scholarly journals Association of Glutathione S-transferases (GSTT1, GSTM1 and GSTP1) Genes Polymorphisms with Nonalcoholic Fatty Liver Disease Susceptibility: A Meta-analysis of Case-control Studies

2021 ◽  
Author(s):  
Yi Zhu ◽  
Ming Qiao
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Case Control ◽  
Nucleotide Polymorphisms ◽  
Case Control Studies ◽  
Single Nucleotide ◽  
Nonalcoholic Fatty Liver ◽  
Glutathione S Transferases

Abstract Background: Glutathione S-transferases (GSTs) genes single-nucleotide polymorphisms (SNPs) have been connected with the susceptibility of nonalcoholic fatty liver disease (NAFLD), but with inconsistent results across the current evidences. The present work was schemed to explore the association between GSTs genes polymorphisms and the NAFLD vulnerability via meta-analysis.Methods: PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI) and Wanfang were retrieved for eligible literatures previous to March 10, 2021. The odds ratio (OR) of the dichotomic variables and the standardized mean difference of quantitative variables with corresponding 95% confidence intervals (95%CIs) were computed to evaluate the strength of the associations. The quality of included studies were assessed via using Newcastle-Ottawa Scale (NOS).Results: In total, 7 case-control studies encompassing 804 NAFLD patients and 1362 disease-free controls in this meta-analysis. Ultimately, this analysis included six, five and five studies for GSTM1, GSTT1 and GSTP1 polymorphisms respectively. The pooled data revealed that the GSTs genes single-nucleotide polymorphisms had conspicuous associations with NAFLD susceptibility: for GSTM1, null vs. present, OR=1.46, 95%CI 1.20-1.79, P=0.0002; for GSTT1, null vs. present, OR=1.34, 95%CI 1.06-1.68, P=0.01; for GSTP1, Ile/Val or Val/Val vs. Ile/Ile, OR=1.60, 95%CI 1.23-2.09, P=0.0005.Conclusion: This work revealed that the GSTM1 null, GSTT1 null and GSTP1-Val genotypes might be related to increased NAFLD susceptibility.

scholarly journals Association of PNPLA3 rs738409 G/C gene polymorphism with nonalcoholic fatty liver disease in children: a meta-analysis

2020 ◽  
Author(s):  
Shan Tang ◽  
Jing Zhang ◽  
Tingting Mei ◽  
Haiqing Guo ◽  
Xinhuan Wei ◽  
...  
Keyword(s):  
Liver Disease ◽  
Gene Polymorphism ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Alcoholic Fatty Liver ◽  
Nonalcoholic Fatty Liver ◽  
The Relationship

Objective:To systematically review the association of PNPLA3 rs738409 G/C gene polymorphism with non-alcoholic fatty liver disease(NAFLD) in children. Design: Systematic review and meta-analysis. Data sources and study selection: We searched MEDLINE, PubMed, EMBASE, and CENTRAL databases from inception to May 2019. Case-control studies assessing the relationship between PNPLA3 rs738409 G/C gene polymorphism with non-alcoholic fatty liver disease in children were selected according to inclusion and exclusion criteria. Data extraction and analyses: First author's surname, publication year, country, total numbers of patients in the case and control groups, sex ratio, and body mass index (BMI), as well as the numbers of cases and controls with the C/C, C/G and G/G genotypes were extracted from the included studies. Random effects model was used to quantify the association between the PNPLA3 rs738409 G/C gene polymorphism and the susceptibility of children's NAFLD. Fixed effects model was used to quantify the relationship between the PNPLA3 rs738409 G/C gene polymorphism and the severity of NAFLD in children. Results: A total of nine case-control studies were included in this meta-analysis containing data of 1173 children with NAFLD and 1792 healthy controls. Five studies compared NAFLD children and non-NAFLD healthy populations. Statistical analysis showed that PNPLA3 gene polymorphism was significantly associated with children's NAFLD in the allele contrast, dominant, recessive and over dominant models (G vs C,OR=3.343, 95% CI=1.524-7.334; GG+GC vs CC,OR=3.157, 95% CI=1.446-6.892;GG vs GC+CC,OR=5.692, 95% CI=1.941-16.689; GG+CC vs GC,OR=2.756, 95% CI=1.729-4.392). Four case-control studies compared Children with nonalcoholic fatty liver(NAFL) and children with nonalcoholic steatohepatitis(NASH). The results showed that the PNPLA3 gene polymorphism was also significantly associated with the severity of NAFLD in children in recessive gene model(GG vs GC+CC,OR = 14.43, 95% CI = 5.985-34.997); The Egger's test revealed no significant publication bias. Conclusions: Meta-analysis showed that PNPLA3 gene polymorphism was significantly associated with susceptibility and severity of NAFLD in children. trial registration number： CRD42019134056.

scholarly journals Circulating Irisin Levels in Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Jie Hu ◽  
Yani Ke ◽  
Fangping Wu ◽  
Shan Liu ◽  
Conghua Ji ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Disease ◽  
Subgroup Analysis ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Asian Studies ◽  
Nonalcoholic Fatty Liver ◽  
Healthy Group

Background and Aims. Previous studies have revealed the close relation of irisin with the occurrence and development of nonalcoholic fatty liver disease (NAFLD). A systematic review and meta-analysis were conducted to evaluate the association of circulating irisin levels and NAFLD. Methods. A systematic literature search of PubMed, Embase, Cochrane Library, Clinicaltrials.gov, WANFANG, CNKI, and CBM databases was performed for relevant articles till August 2020. The weighted mean difference (WMD) values and 95% confidence intervals (CIs) were estimated to compare the case-control studies and pooled results using meta-analysis. Results. The meta-analysis included 5 case-control studies with a total of 1087 people. The results revealed that the circulating irisin levels showed no significant difference between NAFLD and healthy groups ( WMD = 7.51 (-12.53, 27.56) ng/ml, P > 0.05 ). Subgroup analysis based on races showed that the average irisin levels were higher in the NAFLD group than in the healthy group ( WMD = 13.53 (0.71, 26.34) ng/ml, P < 0.05 ) in 4 Asian studies. Subgroup analysis based on disease severity from 3 Asian studies revealed that the average irisin levels were higher in the NAFLD group than in the healthy group ( WMD = 25.1 (22.85, 27.51) ng/ml, P < 0.05 and WMD = 13.52 (22.85, 27.51) ng/ml, P < 0.05 , respectively). Subgroup analysis including 3 studies from Asia suggested that the irisin levels were higher in mild NAFLD than in moderate-severe NAFLD ( WMD = 11.68 (9.03, 14.32) ng/ml, P < 0.05 ). Conclusion. The average irisin levels might be higher in the NAFLD group than in the healthy group in Asians. The irisin levels in the mild NAFLD group might be higher than those in the moderate-severe group in Asians. It is important to monitor the changing trend of irisin levels in predicting the course of NAFLD disease and its changes.

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