scholarly journals Single Nucleotide Polymorphisms Associated With Alimentary Fatty Liver Disease Are Not Genetic Risk Factors For Treatment-associated Hepatic Steatosis In HIV Patients On HAART.

2013 ◽  
Vol 1 (2) ◽  
pp. 1-4 ◽  
Author(s):  
Leona Dold ◽  
Cordula Berger ◽  
Carolin Luda ◽  
Christoph Boesecke ◽  
Carolynne Schwarze-Zander ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Disease ◽  
Single Nucleotide Polymorphisms ◽  
Fatty Liver ◽  
Hepatic Steatosis ◽  
Genetic Risk ◽  
Fatty Liver Disease ◽  
Nucleotide Polymorphisms ◽  
Hiv Patients ◽  
Single Nucleotide

Non-alcoholic fatty liver disease

2018 ◽  
Author(s):  
Emer Fitzpatrick
Keyword(s):  
Risk Factors ◽  
Liver Disease ◽  
Fatty Liver ◽  
Hepatic Steatosis ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

The chapter on non-alcoholic fatty liver disease includes the risk factors for this ever-increasing condition, the pathophysiology, as well as the differential of hepatic steatosis. Finally it includes the most current principles of its management.

scholarly journals Association of Glutathione S-transferases (GSTT1, GSTM1 and GSTP1) Genes Polymorphisms with Nonalcoholic Fatty Liver Disease Susceptibility: A Meta-analysis of Case-control Studies

2021 ◽  
Author(s):  
Yi Zhu ◽  
Ming Qiao
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Case Control ◽  
Nucleotide Polymorphisms ◽  
Case Control Studies ◽  
Single Nucleotide ◽  
Nonalcoholic Fatty Liver ◽  
Glutathione S Transferases

Abstract Background: Glutathione S-transferases (GSTs) genes single-nucleotide polymorphisms (SNPs) have been connected with the susceptibility of nonalcoholic fatty liver disease (NAFLD), but with inconsistent results across the current evidences. The present work was schemed to explore the association between GSTs genes polymorphisms and the NAFLD vulnerability via meta-analysis.Methods: PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI) and Wanfang were retrieved for eligible literatures previous to March 10, 2021. The odds ratio (OR) of the dichotomic variables and the standardized mean difference of quantitative variables with corresponding 95% confidence intervals (95%CIs) were computed to evaluate the strength of the associations. The quality of included studies were assessed via using Newcastle-Ottawa Scale (NOS).Results: In total, 7 case-control studies encompassing 804 NAFLD patients and 1362 disease-free controls in this meta-analysis. Ultimately, this analysis included six, five and five studies for GSTM1, GSTT1 and GSTP1 polymorphisms respectively. The pooled data revealed that the GSTs genes single-nucleotide polymorphisms had conspicuous associations with NAFLD susceptibility: for GSTM1, null vs. present, OR=1.46, 95%CI 1.20-1.79, P=0.0002; for GSTT1, null vs. present, OR=1.34, 95%CI 1.06-1.68, P=0.01; for GSTP1, Ile/Val or Val/Val vs. Ile/Ile, OR=1.60, 95%CI 1.23-2.09, P=0.0005.Conclusion: This work revealed that the GSTM1 null, GSTT1 null and GSTP1-Val genotypes might be related to increased NAFLD susceptibility.

scholarly journals Hepatic Steatosis and Diabetes Mellitus: Risk Factors, Pathophysiology and with its Clinical Implications: A Hospital Based Case Control Study in Western Region of Nepal

1970 ◽  
Vol 1 (2) ◽  
pp. 51-56
Author(s):  
Ankush Mittal ◽  
Brijesh Sathian ◽  
Nishida Chandrasekharan ◽  
Akshay Lekhi ◽  
Rashad Rahib ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Liver Disease ◽  
Fatty Liver ◽  
Hepatic Steatosis ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Mean Values ◽  
Diabetes Mellitus Risk ◽  
Control Study

Background: The perception of nonalcoholic fatty liver disease (NAFLD) as an infrequent and benign condition is swiftly altering in developing countries as there has been an upsurge in non alcoholic fatty liver disease in Asia-Pacific region. NAFLD develops across all age groups and societies and is recognized to occur in 14%–30% of the common population.  The foremost risk factors for NAFLD such as central obesity, diabetes mellitus, insulin resistance, dyslipidemia, hypertension, hypertriglyceridemia are currently predominant and puts a very large population at risk of evolving hepatic steatosis in the coming decades. Material and Methods: It was a hospital based case control study carried out in the Department of Biochemistry of Manipal Teaching Hospital, Pokhara, Nepal between 1st January 2010 and 31st Dec 2010. The variables collected were age, gender, fasting blood glucose, total cholesterol, low density lipoproteins, triglycerides, high density lipoproteins, very low density lipoproteins, aspartate transaminase, alanine transaminase. Results: Of the 200 patients of non alcoholic fatty liver disease patients   with diabetes mellitus, all  the variables except triglycerides shows insignificant disparity in relation to gender. The perceptible difference was observed in mean values of triglycerides for cases of NALFD between diabetes (218.25 ± SD 73.68) and non diabetic subjects (177.54 ± SD73.45) (p=.0001). The mean values of HDL did not illustrate much difference in cases of NALFD with diabetes (41.54 ± SD2.13) and non diabetic subjects (44.24 ± SD2.05). Conclusion: Public health initiatives are undoubtedly of the essence to halt or turn around the global 'diabesity' pandemic, the causal basis of NAFLD. Management of patients with NAFLD should be aimed at treating metabolic risk factors such as hyperglycemia and hypertriglyceridemia. Successful lifestyle adaptation with increased exercise and decreased food intake is able to remove the accumulation of liver fat and can reverse insulin resistance.Key words: Hepatic steatosis; Diabetes mellitus; Risk factors; Nepal.DOI: http://dx.doi.org/10.3126/nje.v1i2.5135 Nepal Journal of Epidemiology 2011;1 (2):51-56 

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