scholarly journals S0675 Increased Risk of Ischemic Heart Disease in Inflammatory Bowel Disease Is Attenuated by Anti-TNF Therapy: A Population-Based Study

2020 ◽  
Vol 115 (1) ◽  
pp. S338-S339
Author(s):  
George Khoudari ◽  
Emad Mansoor ◽  
Ahmed Eltelbany ◽  
Mariam N. Rana ◽  
Sadeer Al-Kindi ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Bowel Disease ◽  
Population Based ◽  
Ischemic Heart ◽  
Population Based Study ◽  
Increased Risk ◽  
Inflammatory Bowel

Increased risk of ischemic heart disease and diabetes in inflammatory bowel disease

2020 ◽  
Author(s):  
Zhihui Li ◽  
Lili Qiao ◽  
Xiaojing Yun ◽  
Fangjuan Du ◽  
Shilei Xing ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Bowel Disease ◽  
Meta Analysis ◽  
Ischemic Heart ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Increased Risk ◽  
Inflammatory Bowel

Abstract Background Previous studies showed inconsistent results regarding associations between inflammatory bowel disease (IBD) and risk of ischemic heart disease (IHD) and diabetes. The present study aimed to make a meta-analysis to assess the risk of IHD and diabetes in IBD. Methods We searched for articles published before February 2020 in the databases as follows: PubMed, Web of Science, Medline, EMBASE, and Google Scholar. We computed odds ratio (OR) or relative risk (RR) and 95 % confidence intervals (CI) regarding the association between IBD and risk of IHD or diabetes by using STATA 13.0 software. Results The present meta-analysis showed that IBD was associated with higher risk of IHD (OR/RR = 1.26, 95 % CI 1.20 to 1.32, I2 = 88.3 %, p < 0.0001). Additionally, both ulcerative colitis (UC) and Crohn’s disease (CD) were associated with higher risk of IHD (UC: OR/RR = 1.19, 95 % CI 1.13 to 1.26, I2 = 65.6 %, p = 0.001; CD: OR/RR = 1.33, 95 % CI 1.17 to 1.51, I2 = 89.5 %, p < 0.0001). The study showed that IBD was associated with elevated risk of diabetes (OR/RR = 1.26, 95 % CI 1.03 to 1.53, I2 = 92.1 %, I2 = 92.1 %, p < 0.0001). Additionally, both UC and CD were associated with higher risk of diabetes (UC: OR/RR = 1.33, 95 % CI 1.03 to 1.71, I2 = 93.8 %, p < 0.0001; CD: OR/RR = 1.39, 95 % CI 1.10 to 1.76, I2 = 76.7 %, p = 0.002). Conclusion In conclusion, patients with IBD are at increased risk of IHD and diabetes. Thus, regular monitoring of biomarkers of IHD and blood glucose levels should be considered for the early detection of IHD and diabetes in IBD patients.

scholarly journals Patients with Inflammatory Bowel Disease Are at an Increased Risk of Parkinson’s Disease: A South Korean Nationwide Population-Based Study

2019 ◽  
Vol 8 (8) ◽  
pp. 1191 ◽  
Author(s):  
Seona Park ◽  
Jihye Kim ◽  
Jaeyoung Chun ◽  
Kyungdo Han ◽  
Hosim Soh ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Health Care ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Population Based ◽  
Health Care Use ◽  
Population Based Study ◽  
Increased Risk ◽  
Icd 10 ◽  
Inflammatory Bowel

Background and Aims: It is not known whether inflammatory bowel disease (IBD) enhances the risk of Parkinson’s disease (PD) or whether PD diagnosis is the result of increased health care use. We determined the risk of developing PD among patients with IBD in terms of health care and medication use. Methods: A nationwide population-based study was conducted using claims data from the Korean National Health care Insurance service. From 2010 to 2013, patients with Crohn’s disease (CD) and ulcerative colitis (UC) were identified through both International Classification of Disease, Tenth Revision (ICD-10) and national rare intractable disease (RID) registration program codes. We compared 38,861 IBD patients with age and sex-matched non-IBD individuals at a ratio of 1:3. Patients with newly diagnosed PD were identified through both ICD-10 and RID codes. Results: The incidence of PD among patients with IBD was 49 per 100,000 person-years. The risk of developing PD in patients with IBD was significantly higher than controls even after adjustment for health care use (adjusted hazard ratio (aHR), 1.87; P < 0.001). Compared to controls, the risk of PD was significantly higher in patients with CD (aHR, 2.23; P = 0.023) and UC (aHR, 1.85; P < 0.001). Corticosteroid use showed a preventive effect on developing PD in patients with CD (aHR 0.08; P < 0.001), but not UC (aHR, 0.75; P = 0.213). Among 2110 patients receiving anti-tumor necrosis factor (anti-TNF), none of the treated patients experienced PD during 9950 person-years. Conclusion: Patients with IBD are at an increased risk of PD, regardless of health care use. Corticosteroid and anti-TNF use may prevent PD in patients with IBD.

Su1840 - Increased Risk of Herpes Zoster in Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Study

2018 ◽  
Vol 154 (6) ◽  
pp. S-602-S-603
Author(s):  
Hosim Soh ◽  
Kyungdo Han ◽  
Jaeyoung Chun ◽  
Seona Park ◽  
Gukhwan Choi ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Herpes Zoster ◽  
Bowel Disease ◽  
Population Based ◽  
Population Based Study ◽  
Increased Risk ◽  
Inflammatory Bowel
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