Determination of Satranidazole through Ion-Associative Complex Reaction

A simple, selective, accurate and low-cost spectrophotometric method has been described for determination of satranidazole in bulk and pharmaceutical formulations. The developed method involves the formation of chloroform extractable colored ion-association complex of satranidazole with Tropaeolin OOO (TPooo). The extracted colored complex showed absorbance maximum at wavelength 484 nm and obeying Beer′s law in the concentration 4-20 μg mL-1 with the correlation coeffiecent of 0.9998. The results of statistical analysis of the proposed method reveals high accuracy and good precession. Thus, the proposed method can be used commercially for the determination of satranidazole in bulk and pharmaceutical formulations.

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Ion Association Methods for the Determination of Fexofenadine in Pharmaceutical Preparations

E-Journal of Chemistry ◽

10.1155/2005/370478 ◽

2005 ◽

Vol 2 (3) ◽

pp. 199-202 ◽

Cited By ~ 2

Author(s):

L. D. Srinivas ◽

P. Ravi Kumar ◽

B. S. Sastry

Keyword(s):

Pharmaceutical Preparations ◽

Ion Association ◽

Pharmaceutical Formulations ◽

Bulk Sample ◽

Acid Group ◽

Carboxylic Acid Group ◽

Spectrophotometric Methods ◽

Safranin O ◽

Association Complex

Two simple and sensitive Visible spectrophotometric methods (A and B) for the determination of Fexofenadine (FEX) in bulk sample and pharmaceutical formulations are described. Methods A and B are based on the formation of ion-association complex involving carboxylic acid group of FEX and the basic dyes, Safranin-O (SFN-O, method A), methylene blue (MB, method B). The results obtained in the above two methods are reproducible and are statistically validated and found to be suitable for the assay of Fexofenadine in bulk and its pharmaceutical formulations.

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USE OF ION ASSOCIATION COMPLEX FORMATION FOR THE SPECTROPHOTOMETRIC DETERMINATION OF ITOPRIDE HCL IN BULK AND ITS PHARMACEUTICAL PREPARATIONS

International Journal of Current Pharmaceutical Research ◽

10.22159/ijcpr.2017v9i1.16620 ◽

2016 ◽

Vol 9 (1) ◽

pp. 81

Author(s):

P. V. Lakshmana Rao ◽

C. Rambabu

Keyword(s):

Complex Formation ◽

Spectrophotometric Determination ◽

Pharmaceutical Preparations ◽

Ion Association ◽

Pharmaceutical Formulations ◽

Spectrophotometric Methods ◽

Itopride Hydrochloride ◽

Soluble Ion ◽

Association Complex

Objective: The authors report two simple, accurate and economic spectrophotometric methods A and B for the determination of Itopride hydrochloride in bulk and dosage forms.Methods: The proposed methods are based on the formation of chloroform soluble ion-associates in the presence of acidic dyes namely BPB (Method A) and BCP (Method B) exhibiting lmax at 418 and 418 nm respectively.Results: Beer’s law is found to be obeyed in the concentration range of 2.0-10.0 µg/ml and 2.0-10.0 µg/ml. The molar absorptivities are found to be 1.42x104 and 9.61x103L/mol. cm for methods A and B. These methods are successfully applied for the assay of Itopride hydrochloride in pharmaceutical formulations.

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Spectrophotometric Determination of Ceftibuten in Bulk and in Pharmaceutical Formulations

E-Journal of Chemistry ◽

10.1155/2010/120417 ◽

2010 ◽

Vol 7 (2) ◽

pp. 551-554 ◽

Cited By ~ 2

Author(s):

R. Vijayalakshmi ◽

P. Bhargavi ◽

P. Srujana Kumari ◽

P. Sruthi ◽

M. D. Dhanaraju

Keyword(s):

Statistical Analysis ◽

Absorption Maximum ◽

Regression Line ◽

Cost Effective ◽

Pharmaceutical Formulations ◽

High Accuracy ◽

Molar Absorptivity ◽

Good Precision ◽

Experimental Parameters

A simple and cost effective spectrophotometric method is described for the determination of ceftibuten in pure form and in pharmaceutical formulations. The method is based on the formation of blue colored chromogen, when the drug reacts with Folin-Ciocalteu (F-C) reagent in alkaline medium. The colored species has an absorption maximum at 798 nm and obeys Beer’s law in the concentration range 10-50 mcg/mL. The apparent molar absorptivity and sandell’s sensitivity were 0.4583x104and 0.3x104respectively. The slope and intercept of the equation of the regression line are 4.5x10-3and 1.3x10-5respectively. The optimum experimental parameters for the reaction have been studied and the validity of the described procedure was assessed. Statistical analysis of the results has been carried out revealing high accuracy and good precision. The proposed method was successfully applied for the determination of ceftibuten in pharmaceutical formulations.

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New Extractive Spectrophotometric Method Development and Validation for the Estimation of Danazol in Pharmaceutical Formulations

Asian Journal of Organic & Medicinal Chemistry ◽

10.14233/ajomc.2019.ajomc-p169 ◽

2019 ◽

Vol 4 (1) ◽

pp. 36-39

Author(s):

K. Rama Devi ◽

K. Kiran Kumar ◽

G. Krishnaveni

Keyword(s):

Statistical Analysis ◽

Spectrophotometric Method ◽

Method Development ◽

Ion Association ◽

Pharmaceutical Formulations ◽

High Accuracy ◽

Good Precision ◽

Method Development And Validation ◽

Bulk Drug ◽

Development And Validation

A simple, sensitive, selective, accurate and economical spectrophoto-metric method have been described in the present work for the deter-mination of danazol in bulk drug and pharmaceutical formulations (tablets). Method is based on the formation of yellow coloured ion-association complexes between danazol and alizarine red S in acid medium followed by their extraction with chloroform, exhibiting absorption maxima at 430 nm, and obeying Beer′s law in the concen-tration range of 5-30 μg/mL. Statistical analysis of the results of the proposed methods reveals high accuracy and good precision. The proposed methods could be successfully extended to the commercial pharmaceutical formulations containing danazol.

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Spectrophotometric Determination of Atenolol by Formation of Ion Association Complex

International Journal of Pharmaceutical Research ◽

10.31838/ijpr/2020.sp1.202 ◽

2020 ◽

Vol 12 (sp1) ◽

Keyword(s):

Spectrophotometric Determination ◽

Ion Association ◽

Association Complex

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Applicability of Cork as Novel Modifiers to Develop Electrochemical Sensor for Caffeine Determination

Materials ◽

10.3390/ma14010037 ◽

2020 ◽

Vol 14 (1) ◽

pp. 37

Author(s):

Mayra K. S. Monteiro ◽

Djalma R. Da Silva ◽

Marco A. Quiroz ◽

Vítor J. P. Vilar ◽

Carlos A. Martínez-Huitle ◽

...

Keyword(s):

Electrochemical Sensor ◽

Linear Response ◽

High Performance ◽

Low Cost ◽

Pharmaceutical Formulations ◽

Caffeine Concentration ◽

Real Samples ◽

Wide Range ◽

Potential Use

This study aims to investigate the applicability of a hybrid electrochemical sensor composed of cork and graphite (Gr) for detecting caffeine in aqueous solutions. Raw cork (RAC) and regranulated cork (RGC, obtained by thermal treatment of RAC with steam at 380 °C) were tested as modifiers. The results clearly showed that the cork-graphite sensors, GrRAC and GrRGC, exhibited a linear response over a wide range of caffeine concentration (5–1000 µM), with R2 of 0.99 and 0.98, respectively. The limits of detection (LOD), estimated at 2.9 and 6.1 µM for GrRAC and GrRGC, suggest greater sensitivity and reproducibility than the unmodified conventional graphite sensor. The low-cost cork-graphite sensors were successfully applied in the determination of caffeine in soft drinks and pharmaceutical formulations, presenting well-defined current signals when analyzing real samples. When comparing electrochemical determinations and high performance liquid chromatography measurements, no significant differences were observed (mean accuracy 3.0%), highlighting the potential use of these sensors to determine caffeine in different samples.

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VISIBLE SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION OF IMATINIB IN BULK AND FORMULATION

International Journal of Current Pharmaceutical Research ◽

10.22159/ijcpr.2020v12i2.37491 ◽

2020 ◽

pp. 63-67

Author(s):

SMITA KUMBHAR ◽

VINOD MATOLE ◽

YOGESH THORAT ◽

ANITA SHEGAONKAR ◽

AVINASH HOSMANI

Keyword(s):

Spectrophotometric Method ◽

Method Development ◽

Pharmaceutical Formulations ◽

Uv Spectrum ◽

Colored Complex ◽

Pharmaceutical Dosage Forms ◽

Highly Sensitive ◽

Method Development And Validation ◽

Development And Validation

Objective: A new, simple, sensitive, precise and reproducible UV visible spectrophotometric method was developed for the determination of Imatinib in pharmaceutical formulations with alizarin. Methods: The method is based on formation of yellow-colored complex. The UV spectrum of Imatinib in methanol showed λ max at 431 nm. Beer’s law is valid in the concentration range of 10-70 μg/ml. This method was validated for linearity, accuracy, precision, ruggedness and robustness. Results: The method has demonstrated excellent linearity over the range of 10-70 μg/ml with regression equation y =0.013x-0.017 and regression correlation coefficient r2= 0.997. Moreover, the method was found to be highly sensitive with LOD (4.3μg/ml) and LOQ (13.07μg/ml). Conclusion: Based on results the proposed method can be successfully applied for the assay of Imatinib in various pharmaceutical dosage forms.

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