ◽  
Saba Afzal ◽  
Ali Ahmad Sheikh ◽  
Muhammad Muddassir Ali ◽  
...  
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Serotype O ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth

A recombinant protein-based ELISA for detecting antibodies to foot-and-mouth disease virus serotype Asia 1

2009 ◽  
Vol 159 (1) ◽  
pp. 112-118 ◽  
Author(s):  
Young-Joon Ko ◽  
Hye-Young Jeoung ◽  
Hyang-Sim Lee ◽  
Byung-Sik Chang ◽  
Seung-Min Hong ◽  
...  
Keyword(s):  
Recombinant Protein ◽  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth ◽  
Serotype Asia 1

Evidence of recombination in a new isolate of foot-and-mouth disease virus serotype Asia 1

2009 ◽  
Vol 139 (1) ◽  
pp. 117-121 ◽  
Author(s):  
Kwang-Nyeong Lee ◽  
Jae-Ku Oem ◽  
Jong-Hyeon Park ◽  
Su-Mi Kim ◽  
Seo-Yong Lee ◽  
...  
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth ◽  
Serotype Asia 1

scholarly journals Analysis of Amino Acid Mutations of the Foot-and-Mouth Disease Virus Serotype O Using both Heparan Sulfate and JMJD6 Receptors

Viruses ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 1012 ◽  
Author(s):  
Gyeongmin Lee ◽  
Ji-Hyeon Hwang ◽  
Aro Kim ◽  
Jong-Hyeon Park ◽  
Min Ja Lee ◽  
...  
Keyword(s):  
Amino Acid ◽  
Heparan Sulfate ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Amino Acid Sequences ◽  
Cell Adaptation ◽  
Field Virus ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth

Foot-and-mouth disease (FMD) is an economically devastating animal disease. Adapting the field virus to cells is critical to the vaccine production of FMD viruses (FMDV), and heparan sulfate (HS) and Jumonji C-domain-containing protein 6 (JMJD6) are alternative receptors of cell-adapted FMDV. We performed serial passages of FMDV O/SKR/Andong/2010, classified as the O/Mya-98 topotype/lineage and known as a highly virulent strain, to develop a vaccine seed virus. We traced changes in the amino acid sequences of the P1 region, plaque phenotypes, and the receptor usage of the viruses, and then structurally analyzed the mutations. VP3 H56R and D60G mutations were observed in viruses using the HS receptor and led to changes in the hydrogen bonding between VP3 56 and 60. A VP1 P208L mutation was observed in the virus using the JMJD6 receptor during cell adaptation, enabling the interaction with JMJD6 through the formation of a new hydrogen bond with JMJD6 residue 300. Furthermore, VP1 208 was near the VP1 95/96 amino acids, previously reported as critical mutations for JMJD6 receptor interactions. Thus, the mutation at VP1 208 could be critical for cell adaptation related to the JMJD6 receptor and may serve as a basis for mechanism studies on FMDV cell adaptation.

scholarly journals Hemato-Biochemical studies on Egyptian Buffaloes and Calves naturally infected with Foot and Mouth Disease Virus serotype SAT 2

2016 ◽  
Vol 73 (2) ◽  
pp. 230
Author(s):  
Essam A Mahmoud ◽  
Ahmed N.F Neamat-allah
Keyword(s):  
Clinical Signs ◽  
Foot And Mouth Disease ◽  
Viral Disease ◽  
Mouth Disease ◽  
Cardiac Markers ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth ◽  
Infected Adult ◽  
Apparently Healthy

Foot and mouth disease (FMD) is a highly contagious viral disease of all cloven footed domestic and wild animals. This work was planned to study the different markers for diagnosis of FMDV serotype Sat2 in adult buffaloes and calves including clinical, hematological and biochemical examinations. A total number of sixty animals were divided into four groups. The first group was apparently healthy adult buffaloes, while the second was naturally infected adult buffaloes, a third group was apparently healthy suckling calves and finally the fourth group was naturally infected suckling calves. The recorded clinical signs were fever, salivation, loss of appetite, depression, lameness, blisters or vesicles, erosions and ulcers in the mucosa of the mouth, tongue, lips, gums, pharynx, palate and between the claws. Anemia, leucopenia, lymphopenia and monocytopenia were recorded in infected adult buffaloes and calves. Myocardial injury proved by presence of degenerated myocardial fibers and lymphocyte cell infiltration with a significant increase in cardiac markers like cardiac torponin I, CPK and LDH in addition to a significant hyperkalemia, hypocalcaemia and hypomagnesemia in buffaloe calves. Moreover, electrophoresis showed hyoproteinemia, hypoalbuminemia and hypoglobulinemia in infected animals. It could be concluded that the elevation of cardiac markers emphasized that FMD is more severe in young calves than adult animals. Therefore, it is recommended to evaluate the prognosis of FMD infection in calves by these markers.

scholarly journals Emergence of novel lineage of foot‐and‐mouth disease virus serotype Asia1 BD‐18 (G‐IX) in Bangladesh

2019 ◽  
Vol 67 (2) ◽  
pp. 486-493 ◽  
Author(s):  
M. Rahmat Ali ◽  
A. S. M. Rubayet Ul Alam ◽  
Md. Al Amin ◽  
Mohammad Anwar Siddique ◽  
Munawar Sultana ◽  
...  
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth
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