scholarly journals Role of Sox trio, Nfi and Hmgb1 factors in the unique transcriptional regulatory mechanisms of the matrilin-1 gene

2014 ◽  
Author(s):  
Tibor Szénási
Keyword(s):  
Regulatory Mechanisms ◽  
Transcriptional Regulatory ◽  
Transcriptional Regulatory Mechanisms

scholarly journals The Role of Non-Coding RNA in Congenital Heart Diseases

2019 ◽  
Vol 6 (2) ◽  
pp. 15 ◽  
Author(s):  
Angel Dueñas ◽  
Almudena Expósito ◽  
Amelia Aranega ◽  
Diego Franco
Keyword(s):  
Congenital Heart ◽  
Heart Diseases ◽  
Regulatory Mechanisms ◽  
Congenital Heart Diseases ◽  
Cardiovascular Development ◽  
Transcriptional Regulatory ◽  
Non Coding Rnas ◽  
Transcriptional Regulatory Mechanisms ◽  
The Impact

Cardiovascular development is a complex developmental process starting with the formation of an early straight heart tube, followed by a rightward looping and the configuration of atrial and ventricular chambers. The subsequent step allows the separation of these cardiac chambers leading to the formation of a four-chambered organ. Impairment in any of these developmental processes invariably leads to cardiac defects. Importantly, our understanding of the developmental defects causing cardiac congenital heart diseases has largely increased over the last decades. The advent of the molecular era allowed to bridge morphogenetic with genetic defects and therefore our current understanding of the transcriptional regulation of cardiac morphogenesis has enormously increased. Moreover, the impact of environmental agents to genetic cascades has been demonstrated as well as of novel genomic mechanisms modulating gene regulation such as post-transcriptional regulatory mechanisms. Among post-transcriptional regulatory mechanisms, non-coding RNAs, including therein microRNAs and lncRNAs, are emerging to play pivotal roles. In this review, we summarize current knowledge on the functional role of non-coding RNAs in distinct congenital heart diseases, with particular emphasis on microRNAs and long non-coding RNAs.

scholarly journals Beyond Ethylene: New Insights Regarding the Role of AOX in the Respiratory Climacteric

2019 ◽  
Author(s):  
Seanna Hewitt ◽  
Amit Dhingra
Keyword(s):  
Ethylene Production ◽  
Respiratory Pathway ◽  
Physiological Models ◽  
Atp Production ◽  
Climacteric Fruit ◽  
Transcriptional Regulatory ◽  
System 2 ◽  
Transcriptional Regulatory Mechanisms ◽  
System 1

Climacteric fruits are characterized by a dramatic increase in autocatalytic ethylene production, which is accompanied by a spike in respiration, at the onset of ripening. The change in the mode of ethylene production from autoinhibitory to auto-stimulatory is known as the system 1 (S1) to system 2 (S2) transition. Existing physiological models explain the basic and overarching genetic, hormonal, and transcriptional regulatory mechanisms governing the S1 to S2 transition of climacteric fruit. However, the links between ethylene and respiration, the two main factors that characterize the respiratory climacteric, have been largely understudied at the molecular level. Results of recent studies indicate that the AOX respiratory pathway may play an important role in mediating cross talk between ethylene response, carbon metabolism, ATP production, and ROS signaling during climacteric ripening. New genomic, metabolic, and epigenetic information sheds light on the interconnectedness of ripening-associated metabolic pathways, necessitating expanding the current, ethylene-centric physiological models. Understanding points at which ripening responses can be manipulated may reveal key, speciesand cultivar-specific targets for regulation of ripening enabling superior strategies for reducing postharvest wastage.

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