DARNING HERNIOPLASTY VS. MESH HERNIOPLASTY- A NON-RANDOMISED CONTROLLED TRIAL WITH 3 YEARS FOLLOWUP IN A TERTIARY CARE HOSPITAL, RAJAHMUNDRY, ANDHRA PRADESH, INDIA

Background: Pre-eclampsia (PE) is a disorder of pregnancy characterized by the onset of high blood pressure and often a significant amount of protein in the urine. Pre-eclampsia is one of the leading causes of maternal and perinatal morbidity and mortality worldwide. The objective of the present study was to assess and compare the safety and efficacy of oral nifedipine and intravenous labetalol in the management of severe pre-eclampsia.Methods: A double-blind, randomized, controlled trial was conducted at a tertiary care hospital in Andhra Pradesh, on pregnant women presenting with a systolic blood pressure of 160 mm Hg or more or diastolic blood pressure of 110 mm Hg or more. The pregnant women were randomized to receive Oral nifedipine (10 mg tablet orally up to five doses) and intravenous labetalol injection in escalating doses until the target blood pressure of 150 mm Hg systolic and 100 mm Hg diastolic, or lower, was achieved. The primary endpoint of the study was the time taken by each agent to achieve target blood pressure. Secondary endpoints were number of doses required, adverse maternal and neonatal effects, side effect profile, and perinatal outcome.Results: The study was conducted in a tertiary care hospital in Andhra Pradesh from July 2016 to October 2017, on 100 pregnant women presenting with preeclampsia. The median time taken to achieve target blood pressure was 44 minutes (range: 20-60 minutes) for Oral Nifedipine and 68 minutes (range: 40-85 minutes) for Intravenous labetalol (P=0.008). No serious adverse maternal or perinatal side effects were encountered in both the groups.Conclusions: Both oral nifedipine and intravenous labetalol are effective in the management of acute hypertensive emergencies of pregnancy; however, oral nifedipine effectively decreased the blood pressure rapidly compared to intravenous labetalol.

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Investigating the impact of patient-centred labels on comprehension of medication dosing: a randomised controlled trial

BMJ Open ◽

10.1136/bmjopen-2021-053969 ◽

2021 ◽

Vol 11 (11) ◽

pp. e053969

Author(s):

Ahsan Saleem ◽

Gemma Woodruff ◽

Kathryn Steadman ◽

Adam La Caze

Keyword(s):

Health Literacy ◽

Randomised Controlled Trial ◽

Controlled Trial ◽

Tertiary Care ◽

Vital Signs ◽

Pharmacy Practice ◽

Care Hospital ◽

Randomised Controlled ◽

The Impact ◽

High Health Literacy

ObjectiveThis study aims to implement a version of patient-centred labels (PCL) consistent with current labelling practice in Australia; assess the effectiveness of PCL in relation to the proportion of participants that correctly comprehend dosing instructions, and explore the proportion of correct comprehension of PCL in participants with both low and high health literacy.DesignRandomised controlled trial.SettingA large tertiary care hospital in Brisbane, Queensland, Australia.Participants121 participants with a majority born in Australia (65.3%), New Zealand (14.0%), the UK (6.6%) and Ireland (2.5%).InterventionParticipants were randomly assigned to either a panel of three PCL (n=61) or three standard labels (n=60) and asked to comprehend their assigned panel of labels.Outcome measuresDifference in the proportion of participants that correctly comprehend dosing instructions provided on PCL compared with standard labels. The two-proportion test was used to measure the impact of PCL on the proportion of participants correctly comprehending dosing instructions.ResultsA greater proportion of participants were able to accurately comprehend PCL compared with standard labels. The proportion of participants who were able to correctly comprehend dose instructions provided on all three labels was significantly higher in the group that received PCL; 23.3% standard vs 83.6% PCL, p<0.001. The effect was observed in both low and high health literacy participants. The proportion of participants with accurate label comprehension was higher in participants with low Newest Vital Signs scores (8.3% standard vs 85.7% PCL, p<0.001) and low Rapid Estimate of Adult Literacy in Medicine scores (10.5% standard vs 96.0% PCL, p<0.001) who received PCL.ConclusionThis study supports the use of PCL in Australian pharmacy practice. PCL provide simple, clear and explicit dosing instructions to patients. Implementing PCL may reduce the risk of misinterpreting dosing instructions by patients and improve quality use of medicines.Trial registration numberACTRN12621000083897; Results.

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A randomized controlled trial on management of distal radius fractures with plating followed by pronator quadratus repair versus no repair in a tertiary care hospital in Andhra Pradesh, India

MedPulse International Journal of Orthopedics ◽

10.26611/10201012 ◽

2019 ◽

Vol 10 (1) ◽

pp. 07-12

Author(s):

Rajasekhar Rao G ◽

◽

Nageswara Rao V ◽

, Lavanya K M ◽

Sujith Kumar V ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Distal Radius ◽

Andhra Pradesh ◽

Tertiary Care Hospital ◽

Controlled Trial ◽

Tertiary Care ◽

Care Hospital ◽

Radius Fractures ◽

Pronator Quadratus ◽

Randomized Controlled

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Camp-based family treatment of childhood obesity: randomised controlled trial

Archives of Disease in Childhood ◽

10.1136/archdischild-2015-309813 ◽

2016 ◽

Vol 102 (4) ◽

pp. 303-310 ◽

Cited By ~ 6

Author(s):

Beate Benestad ◽

Samira Lekhal ◽

Milada Cvancarova Småstuen ◽

Jens Kristoffer Hertel ◽

Vidar Halsteinli ◽

...

Keyword(s):

Randomised Controlled Trial ◽

Summer Camp ◽

Controlled Trial ◽

Tertiary Care ◽

Family Treatment ◽

Care Hospital ◽

Treatment Programme ◽

Registration Number ◽

Family Based ◽

Randomised Controlled

ObjectiveTo compare the effectiveness of a 2-year camp-based family treatment programme and an outpatient programme on obesity in two generations.DesignPragmatic randomised controlled trial.SettingRehabilitation clinic, tertiary care hospital and primary care.PatientsFamilies with at least one child (7–12 years) and one parent with obesity.InterventionsSummer camp for 2 weeks and 4 repetition weekends or lifestyle school including 4 days family education. Behavioural techniques motivating participants to healthier lifestyle.Main outcome measuresChildren: 2-year changes in body mass index (BMI) SD score (SDS). Parents: 2-year change in BMI. Main analyses: linear mixed models.ResultsNinety children (50% girls) were included. Baseline mean (SD) age was 9.7 (1.2) years, BMI 28.7 (3.9) kg/m2 and BMI SDS 3.46 (0.75). The summer-camp children had a lower adjusted estimated mean (95% CI) increase in BMI (−0.8 (−3.5 to −0.2) kg/m2), but the BMI SDS reductions did not differ significantly (−0.11 (−0.49 to 0.05)). The 2-year baseline adjusted BMI and BMI SDS did not differ significantly between summer-camp and lifestyle-school completers, BMI 29.8 (29.1 to 30.6) vs 30.7 (29.8 to 31.6) kg/m2 and BMI SDS 2.96 (2.85 to 3.08) vs 3.11 (2.97 to 3.24), respectively. The summer-camp parents had a small reduction in BMI (−0.9 (−1.8 to −0.03) vs −0.8 (−2.1 to 0.4) in the lifestyle-school group), but the within-group changes did not differ significantly (0.3 (−1.7 to 2.2)).ConclusionsA 2-year family camp-based obesity treatment programme had no significant effect on BMI SDS in children with severe obesity compared with an outpatient family-based treatment programme.Trial registration numberNCT01110096.

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