SPECIES DISTRIBUTION AND ANTIFUNGAL SUSCEPTIBILITY PROFILE OF CANDIDA SPECIES ISOLATED FROM BLOOD STREAM INFECTIONS

Candidaspp. have emerged as successful pathogens in both invasive and mucosal infections. Varied virulence factors and growing resistance to antifungal agents have contributed to their pathogenicity. We studied diagnostic accuracy of HiCromeCandidaDifferential Agar and Vitek 2 Compact system for identification ofCandidaspp. in comparison with species-specific PCR on 110 clinical isolates ofCandidafrom blood stream infections (54, 49%) and vulvovaginal candidiasis (56, 51%).C. albicans(61%) was the leading pathogen in VVC, whileC. tropicalis(46%) was prominent among BSIs. HiCrome Agar and Vitek 2 Compact had good measures of agreement (κ) 0.826 and 0.895, respectively, in comparison with PCR. We also tested these isolates forin vitroproduction of proteinase, esterase, phospholipases, and biofilms. Proteinase production was more among invasive isolates (P=0.017), while phospholipase production was more among noninvasive isolates (P=0.001). There was an overall increase in the production of virulence factors among non-albicansCandida. Identification of clinical isolates ofCandidaup to species level either by chromogenic agar or by Vitek 2 Compact system should be routinely done to choose appropriate therapy.

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Species distribution of Candida species isolated from sterile body fluids and its antifungal susceptibility pattern in UMMC

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2020.09.1023 ◽

2020 ◽

Vol 101 ◽

pp. 390-391

Author(s):

J. Abd Aziz ◽

N. Atiya ◽

R.D. Velayuthan

Keyword(s):

Species Distribution ◽

Candida Species ◽

Antifungal Susceptibility ◽

Body Fluids ◽

Susceptibility Pattern ◽

Sterile Body Fluids

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Species distribution of yeasts recovered from different clinical samples Addiss Ababa,Ethiopia

10.21203/rs.2.9212/v2 ◽

2019 ◽

Author(s):

Elias Seyoum Deribe ◽

Adane Bitew ◽

Amete Mihret

Keyword(s):

Species Distribution ◽

Candida Species ◽

Fungal Infections ◽

Addis Ababa ◽

Antifungal Susceptibility ◽

Signs And Symptoms ◽

Cross Sectional Study ◽

Clinical Samples ◽

Cross Sectional ◽

Reported Data

Abstract Background Currently, fungal diseases of humans are among the most problematic illnesses is the result of an increase in opportunistic fungal infections caused by rise in the number of immune-compromised patients. Particularly, yeasts are the most common cause of fungal infections leading to a range superficial type to life-threatening invasive infections. The aim of this study is to determine species distribution of yeasts particularly of Candida species recovered from different clinical samples. Method A cross sectional study was conducted from January 01, 2018 –September 30, 2018 in Addis Ababa, Arsho laboratory. Oropharengial swabs, nail scrapings, sputum, corneal scrapings, and vaginal swabs were collected from patients with signs and symptoms of infections. Identification and antifungal susceptibility testing was performed by using YST card through VITEK 2 compact system. Data was entered and analyzed using SPSS version 20. Result A total of 209 yeasts were recovered of which 49.8% were Candida albicans, 43.1% were non-albicans candida species and 7.2% were yeasts other than Candida species. The current study, eighteen (18) different types of yeast species were identified from different clinical samples. All recognized yeast considered as a causative agent of fungal infection in previously reported data in worldwide. Conclusion C. albicans remaining the predominant species, but the emergence of non-albicans Candida and other than candida species have increased. Thus, more studies on Candida prevalence are needed throughout country.

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Species distribution of yeasts recovered from different clinical samples Addiss Ababa,Ethiopia

10.21203/rs.2.9212/v1 ◽

2019 ◽

Author(s):

Elias Seyoum Deribe ◽

Adane Bitew ◽

Amete Mihret

Keyword(s):

Species Distribution ◽

Candida Species ◽

Fungal Infections ◽

Addis Ababa ◽

Antifungal Susceptibility ◽

Signs And Symptoms ◽

Cross Sectional Study ◽

Clinical Samples ◽

Cross Sectional ◽

Reported Data

Abstract Background Currently, fungal diseases of humans are among the most problematic illnesses is the result of an increase in opportunistic fungal infections caused by rise in the number of immune-compromised patients. Particularly, yeasts are the most common cause of fungal infections leading to a range superficial type to life-threatening invasive infections. The aim of this study is to determine species distribution of yeasts particularly of Candida species recovered from different clinical samples. Method A cross sectional study was conducted from January 01, 2018 –September 30, 2018 in Addis Ababa, Arsho laboratory. Oropharengial swabs, nail scrapings, sputum, corneal scrapings, and vaginal swabs were collected from patients with signs and symptoms of infections. Identification and antifungal susceptibility testing was performed by using YST card through VITEK 2 compact system. Data was entered and analyzed using SPSS version 20. Result A total of 209 yeasts were recovered of which 49.8% were Candida albicans, 43.1% were non-albicans candida species and 7.2% were yeasts other than Candida species. The current study, eighteen (18) different types of yeast species were identified from different clinical samples. All recognized yeast considered as a causative agent of fungal infection in previously reported data in worldwide. Conclusion C. albicans remaining the predominant species, but the emergence of non-albicans Candida and other than candida species have increased. Thus, more studies on Candida prevalence are needed throughout country.

Download Full-text