Results of Distal Tibia Extra-Articular Type I & Type II Open Fractures Treated with Primary Ilizarov External Fixator - A Prospective Observational Study

Abstract The objective of this study is to compare the radiographic results and clinical outcome of unreamed tibial nailing (UTN) and Ilizarov external fixation (IEF) for the treatment of open fractures of the tibia. Patients with open tibial shaft fractures were treated with an IEF or UTN. Both groups were compared for union time, nonunion, infections, mechanical failure of the implant, and malunion. We searched numerous sources and eventually included studies, totaling participants.

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Prospective observational study for the impact of short-term periodic intravenous steroid premedication for gastrointestinal cancer chemotherapy on bone metabolism.

Journal of Clinical Oncology ◽

10.1200/jco.2016.34.4_suppl.523 ◽

2016 ◽

Vol 34 (4_suppl) ◽

pp. 523-523

Author(s):

Atsushi Ishiguro ◽

Michio Nakamura ◽

Tetsuhito Muranaka ◽

Satoshi Yuki ◽

Taichi Murai ◽

...

Keyword(s):

Observational Study ◽

Bone Turnover ◽

Bone Metabolism ◽

Gastrointestinal Cancer ◽

Prospective Observational Study ◽

Type I Collagen ◽

Reduction Rate ◽

Type I ◽

Significant Difference ◽

The Impact

523 Background: Although intravenous glucocorticoid (GC) premedication (GCP) before chemotherapy (CTx) are frequently used to prevent nausea and vomiting for continuing comfortable CTx, the side effects of intermittent GCs on bone health have not yet been reported. So we designed a multicenter, prospective, observational study to evaluate the impact of periodic GCP on bone metabolism in gastrointestinal cancer (GIC) patients (pts). Methods: The eligibility criteria were as the follows: (i) histologically proven GIC. ; (ii) The duration of periodical GCP is weekly, biweekly, and triweekly. More over 4 weeks GC free intervals is not permissible. ; (iii) age over 20. The primary endpoint was to investigate the variations of bone mineral densities (BMD) at lumbar spine measured by dual energy x-ray absorptiometry (DEXA) and bone turnover biomarkers, cross-linked N-telopeptide of type I collagen (NTX) and bone alkaline phosphatase (BAP), between baseline (BL) and 16 weeks after starting CTx (16w). Results: From June 2013 to April 2015, 98 pts were enrolled. Two pts were not proven as GIC histologically. One patient (pt) was not measured on baseline DEXA. One pt was taken bisphosphonates already on BL point. Four pts were not administered CTx or GCP, and 16 pts were not measured BMD on 16w due to several reasons such as pts refusal, discontinuation of CTx, death and so on (74 pts were full analysis set). In 55 pts (74.3 % of FAS), the levels of BMD at 16w were decreased compared with BL and the average amount of BMD reduction rate was 5.83 % (-38.8 % to 31.1 %). Although no significant difference was found in the level of NTX between BL and 16w (p = 0.118), there was the significant increase of BAP level statistically (p = 0.006). There were also significant correlations between percent change in BMD and NTX, BMD and BAP, NTX and BAP (p = 0.037, 0.029, and 0.003, respectively). Conclusions: We found that periodic GCP in GIC pts caused the reduction of BMD and some influences for bone turnover. These results indicate that GCP might generate more serious osteoporosis of GIC pts during CTx. Further studies are necessary to illustrate the need to prevent GC induced osteoporosis in using GCP. Clinical trial information: 000011054.

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Treatment of Periarticular Open Fractures of the Tibia with Ilizarov External Fixator

The Journal of the Korean Orthopaedic Association ◽

10.4055/jkoa.1992.27.7.1745 ◽

1992 ◽

Vol 27 (7) ◽

pp. 1745

Author(s):

Kyung Chul Kim ◽

Sung Joon Im ◽

Bo Seok Kong ◽

Bo Hyeong Bang

Keyword(s):

External Fixator ◽

Open Fractures ◽

Ilizarov External Fixator

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Evaluation of in vitro chemoresponse profiles in women with Type I and Type II epithelial ovarian cancers: An observational study ancillary analysis

Gynecologic Oncology ◽

10.1016/j.ygyno.2015.05.038 ◽

2015 ◽

Vol 138 (2) ◽

pp. 267-271 ◽

Cited By ~ 4

Author(s):

Rebecca Previs ◽

Charles A. Leath ◽

Robert L. Coleman ◽

Thomas J. Herzog ◽

Thomas C. Krivak ◽

...

Keyword(s):

Observational Study ◽

Type I ◽

Type Ii ◽

Ovarian Cancers

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An observational study into the management of arteriomegaly: a call for a revised classification system

Annals of The Royal College of Surgeons of England ◽

10.1308/003588412x13171221498505 ◽

2012 ◽

Vol 94 (4) ◽

pp. 250-255 ◽

Cited By ~ 2

Author(s):

JV Barandiaran ◽

TC Hall ◽

I Glaves ◽

N El-Barghouti ◽

EP Perry

Keyword(s):

Observational Study ◽

Critical Limb Ischaemia ◽

Limb Ischaemia ◽

Type I ◽

Type Ii ◽

Type Iii ◽

Cerebrovascular Events ◽

Progression Of Disease ◽

Artery Disease

INTRODUCTION Arteriomegaly is the diffuse ectasia of arteries with or without aneurysmal disease. Patients with arteriomegaly have a higher incidence of morbidity including limb loss compared to patients with other arteriopathies. The aim of this observational study was to review the management of these patients in our institution. METHODS Radiologists and surgeons prospectively reviewed aortofemoral angiography. Patients with arteriomegaly were identified. Data relating to demographics, mode of presentation, risk factors, type of arteriomegaly, management and progression of disease were analysed. RESULTS Arteriomegaly was identified in 1.3% of patients (n=69) undergoing lower limb angiography in the study period. Of these, the majority (n=67) were men. The mean age was 74 years (range: 60–89 years) and 76% were smokers. Co-morbidities included coronary artery disease (55%), diabetes mellitus (20%), hypertension (45%) and cerebrovascular events (6%). Fortynine patients presented with critical limb ischaemia and eighteen patients were seen electively in the outpatients department with symptoms of intermittent claudication. Data were incomplete for two male patients and were therefore not included. At presentation, 22 patients were classified as Hoi lier type I, 5 were type II and 9 were type III. Thirty-one patients had arteriomegalic vessels but no aneurysmal disease. After a median follow-up duration of 76 months (range: 6–146 months), 34 patients progressed to type I, 2 to type II and 18 to type III. Thirteen remained without aneurysmal disease. Twenty-nine patients required angioplasty and twenty-eight required bypass surgery during this time. In total, 102 procedures were required for complicated disease. The limb salvage rate was 92%. Although 8 patients in our series died, the remaining 59 are under regular follow up. CONCLUSIONS This study illustrates the progressive nature of arteriomegaly. Results of the management of these patients in our institution are similar to those in the literature. We suggest an additional fourth category to Hollier’s classification that describes arteriomegalic disease without aneurysmal degeneration as this, too, deserves special management. Regular follow-up visits and early intervention for patients with arteriomegaly is advocated to reduce the high incidence of morbidity.

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