scholarly journals PINK1 Deficiency Aggravates the β-amyloid-attenuated Mitophagy-lysosomal Degradation in PC12 Cells

2022 ◽  
Vol 000 (000) ◽  
pp. 000-000
Author(s):  
Xiao-Juan Wang ◽  
Yong-Qiang Xue ◽  
He-Ling Zhang ◽  
Ying Yu ◽  
Peng Liu
Keyword(s):  
Pc12 Cells ◽  
Lysosomal Degradation ◽  
Β Amyloid

scholarly journals Adlay hull extracts attenuate β-amyloid-induced neurotoxicity and oxidative stress in PC12 cells through antioxidative, anti-inflammatory, and antiapoptotic activities

2021 ◽  
Vol 26 ◽  
pp. 101020
Author(s):  
Gregory J. Tsay ◽  
Yu-Ta Lin ◽  
Chia-Hong Hsu ◽  
Feng-Yao Tang ◽  
Yueh-Hsiung Kuo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pc12 Cells ◽  
Β Amyloid ◽  
Anti Inflammatory ◽  
And Oxidative Stress

Sulfated glycosaminoglycans and dyes attenuate the neurotoxic effects of β-amyloid in rat PC12 cells

1995 ◽  
Vol 184 (2) ◽  
pp. 113-116 ◽  
Author(s):  
Scott J. Pollack ◽  
Isobel I.J. Sadler ◽  
Stuart R. Hawtin ◽  
Vipula J. Tailor ◽  
Mark S. Shearman
Keyword(s):  
Pc12 Cells ◽  
Neurotoxic Effects ◽  
Β Amyloid

The microbial alkaloid toxin staurosporine blocks the phorbol ester-induced increase in β-amyloid precursor protein in PC12 cells

1998 ◽  
Vol 5 (5) ◽  
pp. 173-179 ◽  
Author(s):  
Lilach Mira Friedman ◽  
Yuzuru Matsuda ◽  
Philip Lazarovici
Keyword(s):  
Amyloid Precursor Protein ◽  
Pc12 Cells ◽  
Phorbol Ester ◽  
Precursor Protein ◽  
Β Amyloid

scholarly journals Resveratrol inhibits β-amyloid-induced neuronal apoptosis via regulation of p53 acetylation in PC12 cells

2014 ◽  
Vol 11 (4) ◽  
pp. 2429-2434 ◽  
Author(s):  
ZHIBING AI ◽  
CHENGYAN LI ◽  
LONGTI LI ◽  
GUOHOU HE
Keyword(s):  
Pc12 Cells ◽  
Neuronal Apoptosis ◽  
Β Amyloid

Lipophilic ferulic acid derivatives protect PC12 cells against oxidative damage via modulating β-amyloid aggregation and activating Nrf2 enzymes

2020 ◽  
Vol 11 (5) ◽  
pp. 4707-4718 ◽  
Author(s):  
Yu Wu ◽  
Yu-gang Shi ◽  
Xiao-liang Zheng ◽  
Ya-li Dang ◽  
Chen-min Zhu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Oxidative Damage ◽  
Ferulic Acid ◽  
Pc12 Cells ◽  
Amyloid Beta ◽  
Neuroprotective Effect ◽  
Amyloid Aggregation ◽  
Β Amyloid

Ferulic acid (FA) has been shown to have a neuroprotective effect on Alzheimer's disease induced by amyloid-beta (Aβ) neurotoxicity.

scholarly journals Design and Synthesis of New Benzo[d]oxazole-Based Derivatives and Their Neuroprotective Effects on β-Amyloid-Induced PC12 Cells

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5391
Author(s):  
Zheng Liu ◽  
Ming Bian ◽  
Qian-Qian Ma ◽  
Zhuo Zhang ◽  
Huan-Huan Du ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Glycogen Synthase ◽  
B Cell Lymphoma ◽  
Nuclear Factor Κb ◽  
In Vivo Studies ◽  
Neuroprotective Effects ◽  
Β Amyloid ◽  
Gsk 3Β

A series of novel synthetic substituted benzo[d]oxazole-based derivatives (5a–5v) exerted neuroprotective effects on β-amyloid (Aβ)-induced PC12 cells as a potential approach for the treatment of Alzheimer’s disease (AD). In vitro studies show that most of the synthesized compounds were potent in reducing the neurotoxicity of Aβ25-35-induced PC12 cells at 5 μg/mL. We found that compound 5c was non-neurotoxic at 30 μg/mL and significantly increased the viability of Aβ25-35-induced PC12 cells at 1.25, 2.5 and 5 μg/mL. Western blot analysis showed that compound 5c promoted the phosphorylation of Akt and glycogen synthase kinase (GSK-3β) and decreased the expression of nuclear factor-κB (NF-κB) in Aβ25-35-induced PC12 cells. In addition, our findings demonstrated that compound 5c protected PC12 cells from Aβ25-35-induced apoptosis and reduced the hyperphosphorylation of tau protein, and decreased the expression of receptor for AGE (RAGE), β-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1), inducible nitric oxide synthase (iNOS) and Bcl-2-associated X protein/B-cell lymphoma 2 (Bax/Bcl-2) via Akt/GSK-3β/NF-κB signaling pathway. In vivo studies suggest that compound 5c shows less toxicity than donepezil in the heart and nervous system of zebrafish.

s-Ethyl Cysteine ands-Propyl Cysteine Alleviate β-Amyloid Induced Cytotoxicity in Nerve Growth Factor Differentiated PC12 Cells

2010 ◽  
Vol 58 (11) ◽  
pp. 7104-7108 ◽  
Author(s):  
Shih-Jei Tsai ◽  
Chia-Yu Lin ◽  
Mei-Chin Mong ◽  
Mao-Wang Ho ◽  
Mei-Chin Yin
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Pc12 Cells ◽  
Nerve Growth ◽  
Differentiated Pc12 Cells ◽  
Β Amyloid

The marijuana component cannabidiol inhibits β-amyloid-induced tau protein hyperphosphorylation through Wnt/β-catenin pathway rescue in PC12 cells

2005 ◽  
Vol 84 (3) ◽  
pp. 253-258 ◽  
Author(s):  
Giuseppe Esposito ◽  
Daniele De Filippis ◽  
Rosa Carnuccio ◽  
Angelo A. Izzo ◽  
Teresa Iuvone
Keyword(s):  
Pc12 Cells ◽  
Tau Protein ◽  
Β Amyloid

Protective Effects of Pinostrobin on β-Amyloid-Induced Neurotoxicity in PC12 Cells

2012 ◽  
Vol 32 (8) ◽  
pp. 1223-1230 ◽  
Author(s):  
Yan-Fang Xian ◽  
Siu-Po Ip ◽  
Zhi-Xiu Lin ◽  
Qing-Qiu Mao ◽  
Zi-Ren Su ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Protective Effects ◽  
Β Amyloid

Acute application of human amylin, unlike β-amyloid peptides, kills undifferentiated PC12 cells by apoptosis

Neuroreport ◽  
1997 ◽  
Vol 8 (18) ◽  
pp. 3945-3949 ◽  
Author(s):  
Geraldine A. MacGibbon ◽  
Garth J.S. Cooper ◽  
Michael Dragunow
Keyword(s):  
Pc12 Cells ◽  
Amyloid Peptides ◽  
Β Amyloid ◽  
Human Amylin
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