scholarly journals DNA Binding Potency and Antimicrobial Analysis of New Indole and Pyrazolone Based Transition Metal(II) Complexes

2020 ◽  
Vol 32 (8) ◽  
pp. 1903-1908
Author(s):  
Murugan Selvamariammal ◽  
Maruthappan Malarvizhi
Keyword(s):  
Dna Binding ◽  
Transition Metal ◽  
Metal Complexes ◽  
Spectral Data ◽  
Schiff Bases ◽  
Electronic Absorption ◽  
Free Ligand ◽  
Spectral Techniques ◽  
Intercalative Mode ◽  
Calf Thymus

Some novel series of 5-chloro isatin and 4-aminoantipyrine based Schiff bases with transition metal(II) complexes of (Cu, Co, Ni and Zn) have been prepared and characterized by physical, analytical and spectral data. The synthesized ligand behaves as a neutral tridentate is confirmed by spectral techniques. During the complexation, the stoichiometry ratio 1:2 (metal:ligand) is followed and an octahedral arrangement is adopted by all the metal complexes. The calf-thymus DNA interacts with complexes via an intercalative mode is studied by electronic absorption titration. Moreover, all these synthesized metal(II) complexes were tested against a set of bacterial and fungal strains reveals that complexes exhibit better activity than free ligand.

Synthesis, Characterization and in vitro Biological Evaluation of a New Schiff Base Derived from Drug and its Complexes with Transition Metal Ions

2018 ◽  
Vol 69 (7) ◽  
pp. 1678-1681
Author(s):  
Amina Mumtaz ◽  
Tariq Mahmud ◽  
M. R. J. Elsegood ◽  
G. W. Weaver
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Ions ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Free Ligand ◽  
Transition Metal Ions ◽  
Biological Evaluation ◽  
Pyridoxal Hydrochloride

New series of copper (II), cobalt (II), zinc (II), nickel (II), manganese (II), iron (II) complexes of a novel Schiff base were prepared by the condensation of sulphadizine and pyridoxal hydrochloride. The ligand and metal complexes were characterized by utilizing different instrumental procedures like microanalysis, thermogravimetric examination and spectroscopy. The integrated ligand and transition metal complexes were screened against various bacteria and fungus. The studies demonstrated the enhanced activity of metal complexes against reported microbes when compared with free ligand.

DNA Binding Mode of Transition Metal Complexes, A Relationship to Tumor Cell Toxicity

2014 ◽  
Vol 21 (26) ◽  
pp. 3081-3094 ◽  
Author(s):  
M. Ashfaq ◽  
T. Najam ◽  
S.S.A. Shah ◽  
M.M. Ahmad ◽  
S. Shaheen ◽  
...  
Keyword(s):  
Dna Binding ◽  
Transition Metal ◽  
Tumor Cell ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Binding Mode ◽  
Cell Toxicity

scholarly journals Metal Complexes of Schiff Bases of 3-Hydroxyquinoxaline-2-carboxaldehyde Encapsulated in Zeolite Y Cages: Potential Catalyst for Removing Phenol from Effluent Media

2021 ◽  
Vol 33 (11) ◽  
pp. 2746-2754
Author(s):  
N.R. Suja ◽  
T.K. Bindu Sharmila ◽  
S.R. Amrutha
Keyword(s):  
Catalytic Activity ◽  
Transition Metal ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Transition Metal Complexes ◽  
Zeolite Y ◽  
Point Of View ◽  
Organic Transformations ◽  
Efficient Catalyst ◽  
Industrial Pollutants

Transition metal complexes are known to be efficient catalyst for many organic transformations. Encapsulation of metal complexes in zeolite cage brings many significant modifications in the structure of the metal complexes, which are very interesting from the catalytic point of view. This study aims in a comparative evaluation of the influence of structure of neat and encapsulated complexes in their catalytic activity. Phenol is one of the major industrial pollutants. Heterogenizing transition metal Schiff bases by encapsulation inside the zeolite would help to minimize the reuse problem of transition metal complexes. This article deals with the synthesis, characterization and catalytic activity studies of Co(II), Ni(II) and Cu(II) complexes of 3-hydroxyquinoxaline-2-carboxaldehyde with ethylenediamine (L1) and an o-phenylene diamine (L2).

Antimicrobial and Toxicological Studies of Mixed Ligand Transition Metal Complexes of Schiff Bases

2002 ◽  
Vol 2 (12) ◽  
pp. 797-799 ◽  
Author(s):  
M. Saidul Islam . ◽  
M. Akhter Farooque . ◽  
M.A.K. Bodruddoza . ◽  
M. Ashik Mosaddik . ◽  
M. Shahidul Alam .
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Transition Metal Complexes ◽  
Mixed Ligand ◽  
Toxicological Studies
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