An Investigator-Blinded Randomized Controlled Prospective Study Comparing Efficacy, Tolerability, and Safety of Two Bowel Preparations in the Community Setting: Miralax Versus PEG Electrolyte Lavage Solution (PEG-ELS)

2015 ◽  
Vol 110 ◽  
pp. S585
Author(s):  
Sarosh Bukhari ◽  
Alan Shapiro
Keyword(s):  
Prospective Study ◽  
Community Setting ◽  
Randomized Controlled ◽  
Bowel Preparations ◽  
Lavage Solution

Decision support by telephone: Randomized controlled trial in a rural community setting

2012 ◽  
Vol 89 (1) ◽  
pp. 134-142 ◽  
Author(s):  
Jeffrey Belkora ◽  
Lauren Stupar ◽  
Sara O’Donnell ◽  
Aimee Loucks ◽  
Dan Moore ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Decision Support ◽  
Rural Community ◽  
Controlled Trial ◽  
Community Setting ◽  
Randomized Controlled

A Randomized, Prospective Study to Evaluate The Efficacy and Acceptance of Three Bowel Preparations for Colonoscopy in Children

1999 ◽  
Vol 94 (12) ◽  
pp. 3497-3501 ◽  
Author(s):  
Ahmed Dahshan ◽  
Chuan-Hao Lin ◽  
John Peters ◽  
Ronald Thomas ◽  
Vasundhara Tolia
Keyword(s):  
Prospective Study ◽  
Bowel Preparations

scholarly journals Reduced risk of venous thromboembolism with the use of intermittent pneumatic compression after craniotomy: a randomized controlled prospective study

2019 ◽  
Vol 130 (2) ◽  
pp. 622-628 ◽  
Author(s):  
Julian Prell ◽  
Grit Schenk ◽  
Bettina-Maria Taute ◽  
Christian Scheller ◽  
Christian Marquart ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Venous Thromboembolism ◽  
Prospective Study ◽  
Controlled Trial ◽  
Intermittent Pneumatic Compression ◽  
Control Group ◽  
Compression Stockings ◽  
Clinical Trial Registration ◽  
Randomized Controlled ◽  
Duration Of Surgery

OBJECTIVEThe term “venous thromboembolism” (VTE) subsumes deep venous thrombosis (DVT) and pulmonary embolism. The incidence of DVT after craniotomy was reported to be as high as 50%. Even clinically silent DVT may lead to potentially fatal pulmonary embolism. The risk of VTE is correlated with duration of surgery, and it appears likely that it develops during surgery. The present study aimed to evaluate intraoperative use of intermittent pneumatic compression (IPC) of the lower extremity for prevention of VTE in patients undergoing craniotomy.METHODSA total of 108 patients undergoing elective craniotomy for intracranial pathology were included in a single-center controlled randomized prospective study. In the control group, conventional compression stockings were worn during surgery. In the treatment group, IPC of the calves was used in addition. The presence of DVT was evaluated by Doppler sonography pre- and postoperatively.RESULTSIntraoperative use of IPC led to a significant reduction of VTE (p = 0.029). In logistic regression analysis, the risk of VTE was approximately quartered by the use of IPC. Duration of surgery was confirmed to be correlated with VTE incidence (p < 0.01); every hour of surgery increased the risk by a factor of 1.56.CONCLUSIONSIntraoperative use of IPC significantly lowers the incidence of potentially fatal VTE in patients undergoing craniotomy. The method is easy to use and carries no additional risks.■ CLASSIFICATION OF EVIDENCE Type of question: therapeutic; study design: randomized controlled trial; evidence: class I.Clinical trial registration no.: DRKS00011783 (https://www.drks.de)

scholarly journals Blockage of interleukin-1β with canakinumab in patients with Covid-19

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Lorenza Landi ◽  
Claudia Ravaglia ◽  
Emanuele Russo ◽  
Pierluigi Cataleta ◽  
Maurizio Fusari ◽  
...  
Keyword(s):  
Overall Survival ◽  
Prospective Study ◽  
Controlled Trials ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Randomized Controlled ◽  
Duration Of Hospitalization ◽  
Observational Cohort ◽  
Absolute Lymphocyte Counts ◽  
Overall Mortality

AbstractThere is the urgent need to study the effects of immunomodulating agents as therapy for Covid-19. An observational, cohort, prospective study with 30 days of observation was carried out to assess clinical outcomes in 88 patients hospitalized for Covid-19 pneumonia and treated with canakinumab (300 mg sc). Median time from diagnosis of Covid-19 by viral swab to administration of canakinumab was 7.5 days (range 0–30, IQR 4–11). Median PaO2/FiO2 increased from 160 (range 53–409, IQR 122–210) at baseline to 237 (range 72–533, IQR 158–331) at day 7 after treatment with canakinumab (p < 0.0001). Improvement of oxygen support category was observed in 61.4% of cases. Median duration of hospitalization following administration of canakinumab was 6 days (range 0–30, IQR 4–11). At 7 days, 58% of patients had been discharged and 12 (13.6%) had died. Significant differences between baseline and 7 days were observed for absolute lymphocyte counts (mean 0.60 vs 1.11 × 109/L, respectively, p < 0.0001) and C-reactive protein (mean 31.5 vs 5.8 mg/L, respectively, p < 0.0001).Overall survival at 1 month was 79.5% (95% CI 68.7–90.3). Oxygen-support requirements improved and overall mortality was 13.6%. Confirmation of the efficacy of canakinumab for Covid-19 warrants further study in randomized controlled trials.

scholarly journals Dyslipidemia in HIV-positive patients: a randomized, controlled, prospective study on ezetimibe+fenofibrate versus pravastatin monotherapy

2014 ◽  
Vol 17 (1) ◽  
pp. 19004 ◽  
Author(s):  
Anna M Grandi ◽  
Eleonora Nicolini ◽  
Laura Rizzi ◽  
Sara Caputo ◽  
Filippo Annoni ◽  
...  
Keyword(s):  
Prospective Study ◽  
Hiv Positive ◽  
Randomized Controlled

scholarly journals Efficacy of new class I medical device for actinic keratoses: a randomized controlled prospective study

2019 ◽  
pp. 1-6
Author(s):  
Federica Veronese ◽  
Elisa Zavattaro ◽  
Gionathan Orioni ◽  
Gianluca Landucci ◽  
Vanessa Tarantino ◽  
...  
Keyword(s):  
Prospective Study ◽  
Medical Device ◽  
Class I ◽  
Actinic Keratoses ◽  
New Class ◽  
Randomized Controlled

scholarly journals A Prospective Randomized Controlled Trial of AJG522 versus Standard PEG + E as Bowel Preparation for Colonoscopy

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Toshihiko Sagawa ◽  
Ken Sato ◽  
Taku Tomizawa ◽  
Masafumi Mizuide ◽  
Hidetoshi Yasuoka ◽  
...  
Keyword(s):  
Bowel Preparation ◽  
Controlled Trial ◽  
Bowel Function ◽  
Liquid Volume ◽  
Randomized Controlled ◽  
Stimulant Laxative ◽  
Bowel Cleansing ◽  
Prospective Randomized Controlled Trial ◽  
Bowel Preparations ◽  
To Receive

Polyethylene glycol- (PEG-) based bowel preparations for colonoscopies are often poorly tolerated due to the large volumes of fluid intake required. We compared low-volume “modified” PEG + ascorbic acid (AJG522) with standard PEG with electrolytes (PEG + E) in addition to a stimulant laxative and an agent to improve bowel function for the bowel cleansing before colonoscopy to evaluate its efficacy, safety, and acceptability. Outpatients scheduled to undergo colonoscopy were randomized to receive either AJG522 or PEG + E. Bowel cleansing conditions were assessed via macroscopic fecal findings by blinded and independent investigators. A survey of the patients’ feedback regarding the preparation was conducted by questionnaire. Successful cleansing was achieved in all cases, except for 4 cases in the PEG + E group, at 3 hours after taking the preparation. The fecal properties were significantly clearer in the AJG522 group than in the PEG + E group at 2 hours after taking each preparationP=0.013. Although the total liquid volume of the bowel preparation was not reduced, the AJG522 preparation could significantly reduce the required volume of the preparationP<0.0001. Moreover, the patients in the AJG522 group had better acceptabilityP=0.010. There were no significant differences in the safety profiles between groups (UMIN000013892).

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