Protective Effects of Pinostrobin on β-Amyloid-Induced Neurotoxicity in PC12 Cells

2012 ◽  
Vol 32 (8) ◽  
pp. 1223-1230 ◽  
Author(s):  
Yan-Fang Xian ◽  
Siu-Po Ip ◽  
Zhi-Xiu Lin ◽  
Qing-Qiu Mao ◽  
Zi-Ren Su ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Protective Effects ◽  
Β Amyloid

Protective Effects of Hydroxysafflor Yellow A on β-Amyloid-Induced Neurotoxicity in PC12 Cells

2013 ◽  
Vol 38 (5) ◽  
pp. 951-960 ◽  
Author(s):  
Song-Zhi Kong ◽  
Yan-Fang Xian ◽  
Siu-Po Ip ◽  
Xiao-Ping Lai ◽  
Xu-Guang Shi ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Protective Effects ◽  
Hydroxysafflor Yellow A ◽  
Β Amyloid

Protective effects of silk lutein extract from Bombyx mori cocoons on β-Amyloid peptide-induced　apoptosis in PC12 cells

2018 ◽  
Vol 103 ◽  
pp. 582-587 ◽  
Author(s):  
Nongnuch Singhrang ◽  
Chainarong Tocharus ◽  
Sarinthorn Thummayot ◽  
Manote Sutheerawattananonda ◽  
Jiraporn Tocharus
Keyword(s):  
Bombyx Mori ◽  
Pc12 Cells ◽  
Amyloid Peptide ◽  
Protective Effects ◽  
Β Amyloid ◽  
Β Amyloid Peptide ◽  
Induced Apoptosis

scholarly journals Both estrogen and raloxifene protect against β-amyloid-induced neurotoxicity in estrogen receptor α-transfected PC12 cells by activation of telomerase activity via Akt cascade

2004 ◽  
Vol 183 (3) ◽  
pp. 605-615 ◽  
Author(s):  
Botao Du ◽  
Masahide Ohmichi ◽  
Kazuhiro Takahashi ◽  
Jun Kawagoe ◽  
Chika Ohshima ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Pc12 Cells ◽  
Kinase Inhibitor ◽  
Phosphorylation Site ◽  
Telomerase Activity ◽  
Transcriptional Level ◽  
Control Line ◽  
Protective Effects ◽  
Neuroprotective Effects ◽  
Β Amyloid

Although estrogen is known to protect against β-amyloid (Aβ)-induced neurotoxicity, the mechanisms responsible for this effect are only beginning to be elucidated. In addition, the effect of raloxifene on Aβ-induced neuro-toxicity remains unknown. Here we investigated whether raloxifene exhibits similar neuro-protective effects to estrogen against Aβ-induced neurotoxicity and the mechanism of the effects of these agents in PC12 cells transfected with the full-length human estrogen receptor (ER) α gene (PCER). Raloxifene, like 17β-estradiol (E2), significantly inhibited Aβ-induced apoptosis in PCER cells, but not in a control line of cells transfected with vector DNA alone (PCCON). Since telomerase activity, the level of which is modulated by regulation of telomerase catalytic subunit (TERT) at both the transcriptional and post-transcriptional levels, is known to be involved in suppressing apoptosis in neurons, we examined the effect of E2 and raloxifene on telomerase activity. Although both E2 and raloxifene induced telomerase activity in PCER cells, but not in PCCON cells, treated with Aβ, they had no effect on the level of TERT expression. These results suggest that neither E2 nor raloxifene affects the telomerase activity at the transcriptional level. We therefore studied the mechanism by which E2 and raloxifene induce the telomerase activity at the post-transcriptional level. Both E2 and raloxifene induced the phosphorylation of Akt, and pre-treatment with a phosphatidylinositol 3-kinase inhibitor, LY294002, attenuated both E2− and raloxifene-induced activation of the telomerase activity. Moreover, both E2 and raloxifene induced both the phosphorylation of TERT at a putative Akt phosphorylation site and the association of nuclear factor κB with TERT. Our findings suggest that and raloxifene exert neuroprotective effects by E2 telomerase activation via a post-transcriptional cascade in an experimental model relevant to Alzheimer’s disease.

scholarly journals Protective Effects of the Key Compounds Isolated from Corni fructus against β-Amyloid-Induced Neurotoxicity in PC12 Cells

Molecules ◽  
2012 ◽  
Vol 17 (9) ◽  
pp. 10831-10845 ◽  
Author(s):  
Seung-Young Hong ◽  
Woo-Sik Jeong ◽  
Mira Jun
Keyword(s):  
Pc12 Cells ◽  
Protective Effects ◽  
Β Amyloid ◽  
Corni Fructus

The Protective Effects of Jatrorrhizine on β-Amyloid (25-35)-Induced Neurotoxicity in Rat Cortical Neurons

2013 ◽  
Vol 11 (8) ◽  
pp. 1030-1037 ◽  
Author(s):  
Tao Luo ◽  
Wei Jiang ◽  
Yan Kong ◽  
Sheng Li ◽  
Feng He ◽  
...  
Keyword(s):  
Cortical Neurons ◽  
Protective Effects ◽  
Rat Cortical Neurons ◽  
Β Amyloid

scholarly journals Protective Effect of Psoralea corylifolia L. Seed Extract against Palmitate-Induced Neuronal Apoptosis in PC12 Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Yunkyoung Lee ◽  
Hee-Sook Jun ◽  
Yoon Sin Oh
Keyword(s):  
Pc12 Cells ◽  
Molecular Mechanisms ◽  
Neuronal Cell ◽  
Marker Genes ◽  
Heme Oxygenase 1 ◽  
Mrna Levels ◽  
Protective Effects ◽  
Psoralea Corylifolia ◽  
Antioxidant Genes ◽  
Bax Protein

The extract of Psoralea corylifolia seeds (PCE) has been widely used as a herbal medicine because of its beneficial effect on human health. In this study, we investigated the protective effects and molecular mechanisms of PCE on palmitate- (PA-) induced toxicity in PC12 cells, a neuron-like cell line. PCE significantly increased cell viability in PA-treated PC12 cells and showed antiapoptotic effects, as evidenced by decreased expression of cleaved caspase-3, cleaved poly(ADP-ribose) polymerase, and bax protein as well as increased expression of bcl-2 protein. In addition, PCE treatment reduced PA-induced reactive oxygen species production and upregulated mRNA levels of antioxidant genes such as nuclear factor (erythroid-derived 2)-like 2 and heme oxygenase 1. Moreover, PCE treatment recovered the expression of autophagy marker genes such as beclin-1 and p62, which was decreased by PA treatment. Treatment with isopsoralen, one of the major components of PCE extract, also recovered the expression of autophagy marker genes and reduced PA-induced apoptosis. In conclusion, PCE exerts protective effects against lipotoxicity via its antioxidant function, and this effect is mediated by activation of autophagy. PCE might be a potential pharmacological agent to protect against neuronal cell injury caused by oxidative stress or lipotoxicity.

scholarly journals Adlay hull extracts attenuate β-amyloid-induced neurotoxicity and oxidative stress in PC12 cells through antioxidative, anti-inflammatory, and antiapoptotic activities

2021 ◽  
Vol 26 ◽  
pp. 101020
Author(s):  
Gregory J. Tsay ◽  
Yu-Ta Lin ◽  
Chia-Hong Hsu ◽  
Feng-Yao Tang ◽  
Yueh-Hsiung Kuo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pc12 Cells ◽  
Β Amyloid ◽  
Anti Inflammatory ◽  
And Oxidative Stress
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